Substituted benzoyl derivatives and herbicidal compositions

ABSTRACT

A substituted benzoyl derivative of the formula: ##STR1## ps wherein R is a lower alkyl group, or a phenyl group unsubstituted or substituted by a lower alkyl group, halogen atom or a lower alkoxy group; 
     n is an integer of 2 0r 3; 
     m is an integer of from 0 to 6, and when m is an integer of from 2 to 6, the plurality of R may be the same or different fron one another; 
     l is an integer of 0, 1 or 2; 
     X is a halogen atom, a nitro group, a cyano group, a lower alkyl group, a lower alkoxy group, or a lower haloalkyl group; 
     Y is a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group unsubstituted or substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, or a lower alkoxy carbonyl group; and 
     Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group, a lower haloalkylthio group, a lower alkylsulfinyl group, a lower haloalkylsulfinyl group, a lower alkylsulfonyl group, or a lower haloalkylsulfonyl group.

This application is a divisional of Ser. No. 460,631, filed Feb. 8, 1991.

BACKGROUND OF THE INVENTION Field of the Invention

The present invention relates to novel substituted benzoyl derivatives, processes for their production and herbicidal compositions containing them.

Discussion of Background

As a result of extensive researches over years, the present inventors have found that the compounds of the present invention have herbicidal activities remarkably high as compared with conventional herbicides, and many of the compounds of the present invention have excellent selectivity for certain crop plants, particularly for gramineous crop plants such as corn and wheat, and thus are practically useful. The present invention has been accomplished on the basis of these discoveries.

Namely, the compounds of the present invention are so effective that the dose of the active ingredient per unit area can substantially be reduced as compared with conventional herbicidal compounds, and their phytotoxicity against crop plants is extremely low as compared with conventional herbicides. Therefore, their economical effects are substantial. Further, with the compounds of the present invention, it is possible to substantially reduce a danger of environmental pollution due to application of agricultural chemicals in large amounts, and little adverse effects to other crop plants due to the effects remaining in soil are observed. Therefore, the compounds of the present invention may be regarded as epoch-making herbicides.

SUMMARY OF THE INVENTION

The present invention provides a substituted benzoyl derivative of the formula: ##STR2## wherein R is a lower alkyl group, or a phenyl group unsubstituted or substituted by a lower alkyl group, halogen atom or a lower alkoxy group;

n is an integer of 2 or 3;

m is an integer of from 0 to 6, and when m is an integer of from 2 to 6, the plurality of R may be the same or different from one another;

l is an integer of 0, 1 or 2;

X is a halogen atom, a nitro group, a cyano group, a lower alkyl group, a lower alkoxy group, or a lower haloalkyl group;

Y is a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group unsubstituted or substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, or a lower alkoxy carbonyl group; and

Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group, a lower haloalkylthio group, a lower alkylsulfinyl group, a lower haloalkylsulfinyl group, a lower alkylsulfonyl group, or a lower haloalkylsulfonyl group.

The present invention also provides a herbicidal composition comprising a herbicidally effective amount of the substituted benzoyl derivative of the formula I and an agricultural carrier or diluent.

Now, the present invention will be described in detail with reference to the preferred embodiments.

The compound of the present invention is a novel compound not disclosed in literatures and has excellent physiological activities as a herbicide.

The compound of the present invention takes the following three structures by tautomerism; ##STR3##

In the above formulas, R, n, m, l, X, Y and Z are as defined above. The compound of the formula I of the present invention can easily be produced by the following reaction. ##STR4## In the above formulas, Q¹ is --N(CH₃)₂, --N(CH₂ CH₃)₂, ##STR5## Q² is a halogen atom, and R, n, m, l, X, Y and Z are as defined above.

The compound of the formula II (l=0) can be obtained in good yield in accordance with the reaction disclosed in e.g. Synthesis, p. 368 (1978), J. Amer. Chem. Soc. Vol. 74, p. 1569 (1952). The compound of the formula III can be prepared in accordance with the methods disclosed in e.g. Journal of the Chemical Society, p. 1406 (1934), and the Journal of Organic Chemistry, Vol. 39, p 725 (1974).

The compounds of the formulas II and III are reacted in a suitable solvent, if necessary in the presence of an organic base such as pyridine or triethylamine, whereby the compound of the formula I (l=0) of the present invention can be prepared in good yield. If necessary, the compound of the formula I (l=0) of the present invention is reacted with an oxidizing agent such as m-chloroperbenzoic acid or an aqueous hydrogen peroxide solution to obtain the compound of the formula I (l=1 or 2) of the present invention. Now, the compound of the formula I of the present invention will be described in further detail with reference to Preparation Examples of some representative compounds.

PREPARATION EXAMPLE 1 ##STR6##

To a solution of 27.6 g of tetrahydrothiopyran-3-one (J. Amer. Chem. Soc. 74, 1569 (1952)) in 300 ml of benzene, 20.3 g of pyrrolidine and 0.5 g of p-toluene sulfonic acid were added, and the mixture was refluxed for five hours by means of a Dean-Stark trap. After cooling the mixture, the solvent was distilled off, and the residue was subjected to distillation under reduced pressure to obtain 36.3 g of a fraction distilled at a temperature of from 98° to 100° C. under 0.3 mmHg (yield 89%). By the ¹ H-NMR analysis, the product was ascertained to be the above identified pyrrolidine enamine.

PREPARATION EXAMPLE 2 ##STR7##

To a solution of 9 g of 4-methyl-3-oxotetrahydrothiophene (Synthesis 368 (1978)) in 80 ml of benzene, 6 g of pyrrolidine and 0.1 g of p-toluenesulfonic acid were added, and the mixture was refluxed for 3 hours by means of a Dean-Stark trap. After cooling the mixture, the solvent was distilled off and the residue was subjected to distillation under reduced pressure to obtain 9.6 g of a fraction distilled at a temperature of from 70° to 85° C. under 0.2 mmHg (yield: 74%). From the ¹ H-NMR analysis, the product was ascertained to be the above identified enamine.

PREPARATION EXAMPLE 3 Compound No. 1 of the Present Invention ##STR8##

3.8 g (22 mmol) of the enamine obtained in Preparation Example 1 was dissolved in 60 ml of methylene chloride, and 2.45 g (24 mmol) of triethylamine was added thereto. Then, 4.7 g (22 mmol) of 2,4-dichlorobenzoic acid chloride was added thereto, and the mixture was stirred at room temperature overnight. Then, 18 ml of a 2.5N hydrochloric acid aqueous solution was added thereto, and the mixture was stirred for two hours. The reaction solution was extracted with methylene chloride, washed with water and then dried under anhydrous sodium sulfate. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 3.26 g of a crystal product (melting point: 134°-135° C.). By the ¹ H-NMR and Mass analyses, the product was found to comprise two benzoyl molecules bonded to each other.

1.47 g (3.2 mmol) of the crystal product was dissolved in 10 ml of ethanol, and 10 ml of an aqueous solution having 0.27 g of sodium hydroxide dissolved therein, was added thereto. The mixture was stirred at room temperature overnight. Then, the mixture was acidified with an aqueous hydrochloric acid solution and then extracted with chloroform and dried. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 0.68 g of a brown liquid. From the ¹ H-NMR and Mass analyses, the product was ascertained to be 2-(2,4-dichlorobenzoyl)-tetrahydrothiopyran-3-one [yield: 74%, brown liquid, refractive index n_(D) 20 1.6288.

¹ H-NMR δvalue: ((CDCl₃)) 2.16((tt, J=6Hz, 6Hz, 2H) 2.60(t, J=6Hz, 2H), 2.73(t, J=6Hz, 2H), 7.13(s, 2H), 7.31(s, 1H)]

PREPARATION EXAMPLE 4 Compound No. 1736 of the Present Invention ##STR9##

2.5 g (15 mmol) of the enamine obtained in Preparation Example 2 was dissolved in 50 ml of methylene chloride, and 1.65 g (16 mmol) of triethylamine was added thereto. Then, 3.1 g (14 mmol) of 2,4-dichlorobenzoic acid chloride was added thereto, and the mixture was stirred at room temperature overnight. To the reaction solution, 20 ml of a 2.5N hydrochloric acid aqueous solution was added, and the mixture was stirred at room temperature for 4 hours. Then, the mixture was extracted with chloroform, washed with water and dried over anhydrous sodium sulfate. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 1.57 g of a crystal product. From the ¹ H-NMR and Mass analyses, the product was ascertained to be 2-(2,4-dichlorobenzoyl)-tetrahydrohydrothiophen-3-one.

[Yield: 37%, dark green crystal, melting point: 55°-58° C.,

¹ H-NMR δvalue: ((CDCl₃)) 1.26-1.37(m, 3H), 2.73-3.28(m,3H), 7.25-7.50(m, 3H), 12.5-13.5(b,1H)]

PREPARATION EXAMPLE 5 Compound No. 32 of the Present Invention ##STR10##

2.5 g (15 mmol) of the enamine obtained in Preparation Example 1 was dissolved in 60 ml of methylene chloride, and then 4.4 g (44 mmol) of triethylamine and 0.05 g of 4-dimethylaminopyridine were added thereto. The mixture was cooled with ice. The, 3.2 g (14 mmol) of 4-chloro-2-nitrobenzoic acid chloride was gradually added thereto. The mixture was stirred at room temperature overnight. To the reaction solution, 20 ml of a 2.5 N hydrochloric acid aqueous solution was added, and the mixture was stirred for further three hours. The mixture was extracted with chloroform, washed with water and dried over anhydrous sodium sulfate. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 1.38 g of a reddish brown crystal product. From the ¹ H-NMR and Mass analyses, the product was ascertained to be 2-(4-chloro-2-nitrobenzoyl)-tetrahydrothiopyran-3-one.

[Yield: 32%, reddish brown crystal,

melting point: 113°-116° C.,

¹ H-NMR δvalue: ((CDCl₃)) 2.16((tt, J=6Hz, 6Hz, 2H), 2.61(t, J=6Hz, 2H), 2.72(t, J=6Hz, 2H), 7.34(d, J=8Hz, 1H), 7.71(dd, J=2Hz, J=8Hz, 1H), 8.15(d, J=2Hz, 1H)]

PREPARATION EXAMPLE 6 Compound No. 3 of the Present Invention ##STR11##

Two g (11.8 mmol) of the enamine obtained in Preparation Example 1 and 3.6 g (3equivalent) of triethylamine were dissolved in dry methylene chloride, and while cooling the mixture in an ice bath, 2.6 (11.8 mmol) of 2-chloro-4-nitrobenzoic acid chloride was dropwise added thereto, and the mixture was stirred at room temperature overnight.

Then, 20 ml of a 2N hydrochloric acid aqueous solution was added thereto, and the mixture was stirred for 3 hours. Then, water was added thereto, and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and chloroform was distilled off under reduced pressure. The product was isolated by column chromatography to obtain 0.35 g (yield: 10%, melting point: 59.2°-62.5° C.) of desired 2-(2-chloro-4-nitrobenzoyl) tetrahydrothiopyran-3-one.

¹ H-NMR δvalue: ((CDCl₃)) 2-3.2 ppm(m, 6H), 7.1-8.5 ppm(m, 3H), 15.2 ppm(br, 1H).

MS: M⁺ =299

Melting point: 59.5°-62.5° C.]

PREPARATION EXAMPLE 7 Compound No. 2 of the Present Invention ##STR12##

1.33 g (7.9 mmol) of the enamine prepared in Preparation Example 1 and 1.2 g (11.9 mmol) of triethylamine were dissolved in 60 ml of tetrahydrofuran and cooled with ice. Then, 2 g (7.9 mmol) of 2-chloro-4-methylsulfonylbenzoic acid chloride was dissolved in 10 ml of tetrahydrofuran and gradually added to the above solution. The mixture was stirred at room temperature for one hour and then stirred at a temperature of from 60° to 70° C. for two hours. After cooling the mixture, the solvent was distilled off, and 50 ml of chloroform and 20 ml of an aqueous hydrochloric acid solution were added to the residue, and the mixture was stirred at room temperature for one hour. Then, the product was extracted with chloroform, washed with water and dried over anhydrous sodium sulfate. After filtration and removal of the solvent by distillation, the product was purified by column chromatography to obtain 0.32 g of slightly yellow crystal. From the ¹ H-NMR analysis, the product was ascertained to be 2-(2-chloro-4-methylsulfonylbenzoyl)-tetrahydrothiopyran-3-one.

[Yield: 12%, slightly yellow crystal, melting point: 111°-113° C.,

¹ H-NMR δvalue: ((CDCl₃)) 2.22(tt, J=6HZ, 2H), 2.68(t, J=6Hz, 2H), 2.79(t, J=6Hz, 2H), 3.09(s, 3H), 7.51(d, J=8Hz, 1H), 7.90(dd, J=2Hz, 8Hz, 1H), 8.00(d, J=2Hz, 1H), 15.77(b,1H)]

PREPARATION EXAMPLE 8 Compound No. 17 of the Present Invention ##STR13##

Two g (11.8 mmol) of the enamine obtained in Preparation Example 1 and 1.8 g (1.5 equivalent) of triethylamine were dissolved in 50 ml of dry tetrahydrofuran, and 2.4 g (9 mmol) of 2-chloro-3-methyl-4-methylsulfonylbenzoic acid chloride was dropwise added thereto while cooling with an ice bath, and the mixture was stirred at room temperature overnight.

Then, tetrahydrofuran was distilled off under reduced pressure, and then, 30 ml of chloroform was added thereto. Further, 20 ml of a 2N hydrochloric acid aqueous solution was added thereto, and the mixture was stirred for three hours. After an addition of water, the product was extracted with chloroform and dried over anhydrous sodium sulfate. Then, chloroform was distilled off under reduced pressure, and the product was purified by column chromatography to obtain 0.33 g (yield: 10.6%, melting point: 141.5°-144.0° C.) of 2-(2-chloro-3-methyl-4-methylsulfonylbenzoyl)-tetrahydrothiopyran-3-one.

1H-NMR δvalue; ((CDCl₃)) 1.8-3.0 ppm(m, 6H), 2.8 ppm(s, 3H), 3.1 ppm(s, 3H), 7.3 ppm(d, 2H), 8.05 ppm(d, 2H), 1.52 ppm(br, 1H)

MS: M⁺ =346, melting point: 14.5°-144.0° C.]

PREPARATION EXAMPLE 9 Compound No. 29 of the Present Invention ##STR14##

0.59 g (3.5 mmol) of the enamine obtained in Preparation Example 1 and 0.53 g (1.5 equivalent) of triethylamine were dissolved in 50 ml of dry tetrehydrofuran, and 0.93 g (3.5 mmol) of 2-methyl-3-ethoxycarbonyl- 4-methylsulfonylbenzoic acid chloride was dropwise added, while cooling the solution with an ice bath. The mixture was stirred at room temperature for two hours. The mixture was then heated to 65° C. and stirred for further two hours.

Tetrahydrofuran was distilled off under reduced pressure, and 30 ml of chloroform was added to the residue. Further, 20 ml of a 2N hydrochloric acid aqueous solution was added thereto, and the mixture was stirred for 3 hours. After an addition of water, the product was extracted with chloroform and dried over anhydrous sodium sulfate. Chloroform was distilled off under reduced pressure, and the product was purified by column chromatography to obtain 0.13 g (yield: 10%) of 2-(2-methyl-3-ethoxycarbonyl-4-methylsulfonylbenzoyl)-tetrahydrothiopyran-3-one.

^(H) -NMR δvalue: ((CDCl₃)) 1.4 ppm(t, 3H), 2.3 ppm(s, 3H), 3.2 ppm(s, 3H), 1.7-3.3 ppm(m, 6H), 4.5 ppm(q, 2H), 7.1-8.2 ppm (m, 2H), 15.5 ppm(br)]

PREPARATION EXAMPLE 10 Compound No. 30 of the Present Invention ##STR15##

0.8 g (4.7 mmol) of the enamine obtained in Preparation Example 1 and 0.93 g (2 equivalent) of triethylamine were dissolved in 50 ml of dry tetrahydrofuran. Then, 1.27 g (4.6 mmol) of 2-methyl-3-methoxymethyl-4-methylsulfonylbenzoic acid chloride was dropwise added thereto while cooling with an ice bath. The mixture was stirred at room temperature overnight. Then, tetrahydrofuran was distilled off under reduced pressure, and 30 ml of chloroform was added to the residue, and 20 ml of a 2N hydrochloric acid aqueous solution was further added thereto. The mixture was stirred for 3 hours. After an addition of water, the product was extracted with chloroform and dried over anhydrous sodium sulfate. Then, chloroform was distilled off under reduced pressure, and the product was purified by column chromatography to obtain 0.53 g (yield: 32.4%, melting point: 151.5°-154.5° C.) of 2-(2-methyl-3-methoxymethyl-4-methylsulfonylbenzoyl)tetrahydrothiopyran-3-one.

[¹ H-NMR δvalue: ((CDCl₃)) 2≧3 ppm(6H, m), 2.4 ppm(3H, s), 3.15 ppm(3H, s), 3.45 ppm(3H, s), 4.9 ppm(2H, s), 7-8 ppm (2H)

Melting point: 151.5-154.4° C.]

In a manner similar to the above reactions, compounds of the formula I of the present invention as identified in Tables 1 and 2 can be prepared. However, the present invention is not limited to such specific compounds.

The Compound Nos. in Tables 1 and 2 will be referred to in the subsequent Formulation Examples and Test Examples.

When the compound of the present invention is to be used as a herbicide, it is usually mixed with a suitable carrier, for instance, a solid carrier such as clay, talc, bentonite or diatomaceous earth, or a liquid carrier such as water, an alcohol (such as methanol or ethanol), an aromatic hydrocarbon (such as benzene, toluene or xylene), a chlorinated hydrocarbon, an ether, a ketone, an ester (such as ethyl acetate), or an acid amide (such as dimethylformamide). If desired, an emulsifier, a dispersing agent, a suspending agent, a penetrating agent, a spreader or a stabilizer may be added to prepare an optional formulation such as a liquid formulation, an emulsifiable concentrate, a wettable powder, a dust, a granule or a flowable. There is no particular restriction as to the content of the compound of the present invention as the active ingredient in such a formulation. However, the content is usually preferably within a range of from 0.10 to 90.0% by weight. Further, if desired, other herbicides, various insecticides, bacteriocides, plant growth regulating agents or synergism agents, may be combined at the time of the preparation of the formulations or at the time of the application. As such compounds to be combined, there may be mentioned, for instance, compounds disclosed in Farm Chemicals Handbook, the 75th Edition (1989).

The compound of the present invention can be applied to control various weeds not only in the agricultural and horticultural fields such as upland fields, paddy fields or orchards, but also in non-agricultural fields such as play grounds, non-used vacant fields, or rail way sides.

The dose varies depending upon the application site, the season for application, the manner of application, the type of weeds to be controlled, the type of crop plants, etc. However, the dose is usually within a range of from 0.005 to 10 kg per hectare as the amount of the active ingredient.

Now, Formulation Examples of the herbicides containing the compounds of the present invention as active ingredients, will be given. However, it should be understood that the present invention is by no means restricted to such specific Examples. In the following Formulation Examples, "parts" means "parts by weight".

Liquid Formulation

Active ingredient: 5-75 parts, preferably 10-50 parts, more preferably 15-40 parts,

Liquid carrier: 95-25 parts, preferably 88-30 parts, more preferably 82-40 parts,

Surfactant: 1∝30 parts, preferably 2-20 parts.

Emulsifiable Concentrate

Active ingredient: 1-50 parts, preferably 5-45 parts, more preferably 10-40 parts,

Surfactant: 1-30 parts, preferably 2-25 parts, more preferably 3-20 parts,

Liquid carrier: 20-95 parts, preferably 30-93 parts, more preferably 57-85 parts,

Dust

Active ingredient: 0.5-10 parts, preferably 15-40 parts,

Solid carrier: 95.9-90 parts.

Flowable

Active ingredient: 5-75 parts, preferably 10-50 parts,

Water: 94-25 parts, preferably 90-30 parts,

Surfactant: 1-30 parts, preferably 2-20 parts.

Wettable Powder

Active ingredient: 2.5-90 parts, preferably 10-80 parts, more preferably 20-75 parts,

Surfactant: 0.5-20 parts, preferably 1-15 parts, more preferably 2-10 parts,

Liquid carrier: 5-90 parts, preferably, 7.5-88 parts, more preferably 16-56 parts.

Granule

Active ingredient: 0.1-30 parts,

Solid carrier: 995.-70 parts.

The liquid formulation and the emulsifiable concentrate are prepared by dissolving the active ingredient in a liquid carrier containing a surfactant. The wettable powder is prepared by mixing a surfactant, a solid carrier and the active ingredient, followed by pulverization.

The dust is prepared by mixing a surfactant, a solid carrier and the active ingredient, if necessary, followed pulverization.

The flowable is prepared by suspending and dispersing the active ingredient in an aqueous solution containing a surfactant. The granule is prepared by mixing the active ingredient with an ajuvant.

FORMULATION EXAMPLE 1 Wettable Powder

    ______________________________________                                         Compound No. 1 of the present invention                                                                    50 parts                                           Zeeklite PFP (tradename for a kaolin-type                                                                  43 parts                                           clay, manufactured by Toho Chemical                                            Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                   5 parts                                           nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                       2 parts                                           preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder. In its use, the above wettable powder is diluted with water from 10 to 10,000 times and applied so that the active ingredient will be from 0.005 to 10 kg per hectare.

FORMULATION EXAMPLE 2 Emulsifiable Concentrate

    ______________________________________                                         Compound No. 2 of the present invention                                                                  10 parts                                             Xylene                    70 parts                                             N,N-dimethylformamide     10 parts                                             Sorpol 2680 (tradename for a mixture of a                                                                10 parts                                             nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously mixed to form an emulsifiable concentrate. In its use, the above emulsifiable concentrate is diluted with water from 10 to 10,000 times and applied so that the active ingredient will be from 0.005 to 10 kg per hectare.

FORMULATION EXAMPLE 3 Flowable

    ______________________________________                                         Compound No. 3 of the present invention                                                                   25     parts                                        Sorpol 3353 (tradename for a nonionic surfactant,                                                         10     parts                                        manufactured by Toho Chemical Co., Ltd.)                                       Runox 1000C (tradename for an anionic                                                                     0.5    part                                         surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     1% Xanthan gum aqueous solution (natural polymer)                                                         20     parts                                        Water                      44.5   parts                                        ______________________________________                                    

Sorpol 3353, Runox 1000C and the 1% Xanthan gum aqueous solution were uniformly dissolved in water, then Compound No. 3 of the present invention was added, and the mixture was thoroughly stirred. Then, the mixture was subjected to wet pulverization by a sand mil to obtain a flowable. In its use, the above flowable is diluted from 10 to 10,000 times and applied so that the active ingredient will be 0.005 to 10 kg per hectare.

FORMULATION EXAMPLE 4 Liquid Formulation

    ______________________________________                                         Compound No. 7 of the present invention                                                                  20 parts                                             Sorpol W-150 (tradename for a nonionic                                                                   10 part                                              surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Water                     70 parts                                             ______________________________________                                    

The above ingredients are uniformly mixed to form a liquid formulation. In its use, the above liquid formulation is diluted from 10 to 10,000 times and applied so that the active ingredient will be from 0.005 to 10 kg per hectare.

FORMULATION EXAMPLE 5 Liquid Formulation

    ______________________________________                                         Compound No. 17 of the present invention                                                                 30 parts                                             Nippol (tradename for a nonionic                                                                         10 parts                                             surfactant, manufactured by Nissan                                             Chemical Industries Ltd.)                                                      Water                     60 parts                                             ______________________________________                                    

The above ingredients are homogeneously mixed to obtain a liquid formulation. In its use, the above liquid formulation is diluted from 10 to 10,000 times and applied to so that the active ingredient will be from 0,005 to 10 kg per hectare.

FORMULATION EXAMPLE 6 Wettable Powder

    ______________________________________                                         Compound No. 1736 of the present invention                                                                20 parts                                            Zeeklite PFP (tradename for a kaolin-type                                                                 73 parts                                            clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                  5 parts                                            nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                      2 parts                                            preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 7 Wettable Powder

    ______________________________________                                         Compound No. 29 of the present invention                                                                  30 parts                                            Zeeklite PFP (tradename for a kaolin-type                                                                 63 parts                                            clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                  5 parts                                            nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                      2 parts                                            preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 8 Granule

    ______________________________________                                         Compound No. 32 of the present invention                                                                  5 parts                                             Bentonite                 54 parts                                             Talc                      40 parts                                             Calcium lignin sulfonate   1 part                                              ______________________________________                                    

The above ingredients were homogenously mixed and pulverized, and after an addition of a small amount of water, the mixture was stirred, mixed and granulated by an extrusion-type granulating machine, followed by drying to obtain a granule. In its use, the above granule is applied so that the active ingredient will be from 0.005 to 10 kg per hectare.

Now, the herbicidal activities of the compounds of the present invention will be described in detail with reference to the following Test Examples.

TEST EXAMPLE 1 Test on the Herbicidal Effects in Soil Treatment

A plastic box having a length of 30 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds of Echinochloa crus-galli, Digitaria adscendens, Cyperus microiria, Solanum nigrum, Galinsoga ciliata, Rorripa indica, Zea mays and Triticum aestivum were sown, and the soil was covered thereon in the thickness of about 1.5 cm, and then a herbicide solution was applied onto the surface of the soil uniformly so that the active ingredient was distributed at a predetermined concentration. The herbicide solution was prepared by diluting the liquid formulation, the wettable powder, the emulsifiable concentrate or the flowable as described in the foregoing Formulation Examples with water and applied onto the entire soil surface by means of a small spray. Three weeks after the application of the herbicidal solution, the herbicidal effects against each weed were determined on the basis of the following standard ratings.

Standard Ratings

5: Growth control rate of more than 90%

(almost completely withered)

4: Growth control rate of from 70 to 90%

3: Growth control rate of from 40 to 70%

2: Growth control rate of from 20 to 40%

1: Growth control rate of from 5 to 20%

0: Growth control rate of less than 5%

(almost non-effective)

The above growth control rates were calculated by the following equation: ##EQU1## where T: Weight of the weed growth above the soil surface of the treated area

N: Weight of the weed growth above the soil surface of the non-treated area

The results thereby obtained are shown in Table 3.

TEST EXAMPLE 2 Test 1 on the Herbicidal Effects in Foliage Treatment

A plastic box having a length of 30 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds of Echinochloa crus-galli, Digitaria adscendens, Cyperus microiria, Solanum nigrum, Galinsoga ciliata, Rorripa indica, Zea mays and Triticum aestivum were spot-wisely sown, and the soil was covered thereon in a thickness of about 1.5 cm. When the various weeds and crop plant grew to the 2 to 3 leaf stage, a herbicidal solution was uniformly sprayed on the foliages so that the active ingredient was applied in a predetermined concentration.

The herbicidal solution was prepared by diluting the liquid formulation, the wettable powder, the emulsifiable concentrate or the flowable as described in the above Formulation Examples with water and applied onto the entire surface of the foliages of the weeds and the crop plant by a small spray. Three weeks after the application of the herbicide solution, the herbicidal effects against each weed and the phytotoxicities against each crop plant were determine on the basis of the standard ratings described in Test Example 1. The results are shown in Table 4.

In the following Tables 1 and 2, Me means a methyl group, Et means an ethyl group and Ph means a phenyl group.

In Tables 3 and 4, the following abbreviations are used.

EC: Echinochloa crus-galli (barnyardgrass)

Dose: Dose of active ingredient (kg/ha)

DI: Digitaria adscendens (large crabgrass)

CY: Cyperus microiria (flatsedge)

SO: solanum nigrum (black nigthshade)

GA: Galinsoga ciliate (hairy galinsoga)

RO: Rorripa indica

ZE: Zea mays (corn)

TR: Triticum aestivum (wheat)

                                      TABLE 1                                      __________________________________________________________________________      ##STR16##                                                                     Compound No. of                       Chracteristic                            present invention                                                                       (R).sub.m                                                                              L  X   Y       Z     (Physical property)                      __________________________________________________________________________     1        --      0  Cl  H       Cl    Brown liquid                                                                   n.sub.D.sup.25 1.6288                    2        --      0  Cl  H       SO.sub.2 Me                                                                          Slightly yellow crystal                                                        m.p. 111˜113° C.            3        --      0  Cl  H       NO.sub.2                                                                             Reddish brown crystal                                                          m.p. 59.5˜62.5° C.          4        --      0  Cl  H       OMe                                            5        --      0  Cl  H       Me                                             6        --      0  Cl  H       Br                                             7        --      0  Cl  H       F     Yellowish brown                                                                liquid                                   8        --      0  Cl  H       SMe                                            9        --      0  Cl  H       S(O)Me                                         10       --      0  Cl  H       CF.sub.3                                       11       --      0  Cl  H       CN                                             12       --      0  Cl  Cl      Cl                                             13       --      0  Cl  Cl      OMe                                            14       --      0  Cl  Cl      SMe                                            15       --      0  Cl  Cl      SO.sub.2 Me                                    16       --      0  Cl  Me      Cl    Yellow liquid                                                                  n.sub.D.sup.20 1.6312                    17       --      0  Cl  Me      SO.sub.2 Me                                                                          Yellow crystal                                                                 m.p. 141.5˜144° C.          18       --      0  Cl  OMe     Cl                                             19       --      0  Cl  OMe     Br                                             20       --      0  Cl  OMe     SO.sub.2 Me                                    21       --      0  Cl  OEt     Br                                             22       --      0  Br  H       OMe                                            23       --      0  F   H       F                                              24       --      0  I   I       I                                              25       --      0  Me  H       CN                                             26       --      0  Me  H       Me                                             27       --      0  Me  H       OMe                                            28       --      0  Me  Cl      Cl                                             29       --      0  Me  CO.sub.2 Et                                                                            SO.sub.2 Me                                                                          Yellow semicrystal                       30       --      0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                                                          Slightly yellow crystal                                                        m.p. 151.5˜154.5° C.        31       --      0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    32       --      0  NO.sub.2                                                                           H       Cl    Reddish brown crystal                                                          m.p. 113˜116° C.            33       --      0  NO.sub.2                                                                           H       Br                                             34       --      0  NO.sub.2                                                                           H       F                                              35       --      0  NO.sub.2                                                                           H       CN                                             36       --      0  NO.sub.2                                                                           H       SMe                                            37       --      0  NO.sub.2                                                                           H       CF.sub.3                                                                             Slightly yellow crystal                                                        m.p. 104˜106° C.            38       --      0  NO.sub.2                                                                           OMe     Cl                                             39       --      0  NO.sub.2                                                                           OMe     CF.sub.3                                       40       --      0  CF.sub.3                                                                           H       Cl                                             41       --      0  CF.sub.3                                                                           H       Br                                             42       --      0  CF.sub.3                                                                           H       SMe                                            43       --      0  CF.sub.3                                                                           H       CF.sub.3                                       44       --      0  OMe H       Cl                                             45       --      0  OMe H       OMe   Slightly yellow crystal                                                        m.p. 101˜104° C.            46       --      1  Cl  H       Cl                                             47       --      1  Cl  H       SO.sub.2 Me                                    48       --      1  Cl  H       NO.sub.2                                       49       --      1  Cl  H       OMe                                            50       --      1  Cl  H       Me                                             51       --      1  Cl  H       Br                                             52       --      1  Cl  H       F                                              53       --      1  Cl  H       SMe                                            54       --      1  Cl  H       S(O)Me                                         55       --      1  Cl  H       CF.sub.3                                       56       --      1  Cl  H       CN                                             57       --      1  Cl  Cl      Cl                                             58       --      1  Cl  Cl      OMe                                            59       --      1  Cl  Cl      SMe                                            60       --      1  Cl  Cl      SO.sub.2 Me                                    61       --      1  Cl  Me      Cl                                             62       --      1  Cl  Me      SO.sub.2 Me                                    63       --      1  Cl  OMe     Cl                                             64       --      1  Cl  OMe     Br                                             65       --      1  Cl  OMe     SO.sub.2 Me                                    66       --      1  Cl  OEt     Br                                             67       --      1  Br  H       OMe                                            68       --      1  F   H       F                                              69       --      1  I   I       I                                              70       --      1  Me  H       CN                                             71       --      1  Me  H       Me                                             72       --      1  Me  H       OMe                                            73       --      1  Me  Cl      Cl                                             74       --      1  Me  CO.sub. 2 Me                                                                           SO.sub.2 Me                                    75       --      1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    76       --      1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    77       --      1  NO.sub.2                                                                           H       Cl                                             78       --      1  NO.sub.2                                                                           H       Br                                             79       --      1  NO.sub.2                                                                           H       F                                              80       --      1  NO.sub.2                                                                           H       CN                                             81       --      1  NO.sub.2                                                                           H       SMe                                            82       --      1  NO.sub.2                                                                           H       CF.sub.3                                       83       --      1  NO.sub.2                                                                           OMe     Cl                                             84       --      1  NO.sub.2                                                                           OMe     CF.sub.3                                       85       --      1  CF.sub.3                                                                           H       Cl                                             86       --      1  CF.sub.3                                                                           H       Br                                             87       --      1  CF.sub.3                                                                           H       SMe                                            88       --      1  CF.sub.3                                                                           H       CF.sub.3                                       89       --      1  OMe H       Cl                                             90       --      1  OMe H       OMe                                            91       --      2  Cl  H       Cl                                             92       --      2  Cl  H       SO.sub.2 Me                                    93       --      2  Cl  H       NO.sub.2                                       94       --      2  Cl  H       OMe                                            95       --      2  Cl  H       Me                                             96       --      2  Cl  H       Br                                             97       --      2  Cl  H       F                                              98       --      2  Cl  H       SMe                                            99       --      2  Cl  H       S(O)Me                                         100      --      2  Cl  H       CF.sub.3                                       101      --      2  Cl  H       CN                                             102      --      2  Cl  Cl      Cl                                             103      --      2  Cl  Cl      OMe                                            104      --      2  Cl  Cl      SMe                                            105      --      2  Cl  Cl      SO.sub.2 Me                                    106      --      2  Cl  Me      Cl                                             107      --      2  Cl  Me      SO.sub.2 Me                                    108      --      2  Cl  OMe     Cl                                             109      --      2  Cl  OMe     Br                                             110      --      2  Cl  OMe     SO.sub.2 Me                                    111      --      2  Cl  OEt     Br                                             112      --      2  Br  H       OMe                                            113      --      2  F   H       F                                              114      --      2  I   I       I                                              115      --      2  Me  H       CN                                             116      --      2  Me  H       Me                                             117      --      2  Me  H       OMe                                            118      --      2  Me  Cl      Cl                                             119      --      2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    120      --      2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    121      --      2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    122      --      2  NO.sub.2                                                                           H       Cl                                             123      --      2  NO.sub.2                                                                           H       Br                                             124      --      2  NO.sub.2                                                                           H       F                                              125      --      2  NO.sub.2                                                                           H       CN                                             126      --      2  NO.sub.2                                                                           H       SMe                                            127      --      2  NO.sub.2                                                                           H       CF.sub.3                                       128      --      2  NO.sub.2                                                                           OMe     Cl                                             129      --      2  NO.sub.2                                                                           OMe     CF.sub.3                                       130      --      2  CF.sub.3                                                                           H       Cl                                             131      --      2  CF.sub.3                                                                           H       Br                                             132      --      2  CF.sub.3                                                                           H       SMe                                            133      --      2  CF.sub.3                                                                           H       CF.sub.3                                       134      --      2  OMe H       Cl                                             135      --      2  OMe H       OMe                                            136      4-Me    0  Cl  H       Cl                                             137      4-Me    0  Cl  H       SO.sub.2 Me                                    138      4-Me    0  Cl  H       NO.sub.2                                       139      4-Me    0  Cl  H       OMe                                            140      4-Me    0  Cl  H       Me                                             141      4-Me    0  Cl  H       Br                                             142      4-Me    0  Cl  H       F                                              143      4-Me    0  Cl  H       SMe                                            144      4-Me    0  Cl  H       S(O)Me                                         145      4-Me    0  Cl  H       CF.sub.3                                       146      4-Me    0  Cl  H       CN                                             147      4-Me    0  Cl  Cl      Cl                                             148      4-Me    0  Cl  Cl      OMe                                            149      4-Me    0  Cl  Cl      SMe                                            150      4-Me    0  Cl  Cl      SO.sub.2 Me                                    151      4-Me    0  Cl  Me      Cl                                             152      4-Me    0  Cl  Me      SO.sub.2 Me                                    153      4-Me    0  Cl  OMe     Cl                                             154      4-Me    0  Cl  OMe     Br                                             155      4-Me    0  Cl  OMe     SO.sub.2 Me                                    156      4-Me    0  Cl  OEt     Br                                             157      4-Me    0  Br  H       OMe                                            158      4-Me    0  F   H       F                                              159      4-Me    0  I   I       I                                              160      4-Me    0  Me  H       CN                                             161      4-Me    0  Me  H       Me                                             162      4-Me    0  Me  H       OMe                                            163      4-Me    0  Me  Cl      Cl                                             164      4-Me    0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    165      4-Me    0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    166      4-Me    0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    167      4-Me    0  NO.sub.2                                                                           H       Cl                                             168      4-Me    0  NO.sub.2                                                                           H       Br                                             169      4-Me    0  NO.sub.2                                                                           H       F                                              170      4-Me    0  NO.sub.2                                                                           H       CN                                             171      4-Me    0  NO.sub.2                                                                           H       SMe                                            172      4-Me    0  NO.sub.2                                                                           H       CF.sub.3                                       173      4-Me    0  NO.sub.2                                                                           OMe     Cl                                             174      4-Me    0  NO.sub.2                                                                           OMe     CF.sub.3                                       175      4-Me    0  CF.sub.3                                                                           H       Cl                                             176      4-Me    0  CF.sub.3                                                                           H       Br                                             177      4-Me    0  CF.sub.3                                                                           H       SMe                                            178      4-Me    0  CF.sub.3                                                                           H       CF.sub.3                                       179      4-Me    0  OMe H       Cl                                             180      4-Me    0  OMe H       OMe                                            181      4-Me    1  Cl  H       Cl                                             182      4-Me    1  Cl  H       SO.sub.2 Me                                    183      4-Me    1  Cl  H       NO.sub.2                                       184      4-Me    1  Cl  H       OMe                                            185      4-Me    1  Cl  H       Me                                             186      4-Me    1  Cl  H       Br                                             187      4-Me    1  Cl  H       F                                              188      4-Me    1  Cl  H       SMe                                            189      4-Me    1  Cl  H       S(O)Me                                         190      4-Me    1  Cl  H       CF.sub.3                                       191      4-Me    1  Cl  H       CN                                             192      4-Me    1  Cl  Cl      Cl                                             193      4-Me    1  Cl  Cl      OMe                                            194      4-Me    1  Cl  Cl      SMe                                            195      4-Me    1  Cl  Cl      SO.sub.2 Me                                    196      4-Me    1  Cl  Me      Cl                                             197      4-Me    1  Cl  Me      SO.sub.2 Me                                    198      4-Me    1  Cl  OMe     Cl                                             199      4-Me    1  Cl  OMe     Br                                             200      4-Me    1  Cl  OMe     SO.sub.2 Me                                    201      4-Me    1  Cl  OEt     Br                                             202      4-Me    1  Br  H       OMe                                            203      4-Me    1  F   H       F                                              204      4-Me    1  I   I       I                                              205      4-Me    1  Me  H       CN                                             206      4-Me    1  Me  H       Me                                             207      4-Me    1  Me  H       OMe                                            208      4-Me    1  Me  Cl      Cl                                             209      4-Me    1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    210      4-Me    1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    211      4-Me    1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    212      4-Me    1  NO.sub.2                                                                           H       Cl                                             213      4-Me    1  NO.sub.2                                                                           H       Br                                             214      4-Me    1  NO.sub.2                                                                           H       F                                              215      4-Me    1  NO.sub.2                                                                           H       CN                                             216      4-Me    1  NO.sub.2                                                                           H       SMe                                            217      4-Me    1  NO.sub.2                                                                           H       CF.sub.3                                       218      4-Me    1  NO.sub.2                                                                           OMe     Cl                                             219      4-Me    1  NO.sub.2                                                                           OMe     CF.sub.3                                       220      4-Me    1  CF.sub.3                                                                           H       Cl                                             221      4-Me    1  CF.sub.3                                                                           H       Br                                             222      4-Me    1  CF.sub.3                                                                           H       SMe                                            223      4-Me    1  CF.sub.3                                                                           H       CF.sub.3                                       224      4-Me    1  OMe H       Cl                                             225      4-Me    1  OMe H       OMe                                            226      4-Me    2  Cl  H       Cl                                             227      4-Me    2  Cl  H       SO.sub.2 Me                                    228      4-Me    2  Cl  H       NO.sub.2                                       229      4-Me    2  Cl  H       OMe                                            230      4-Me    2  Cl  H       Me                                             231      4-Me    2  Cl  H       Br                                             232      4-Me    2  Cl  H       F                                              233      4-Me    2  Cl  H       SMe                                            234      4-Me    2  Cl  H       S(O)Me                                         235      4-Me    2  Cl  H       CF.sub.3                                       236      4-Me    2  Cl  H       CN                                             237      4-Me    2  Cl  Cl      Cl                                             238      4-Me    2  Cl  Cl      OMe                                            239      4-Me    2  Cl  Cl      SMe                                            240      4-Me    2  Cl  Cl      SO.sub.2 Me                                    241      4-Me    2  Cl  Me      Cl                                             242      4-Me    2  Cl  Me      SO.sub.2 Me                                    243      4-Me    2  Cl  OMe     Cl                                             244      4-Me    2  Cl  OMe     Br                                             245      4-Me    2  Cl  OMe     SO.sub.2 Me                                    246      4-Me    2  Cl  OEt     Br                                             247      4-Me    2  Br  H       OMe                                            248      4-Me    2  F   H       F                                              249      4-Me    I  I   I                                                      250      4-Me    2  Me  H       CN                                             251      4-Me    2  Me  H       Me                                             252      4-Me    2  Me  H       OMe                                            253      4-Me    2  Me  Cl      Cl                                             254      4-Me    2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    255      4-Me    2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    256      4-Me    2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    257      4-Me    2  NO.sub.2                                                                           H       Cl                                             258      4-Me    2  NO.sub.2                                                                           H       Br                                             259      4-Me    2  NO.sub.2                                                                           H       F                                              260      4-Me    2  NO.sub.2                                                                           H       CN                                             261      4-Me    2  NO.sub.2                                                                           H       SMe                                            262      4-Me    2  NO.sub.2                                                                           H       CF.sub.3                                       263      4-Me    2  NO.sub.2                                                                           OMe     Cl                                             264      4-Me    2  NO.sub.2                                                                           OMe     CF.sub.3                                       265      4-Me    2  CF.sub.3                                                                           H       Cl                                             266      4-Me    2  CF.sub.3                                                                           H       Br                                             267      4-Me    2  CF.sub.3                                                                           H       SMe                                            268      4-Me    2  CF.sub.3                                                                           H       CF.sub.3                                       269      4-Me    2  OMe H       Cl                                             270      4-Me    2  OMe H       OMe                                            271      5-Me    0  Cl  H       Cl                                             272      5-Me    0  Cl  H       SO.sub.2 Me                                    273      5-Me    0  Cl  H       NO.sub.2                                       274      5-Me    0  Cl  H       OMe                                            275      5-Me    0  Cl  H       Me                                             276      5-Me    0  Cl  H       Br                                             277      5-Me    0  Cl  H       F                                              278      5-Me    0  Cl  H       SMe                                            279      5-Me    0  Cl  H       S(O)Me                                         280      5-Me    0  Cl  H       CF.sub.3                                       281      5-Me    0  Cl  H       CN                                             282      5-Me    0  Cl  Cl      Cl                                             283      5-Me    0  Cl  Cl      OMe                                            284      5-Me    0  Cl  Cl      SMe                                            285      5-Me    0  Cl  Cl      SO.sub.2 Me                                    286      5-Me    0  Cl  Me      Cl                                             287      5-Me    0  Cl  Me      SO.sub.2 Me                                    288      5-Me    0  Cl  OMe     Cl                                             289      5-Me    0  Cl  OMe     Br                                             290      5-Me    0  Cl  OMe     SO.sub.2 Me                                    291      5-Me    0  Cl  OEt     Br                                             292      5-Me    0  Br  H       OMe                                            293      5-Me    0  F   H       F                                              294      5-Me    0  I   I       I                                              295      5-Me    0  Me  H       CN                                             296      5-Me    0  Me  H       Me                                             297      5-Me    0  Me  H       OMe                                            298      5-Me    0  Me  Cl      Cl                                             299      5-Me    0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    300      5-Me    0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    301      5-Me    0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    302      5-Me    0  NO.sub.2                                                                           H       Cl                                             303      5-Me    0  NO.sub.2                                                                           H       Br                                             304      5-Me    0  NO.sub.2                                                                           H       F                                              305      5-Me    0  NO.sub.2                                                                           H       CN                                             306      5-Me    0  NO.sub.2                                                                           H       SMe                                            307      5-Me    0  NO.sub.2                                                                           H       CF.sub.3                                       308      5-Me    0  NO.sub.2                                                                           OMe     Cl                                             309      5-Me    0  NO.sub.2                                                                           OMe     CF.sub.3                                       310      5-Me    O  CF.sub.3                                                                           H       Cl                                             311      5-Me    0  CF.sub.3                                                                           H       Br                                             312      5-Me    0  CF.sub.3                                                                           H       SMe                                            313      5-Me    0  CF.sub.3                                                                           H       CF.sub.3                                       314      5-Me    0  OMe H       Cl                                             315      5-Me    0  OMe H       OMe                                            316      5-Me    1  Cl  H       Cl                                             317      5-Me    1  Cl  H       SO.sub.2 Me                                    318      5-Me    1  Cl  H       NO.sub.2                                       319      5-Me    1  Cl  H       OMe                                            320      5-Me    1  Cl  H       Me                                             321      5-Me    1  Cl  H       Br                                             322      5-Me    1  Cl  H       F                                              323      5-Me    1  Cl  H       SMe                                            324      5-Me    1  Cl  H       S(O)Me                                         325      5-Me    1  Cl  H       CF.sub.3                                       326      5-Me    1  Cl  H       CN                                             327      5-Me    1  Cl  Cl      Cl                                             328      5-Me    1  Cl  Cl      OMe                                            329      5-Me    1  Cl  Cl      SMe                                            330      5-Me    1  Cl  Cl      SO.sub.2 Me                                    331      5-Me    1  Cl  Me      Cl                                             332      5-Me    1  Cl  Me      SO.sub.2 Me                                    333      5-Me    1  Cl  OMe     Cl                                             334      5-Me    1  Cl  OMe     Br                                             335      5-Me    1  Cl  OMe     SO.sub.2 Me                                    336      5-Me    1  Cl  OEt     Br                                             337      5-Me    1  Br  H       OMe                                            338      5-Me    1  F   H       F                                              339      5-Me    1  I   I       I                                              340      5-Me    1  Me  H       CN                                             341      5-Me    1  Me  H       Me                                             342      5-Me    1  Me  H       OMe                                            343      5-Me    1  Me  Cl      Cl                                             344      5-Me    1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    345      5-Me    1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    346      5-Me    1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    347      5-Me    1  NO.sub.2                                                                           H       Cl                                             348      5-Me    1  NO.sub.2                                                                           H       Br                                             349      5-Me    1  NO.sub.2                                                                           H       F                                              350      5-Me    1  NO.sub.2                                                                           H       CN                                             351      5-Me    1  NO.sub.2                                                                           H       SMe                                            352      5-Me    1  NO.sub.2                                                                           H       CF.sub.3                                       353      5-Me    1  NO.sub.2                                                                           OMe     Cl                                             354      5-Me    1  NO.sub.2                                                                           OMe     CF.sub.3                                       355      5-Me    1  CF.sub.3                                                                           H       Cl                                             356      5-Me    1  CF.sub.3                                                                           H       Br                                             357      5-Me    1  CF.sub.3                                                                           H       SMe                                            358      5-Me    1  CF.sub.3                                                                           H       CF.sub.3                                       359      5-Me    1  OMe H       Cl                                             360      5-Me    1  OMe H       OMe                                            361      5-Me    2  Cl  H       Cl                                             362      5-Me    2  Cl  H       SO.sub.2 Me                                    363      5-Me    2  Cl  H       NO.sub.2                                       364      5-Me    2  Cl  H       OMe                                            365      5-Me    2  Cl  H       Me                                             366      5-Me    2  Cl  H       Br                                             367      5-Me    2  Cl  H       F                                              368      5-Me    2  Cl  H       SMe                                            369      5-Me    2  Cl  H       S(O)Me                                         370      5-Me    2  Cl  H       CF.sub.3                                       371      5-Me    2  Cl  H       CN                                             372      5-Me    2  Cl  Cl      Cl                                             373      5-Me    2  Cl  Cl      OMe                                            374      5-Me    2  Cl  Cl      SMe                                            375      5-Me    2  Cl  Cl      SO.sub.2 Me                                    376      5-Me    2  Cl  Me      Cl                                             377      5-Me    2  Cl  Me      SO.sub.2 Me                                    378      5-Me    2  Cl  OMe     Cl                                             379      5-Me    2  Cl  OMe     Br                                             380      5-Me    2  Cl  OMe     SO.sub.2 Me                                    381      5-Me    2  Cl  OEt     Br                                             382      5-Me    2  Br  H       OMe                                            383      5-Me    2  F   H       F                                              384      5-Me    2  I   I       I                                              385      5-Me    2  Me  H       CN                                             386      5-Me    2  Me  H       Me                                             387      5-Me    2  Me  H       OMe                                            388      5-Me    2  Me  Cl      Cl                                             389      5-Me    2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    390      5-Me    2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    391      5-Me    2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    392      5-Me    2  NO.sub.2                                                                           H       Cl                                             393      5-Me    2  NO.sub.2                                                                           H       Br                                             394      5-Me    2  NO.sub.2                                                                           H       F                                              395      5-Me    2  NO.sub.2                                                                           H       CN                                             396      5-Me    2  NO.sub.2                                                                           H       SMe                                            397      5-Me    2  NO.sub.2                                                                           H       CF.sub.3                                       398      5-Me    2  NO.sub.2                                                                           OMe     Cl                                             399      5-Me    2  NO.sub.2                                                                           OMe     CF.sub.3                                       400      5-Me    2  CF.sub.3                                                                           H       Cl                                             401      5-Me    2  CF.sub.3                                                                           H       Br                                             402      5-Me    2  CF.sub.3                                                                           H       SMe                                            403      5-Me    2  CF.sub.3                                                                           H       CF.sub.3                                       404      5-Me    2  OMe H       Cl                                             405      5-Me    2  OMe H       OMe                                            406      6-Me    0  Cl  H       Cl    Slightly green liquid                                                          n.sub.D.sup.20 1.6219                    407      6-Me    0  Cl  H       SO.sub.2 Me                                    408      6-Me    0  Cl  H       NO.sub.2                                       409      6-Me    0  Cl  H       OMe                                            410      6-Me    0  Cl  H       Me                                             411      6-Me    0  Cl  H       Br                                             412      6-Me    0  Cl  H       F                                              413      6-Me    0  Cl  H       SMe                                            414      6-Me    0  Cl  H       S(O)Me                                         415      6-Me    0  Cl  H       CF.sub.3                                       416      6-Me    0  Cl  H       CN                                             417      6-Me    0  Cl  Cl      Cl                                             418      6-Me    0  Cl  Cl      OMe                                            419      6-Me    0  Cl  Cl      SMe                                            420      6-Me    0  Cl  Cl      SO.sub.2 Me                                    421      6-Me    0  Cl  Me      Cl    Slightly yellow liquid                                                         n.sub.D.sup.20 1.6203                    422      6-Me    0  Cl  Me      SO.sub.2 Me                                    423      6-Me    0  Cl  OMe     Cl                                             424      6-Me    0  Cl  OMe     Br                                             425      6-Me    0  Cl  OMe     SO.sub.2 Me                                    426      6-Me    0  Cl  OEt     Br                                             427      6-Me    0  Br  H       OMe                                            428      6-Me    0  F   H       F                                              429      6-Me    0  I   I       I                                              430      6-Me    0  Me  H       CN                                             431      6-Me    0  Me  H       Me                                             432      6-Me    0  Me  H       OMe                                            433      6-Me    0  Me  Cl      Cl                                             434      6-Me    0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    435      6-Me    0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    436      6-Me    0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    437      6-Me    0  NO.sub.2                                                                           H       Cl                                             438      6-Me    0  NO.sub.2                                                                           H       Br                                             439      6-Me    0  NO.sub.2                                                                           H       F                                              440      6-Me    0  NO.sub.2                                                                           H       CN                                             441      6-Me    0  NO.sub.2                                                                           H       SMe                                            442      6-Me    0  NO.sub.2                                                                           H       CF.sub.3                                                                             Slightly yellow crystal                                                        m.p. 88˜91° C.              443      6-Me    0  NO.sub.2                                                                           OMe     Cl                                             444      6-Me    0  NO.sub.2                                                                           OMe     CF.sub.3                                       445      6-Me    0  CF.sub.3                                                                           H       Cl                                             446      6-Me    0  CF.sub.3                                                                           H       Br                                             447      6-Me    0  CF.sub.3                                                                           H       SMe                                            448      6-Me    0  CF.sub.3                                                                           H       CF.sub.3                                       449      6-Me    0  OMe H       Cl                                             450      6-Me    0  OMe H       OMe                                            451      6-Me    1  Cl  H       Cl                                             452      6-Me    1  Cl  H       SO.sub.2 Me                                    453      6-Me    1  Cl  H       NO.sub.2                                       454      6-Me    1  Cl  H       OMe                                            455      6-Me    1  Cl  H       Me                                             456      6-Me    1  Cl  H       Br                                             457      6-Me    1  Cl  H       F                                              458      6-Me    1  Cl  H       SMe                                            459      6-Me    1  Cl  H       S(O)Me                                         460      6-Me    1  Cl  H       CF.sub.3                                       461      6-Me    1  Cl  H       CN                                             462      6-Me    1  Cl  Cl      Cl                                             463      6-Me    1  Cl  Cl      OMe                                            464      6-Me    1  Cl  Cl      SMe                                            465      6-Me    1  Cl  Cl      SO.sub.2 Me                                    466      6-Me    1  Cl  Me      Cl                                             467      6-Me    1  Cl  Me      SO.sub.2 Me                                    468      6-Me    1  Cl  OMe     Cl                                             469      6-Me    1  Cl  OMe     Br                                             470      6-Me    1  Cl  OMe     SO.sub.2 Me                                    471      6-Me    1  Cl  OEt     Br                                             472      6-Me    1  Br  H       OMe                                            473      6-Me    1  F   H       F                                              474      6-Me    1  I   I       I                                              475      6-Me    1  Me  H       CN                                             476      6-Me    1  Me  H       Me                                             477      6-Me    1  Me  H       OMe                                            478      6-Me    1  Me  Cl      Cl                                             479      6-Me    1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    480      6-Me    1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    481      6-Me    1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    482      6-Me    1  NO.sub.2                                                                           H       Cl                                             483      6-Me    1  NO.sub.2                                                                           H       Br                                             484      6-Me    1  NO.sub.2                                                                           H       F                                              485      6-Me    1  NO.sub.2                                                                           H       CN                                             486      6-Me    1  NO.sub.2                                                                           H       SMe                                            487      6-Me    1  NO.sub.2                                                                           H       CF.sub.3                                       488      6-Me    1  NO.sub.2                                                                           OMe     Cl                                             489      6-Me    1  NO.sub.2                                                                           OMe     CF.sub.3                                       490      6-Me    1  CF.sub.3                                                                           H       Cl                                             491      6-Me    1  CF.sub.3                                                                           H       Br                                             492      6-Me    1  CF.sub.3                                                                           H       SMe                                            493      6-Me    1  CF.sub.3                                                                           H       CF.sub.3                                       494      6-Me    1  OMe H       Cl                                             495      6-Me    1  OMe H       OMe                                            496      6-Me    2  Cl  H       Cl                                             497      6-Me    2  Cl  H       SO.sub.2 Me                                    498      6-Me    2  Cl  H       NO.sub.2                                       499      6-Me    2  Cl  H       OMe                                            500      6-Me    2  Cl  H       Me                                             501      6-Me    2  Cl  H       Br                                             502      6-Me    2  Cl  H       F                                              503      6-Me    2  Cl  H       SMe                                            504      6-Me    2  Cl  H       S(O)Me                                         505      6-Me    2  Cl  H       CF.sub.3                                       506      6-Me    2  Cl  H       CN                                             507      6-Me    2  Cl  Cl      Cl                                             508      6-Me    2  Cl  Cl      OMe                                            509      6-Me    2  Cl  Cl      SMe                                            510      6-Me    2  Cl  Cl      SO.sub.2 Me                                    511      6-Me    2  Cl  Me      Cl                                             512      6-Me    2  Cl  Me      SO.sub.2 Me                                    513      6-Me    2  Cl  OMe     Cl                                             514      6-Me    2  Cl  OMe     Br                                             515      6-Me    2  Cl  OMe     SO.sub.2 Me                                    516      6-Me    2  Cl  OEt     Br                                             517      6-Me    2  Br  H       OMe                                            518      6-Me    2  F   H       F                                              519      6-Me    2  I   I       I                                              520      6-Me    2  Me  H       CN                                             521      6-Me    2  Me  H       Me                                             522      6-Me    2  Me  H       OMe                                            523      6-Me    2  Me  Cl      Cl                                             524      6-Me    2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    525      6-Me    2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    526      6-Me    2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    527      6-Me    2  NO.sub.2                                                                           H       Cl                                             528      6-Me    2  NO.sub.2                                                                           H       Br                                             529      6-Me    2  NO.sub.2                                                                           H       F                                              530      6-Me    2  NO.sub. 2                                                                          H       CN                                             531      6-Me    2  NO.sub.2                                                                           H       SMe                                            532      6-Me    2  NO.sub.2                                                                           H       CF.sub.3                                       533      6-Me    2  NO.sub.2                                                                           OMe     Cl                                             534      6-Me    2  NO.sub.2                                                                           OMe     CF.sub.3                                       535      6-Me    2  CF.sub.3                                                                           H       Cl                                             536      6-Me    2  CF.sub.3                                                                           H       Br                                             537      6-Me    2  CF.sub.3                                                                           H       SMe                                            538      6-Me    2  CF.sub.3                                                                           H       CF.sub.3                                       539      6-Me    2  OMe H       Cl                                             540      6-Me    2  OMe H       OMe                                            541      4.4-diMe                                                                               0  Cl  H       Cl                                             542      4.4-diMe                                                                               0  Cl  H       SO.sub.2 Me                                    543      4.4-diMe                                                                               0  Cl  H       NO.sub.2                                       544      4.4-diMe                                                                               0  Cl  H       OMe                                            545      4.4-diMe                                                                               0  Cl  H       Me                                             546      4.4-diMe                                                                               0  Cl  H       Br                                             547      4.4-diMe                                                                               0  Cl  H       F                                              548      4.4-diMe                                                                               O  Cl  H       SMe                                            549      4.4-diMe                                                                               0  Cl  H       S(O)Me                                         550      4.4-diMe                                                                               0  Cl  H       CF.sub.3                                       551      4.4-diMe                                                                               0  Cl  H       CN                                             552      4.4-diMe                                                                               0  Cl  Cl      Cl                                             553      4.4-diMe                                                                               0  Cl  Cl      OMe                                            554      4.4-diMe                                                                               0  Cl  Cl      SMe                                            555      4.4-diMe                                                                               0  Cl  Cl      SO.sub.2 Me                                    556      4.4-diMe                                                                               0  Cl  Me      Cl                                             557      4.4-diMe                                                                               0  Cl  Me      SO.sub.2 Me                                    558      4.4-diMe                                                                               0  Cl  OMe     Cl                                             559      4.4-diMe                                                                               0  Cl  OMe     Br                                             560      4.4-diMe                                                                               0  Cl  OMe     SO.sub.2 Me                                    561      4.4-diMe                                                                               0  Cl  OEt     Br                                             562      4.4-diMe                                                                               0  Br  H       OMe                                            563      4.4-diMe                                                                               0  F   H       F                                              564      4.4-diMe                                                                               0  I   I       I                                              565      4.4-diMe                                                                               0  Me  H       CN                                             566      4.4-diMe                                                                               0  Me  H       Me                                             567      4.4-diMe                                                                               0  Me  H       OMe                                            568      4.4-diMe                                                                               0  Me  Cl      Cl                                             569      4.4-diMe                                                                               0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    570      4.4-diMe                                                                               0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    571      4.4-diMe                                                                               0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    572      4.4-diMe                                                                               0  NO.sub.2                                                                           H       Cl                                             573      4.4-diMe                                                                               0  NO.sub.2                                                                           H       Br                                             574      4.4-diMe                                                                               0  NO.sub.2                                                                           H       F                                              575      4.4-diMe                                                                               0  NO.sub.2                                                                           H       CN                                             576      4.4-diMe                                                                               0  NO.sub.2                                                                           H       SMe                                            577      4.4-diMe                                                                               0  NO.sub.2                                                                           H       CF.sub.3                                       578      4.4-diMe                                                                               0  NO.sub.2                                                                           OMe     Cl                                             579      4.4-diMe                                                                               0  NO.sub.2                                                                           OMe     CF.sub.3                                       580      4.4-diMe                                                                               0  CF.sub.3                                                                           H       Cl                                             581      4.4-diMe                                                                               0  CF.sub.3                                                                           H       Br                                             582      4.4-diMe                                                                               0  CF.sub.3                                                                           H       SMe                                            583      4.4-diMe                                                                               0  CF.sub.3                                                                           H       CF.sub.3                                       584      4.4-diMe                                                                               0  OMe H       Cl                                             585      4.4-diMe                                                                               0  OMe H       OMe                                            586      4.4-diMe                                                                               1  Cl  H       Cl                                             587      4.4-diMe                                                                               1  Cl  H       SO.sub.2 Me                                    588      4.4-diMe                                                                               1  Cl  H       NO.sub.2                                       589      4.4-diMe                                                                               1  Cl  H       OMe                                            590      4.4-diMe                                                                               1  Cl  H       Me                                             591      4.4-diMe                                                                               1  Cl  H       Br                                             592      4.4-diMe                                                                               1  Cl  H       F                                              593      4.4-diMe                                                                               1  Cl  H       SMe                                            594      4.4-diMe                                                                               1  Cl  H       S(O)Me                                         595      4.4-diMe                                                                               1  Cl  H       CF.sub.3                                       596      4.4-diMe                                                                               1  Cl  H       CN                                             597      4.4-diMe                                                                               1  Cl  Cl      Cl                                             598      4.4-diMe                                                                               1  Cl  Cl      OMe                                            599      4.4-diMe                                                                               1  Cl  Cl      SMe                                            600      4.4-diMe                                                                               1  Cl  Cl      SO.sub.2 Me                                    601      4.4-diMe                                                                               1  Cl  Me      Cl                                             602      4.4-diMe                                                                               1  Cl  Me      SO.sub.2 Me                                    603      4.4-diMe                                                                               1  Cl  OMe     Cl                                             604      4.4-diMe                                                                               1  Cl  OMe     Br                                             605      4.4-diMe                                                                               1  Cl  OMe     SO.sub.2 Me                                    606      4.4-diMe                                                                               1  Cl  OEt     Br                                             607      4.4-diMe                                                                               1  Br  H       OMe                                            608      4.4-diMe                                                                               1  F   H       F                                              609      4.4-diMe                                                                               1  I   I       I                                              610      4.4-diMe                                                                               1  Me  H       CN                                             611      4.4-diMe                                                                               1  Me  H       Me                                             612      4.4-diMe                                                                               1  Me  H       OMe                                            613      4.4-diMe                                                                               1  Me  Cl      Cl                                             614      4.4-diMe                                                                               1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    615      4.4-diMe                                                                               1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    616      4.4-diMe                                                                               1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    617      4.4-diMe                                                                               1  NO.sub.2                                                                           H       Cl                                             618      4.4-diMe                                                                               1  NO.sub.2                                                                           H       Br                                             619      4.4-diMe                                                                               1  NO.sub.2                                                                           H       F                                              620      4.4-diMe                                                                               1  NO.sub.2                                                                           H       CN                                             621      4.4-diMe                                                                               1  NO.sub.2                                                                           H       SMe                                            622      4.4-diMe                                                                               1  NO.sub.2                                                                           H       CF.sub.3                                       623      4.4-diMe                                                                               1  NO.sub.2                                                                           OMe     Cl                                             624      4.4-diMe                                                                               1  NO.sub.2                                                                           OMe     CF.sub.3                                       625      4.4-diMe                                                                               1  CF.sub.3                                                                           H       Cl                                             626      4.4-diMe                                                                               1  CF.sub.3                                                                           H       Br                                             627      4.4-diMe                                                                               1  CF.sub.3                                                                           H       SMe                                            628      4.4-diMe                                                                               1  CF.sub.3                                                                           H       CF.sub.3                                       629      4.4-diMe                                                                               1  OMe H       Cl                                             630      4.4-diMe                                                                               1  OMe H       OMe                                            631      4.4-diMe                                                                               2  Cl  H       Cl                                             632      4.4-diMe                                                                               2  Cl  H       SO.sub.2 Me                                    633      4.4-diMe                                                                               2  Cl  H       NO.sub.2                                       634      4.4-diMe                                                                               2  Cl  H       OMe                                            635      4.4-diMe                                                                               2  Cl  H       Me                                             636      4.4-diMe                                                                               2  Cl  H       Br                                             637      4.4-diMe                                                                               2  Cl  H       F                                              638      4.4-diMe                                                                               2  Cl  H       SMe                                            639      4.4-diMe                                                                               2  Cl  H       S(O)Me                                         640      4.4-diMe                                                                               2  Cl  H       CF.sub.3                                       641      4.4-diMe                                                                               2  Cl  H       CN                                             642      4.4-diMe                                                                               2  Cl  Cl      Cl                                             643      4.4-diMe                                                                               2  Cl  Cl      OMe                                            644      4.4-diMe                                                                               2  Cl  Cl      SMe                                            645      4.4-diMe                                                                               2  Cl  Cl      SO.sub.2 Me                                    646      4.4-diMe                                                                               2  Cl  Me      Cl                                             647      4.4-diMe                                                                               2  Cl  Me      SO.sub.2 Me                                    648      4.4-diMe                                                                               2  Cl  OMe     Cl                                             649      4.4-diMe                                                                               2  Cl  OMe     Br                                             650      4.4-diMe                                                                               2  Cl  OMe     SO.sub.2 Me                                    651      4.4-diMe                                                                               2  Cl  OEt     Br                                             652      4.4-diMe                                                                               2  Br  H       OMe                                            653      4.4-diMe                                                                               2  F   H       F                                              654      4.4-diMe                                                                               2  I   I       I                                              655      4.4-diMe                                                                               2  Me  H       CN                                             656      4.4-diMe                                                                               2  Me  H       Me                                             657      4.4-diMe                                                                               2  Me  H       OMe                                            658      4.4-diMe                                                                               2  Me  Cl      Cl                                             659      4.4-diMe                                                                               2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    660      4.4-diMe                                                                               2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    661      4.4-diMe                                                                               2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    662      4.4-diMe                                                                               2  NO.sub.2                                                                           H       Cl                                             663      4.4-diMe                                                                               2  NO.sub.2                                                                           H       Br                                             664      4.4-diMe                                                                               2  NO.sub.2                                                                           H       F                                              665      4.4-diMe                                                                               2  NO.sub.2                                                                           H       CN                                             666      4.4-diMe                                                                               2  NO.sub.2                                                                           H       SMe                                            667      4.4-diMe                                                                               2  NO.sub.2                                                                           H       CF.sub.3                                       668      4.4-diMe                                                                               2  NO.sub.2                                                                           OMe     Cl                                             669      4.4-diMe                                                                               2  NO.sub.2                                                                           OMe     CF.sub.3                                       670      4.4-diMe                                                                               2  CF.sub.3                                                                           H       Cl                                             671      4.4-diMe                                                                               2  CF.sub.3                                                                           H       Br                                             672      4.4-diMe                                                                               2  CF.sub.3                                                                           H       SMe                                            673      4.4-diMe                                                                               2  CF.sub.3                                                                           H       CF.sub.3                                       674      4.4-diMe                                                                               2  OMe H       Cl                                             675      4.4-diMe                                                                               2  OMe H       OMe                                            676      5.5-diMe                                                                               0  Cl  H       Cl                                             677      5.5-diMe                                                                               0  Cl  H       SO.sub.2 Me                                    678      5.5-diMe                                                                               0  Cl  H       NO.sub.2                                       679      5.5-diMe                                                                               0  Cl  H       OMe                                            680      5.5-diMe                                                                               0  Cl  H       Me                                             681      5.5-diMe                                                                               0  Cl  H       Br                                             682      5.5-diMe                                                                               0  Cl  H       F                                              683      5.5-diMe                                                                               0  Cl  H       SMe                                            684      5.5-diMe                                                                               0  Cl  H       S(O)Me                                         685      5.5-diMe                                                                               0  Cl  H       CF.sub.3                                       686      5.5-diMe                                                                               0  Cl  H       CN                                             687      5.5-diMe                                                                               0  Cl  Cl      Cl                                             688      5.5-diMe                                                                               0  Cl  Cl      OMe                                            689      5.5-diMe                                                                               0  Cl  Cl      SMe                                            690      5.5-diMe                                                                               0  Cl  Cl      SO.sub.2 Me                                    691      5.5-diMe                                                                               0  Cl  Me      Cl                                             692      5.5-diMe                                                                               0  Cl  Me      SO.sub.2 Me                                    693      5.5-diMe                                                                               0  Cl  OMe     Cl                                             694      5.5-diMe                                                                               0  Cl  OMe     Br                                             695      5.5-diMe                                                                               0  Cl  OMe     SO.sub.2 Me                                    696      5.5-diMe                                                                               0  Cl  OEt     Br                                             697      5.5-diMe                                                                               0  Br  H       OMe                                            698      5.5-diMe                                                                               0  F   H       F                                              699      5.5-diMe                                                                               0  I   I       I                                              700      5.5-diMe                                                                               0  Me  H       CN                                             701      5.5-diMe                                                                               0  Me  H       Me                                             702      5.5-diMe                                                                               0  Me  H       OMe                                            703      5.5-diMe                                                                               0  Me  Cl      Cl                                             704      5.5-diMe                                                                               0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    705      5.5-diMe                                                                               0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    706      5.5-diMe                                                                               0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    707      5.5-diMe                                                                               0  NO.sub.2                                                                           H       Cl                                             708      5.5-diMe                                                                               0  NO.sub.2                                                                           H       Br                                             709      5.5-diMe                                                                               0  NO.sub.2                                                                           H       F                                              710      5.5-diMe                                                                               0  NO.sub.2                                                                           H       CN                                             711      5.5-diMe                                                                               0  NO.sub.2                                                                           H       SMe                                            712      5.5-diMe                                                                               0  NO.sub.2                                                                           H       CF.sub.3                                       713      5.5-diMe                                                                               0  NO.sub.2                                                                           OMe     Cl                                             714      5.5-diMe                                                                               0  NO.sub.2                                                                           OMe     CF.sub.3                                       715      5.5-diMe                                                                               0  CF.sub.3                                                                           H       Cl                                             716      5.5-diMe                                                                               0  CF.sub.3                                                                           H       Br                                             717      5.5-diMe                                                                               0  CF.sub.3                                                                           H       SMe                                            718      5.5-diMe                                                                               0  CF.sub.3                                                                           H       CF.sub.3                                       719      5.5-diMe                                                                               0  OMe H       Cl                                             720      5.5-diMe                                                                               0  OMe H       OMe                                            721      5.5-diMe                                                                               1  Cl  H       Cl                                             722      5.5-diMe                                                                               1  Cl  H       SO.sub.2 Me                                    723      5.5-diMe                                                                               1  Cl  H       NO.sub.2                                       724      5.5-diMe                                                                               1  Cl  H       OMe                                            725      5.5-diMe                                                                               1  Cl  H       Me                                             726      5.5-diMe                                                                               1  Cl  H       Br                                             727      5.5-diMe                                                                               1  Cl  H       F                                              728      5.5-diMe                                                                               1  Cl  H       SMe                                            729      5.5-diMe                                                                               1  Cl  H       S(O)Me                                         730      5.5-diMe                                                                               1  Cl  H       CF.sub.3                                       731      5.5-diMe                                                                               1  Cl  H       CN                                             732      5.5-diMe                                                                               1  Cl  Cl      Cl                                             733      5.5-diMe                                                                               1  Cl  Cl      OMe                                            734      5.5-diMe                                                                               1  Cl  Cl      SMe                                            735      5.5-diMe                                                                               1  Cl  Cl      SO.sub.2 Me                                    736      5.5-diMe                                                                               1  Cl  Me      Cl                                             737      5.5-diMe                                                                               1  Cl  Me      SO.sub.2 Me                                    738      5.5-diMe                                                                               1  Cl  OMe     Cl                                             739      5.5-diMe                                                                               1  Cl  OMe     Br                                             740      5.5-diMe                                                                               1  Cl  OMe     SO.sub.2 Me                                    741      5.5-diMe                                                                               1  Cl  OEt     Br                                             742      5.5-diMe                                                                               1  Br  H       OMe                                            743      5.5-diMe                                                                               1  F   H       F                                              744      5.5-diMe                                                                               1  I   I       I                                              745      5.5-diMe                                                                               1  Me  H       CN                                             746      5.5-diMe                                                                               1  Me  H       Me                                             747      5.5-diMe                                                                               1  Me  H       OMe                                            748      5.5-diMe                                                                               1  Me  Cl      Cl                                             749      5.5-diMe                                                                               1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    750      5.5-diMe                                                                               1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    751      5.5-diMe                                                                               1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    752      5.5-diMe                                                                               1  NO.sub.2                                                                           H       Cl                                             753      5.5-diMe                                                                               1  NO.sub.2                                                                           H       Br                                             754      5.5-diMe                                                                               1  NO.sub.2                                                                           H       F                                              755      5.5-diMe                                                                               1  NO.sub.2                                                                           H       CN                                             756      5.5-diMe                                                                               1  NO.sub.2                                                                           H       SMe                                            757      5.5-diMe                                                                               1  NO.sub.2                                                                           H       CF.sub.3                                       758      5.5-diMe                                                                               1  NO.sub.2                                                                           OMe     Cl                                             759      5.5-diMe                                                                               1  NO.sub.2                                                                           OMe     CF.sub.3                                       760      5.5-diMe                                                                               1  CF.sub.3                                                                           H       Cl                                             761      5.5-diMe                                                                               1  CF.sub.3                                                                           H       Br                                             762      5.5-diMe                                                                               1  CF.sub.3                                                                           H       SMe                                            763      5.5-diMe                                                                               1  CF.sub.3                                                                           H       CF.sub.3                                       764      5.5-diMe                                                                               1  OMe H       Cl                                             765      5.5-diMe                                                                               1  OMe H       OMe                                            766      5.5-diMe                                                                               2  Cl  H       Cl                                             767      5.5-diMe                                                                               2  Cl  H       SO.sub.2 Me                                    768      5.5-diMe                                                                               2  Cl  H       NO.sub.2                                       769      5.5-diMe                                                                               2  Cl  H       OMe                                            770      5.5-diMe                                                                               2  Cl  H       Me                                             771      5.5-diMe                                                                               2  Cl  H       Br                                             772      5.5-diMe                                                                               2  Cl  H       F                                              773      5.5-diMe                                                                               2  Cl  H       SMe                                            774      5.5-diMe                                                                               2  Cl  H       S(O)Me                                         775      5.5-diMe                                                                               2  Cl  H       CF.sub.3                                       776      5.5-diMe                                                                               2  Cl  H       CN                                             777      5.5-diMe                                                                               2  Cl  Cl      Cl                                             778      5.5-diMe                                                                               2  Cl  Cl      OMe                                            779      5.5-diMe                                                                               2  Cl  Cl      SMe                                            780      5.5-diMe                                                                               2  Cl  Cl      SO.sub.2 Me                                    781      5.5-diMe                                                                               2  Cl  Me      Cl                                             782      5.5-diMe                                                                               2  Cl  Me      SO.sub.2 Me                                    783      5.5-diMe                                                                               2  Cl  OMe     Cl                                             784      5.5-diMe                                                                               2  Cl  OMe     Br                                             785      5.5-diMe                                                                               2  Cl  OMe     SO.sub.2 Me                                    786      5.5-diMe                                                                               2  Cl  OEt     Br                                             787      5.5-diMe                                                                               2  Br  H       OMe                                            788      5.5-diMe                                                                               2  F   H       F                                              789      5.5-diMe                                                                               2  I   I       I                                              790      5.5-diMe                                                                               2  Me  H       CN                                             791      5.5-diMe                                                                               2  Me  H       Me                                             792      5.5-diMe                                                                               2  Me  H       OMe                                            793      5.5-diMe                                                                               2  Me  Cl      Cl                                             794      5.5-diMe                                                                               2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    795      5.5-diMe                                                                               2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    796      5.5-diMe                                                                               2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    797      5.5-diMe                                                                               2  NO.sub.2                                                                           H       Cl                                             798      5.5-diMe                                                                               2  NO.sub.2                                                                           H       Br                                             799      5.5-diMe                                                                               2  NO.sub.2                                                                           H       F                                              800      5.5-diMe                                                                               2  NO.sub.2                                                                           H       CN                                             801      5.5-diMe                                                                               2  NO.sub.2                                                                           H       SMe                                            802      5.5-diMe                                                                               2  NO.sub.2                                                                           H       CF.sub.3                                       803      5.5-diMe                                                                               2  NO.sub.2                                                                           OMe     Cl                                             804      5.5-diMe                                                                               2  NO.sub.2                                                                           OMe     CF.sub.3                                       805      5.5-diMe                                                                               2  CF.sub.3                                                                           H       Cl                                             806      5.5-diMe                                                                               2  CF.sub.3                                                                           H       Br                                             807      5.5-diMe                                                                               2  CF.sub.3                                                                           H       SMe                                            808      5.5-diMe                                                                               2  CF.sub.3                                                                           H       CF.sub.3                                       809      5.5-diMe                                                                               2  OMe H       Cl                                             810      5.5-diMe                                                                               2  OMe H       OMe                                            811      6.6-diMe                                                                               0  Cl  H       Cl                                             812      6.6-diMe                                                                               0  Cl  H       SO.sub.2 Me                                    813      6.6-diMe                                                                               0  Cl  H       NO.sub.2                                       814      6.6-diMe                                                                               0  Cl  H       OMe                                            815      6.6-diMe                                                                               0  Cl  H       Me                                             816      6.6-diMe                                                                               0  Cl  H       Br                                             817      6.6-diMe                                                                               0  Cl  H       F                                              818      6.6-diMe                                                                               0  Cl  H       SMe                                            819      6.6-diMe                                                                               0  Cl  H       S(O)Me                                         820      6.6-diMe                                                                               0  Cl  H       CF.sub.3                                       821      6.6-diMe                                                                               0  Cl  H       CN                                             822      6.6-diMe                                                                               0  Cl  Cl      Cl                                             823      6.6-diMe                                                                               0  Cl  Cl      OMe                                            824      6.6-diMe                                                                               0  Cl  Cl      SMe                                            825      6.6-diMe                                                                               0  Cl  Cl      SO.sub.2 Me                                    826      6.6-diMe                                                                               0  Cl  Me      Cl                                             827      6.6-diMe                                                                               0  Cl  Me      SO.sub.2 Me                                    828      6.6-diMe                                                                               0  Cl  OMe     Cl                                             829      6.6-diMe                                                                               0  Cl  OMe     Br                                             830      6.6-diMe                                                                               0  Cl  OMe     SO.sub.2 Me                                    831      6.6-diMe                                                                               0  Cl  OEt     Br                                             832      6.6-diMe                                                                               0  Br  H       OMe                                            833      6.6-diMe                                                                               0  F   H       F                                              834      6.6-diMe                                                                               0  I   I       I                                              835      6.6-diMe                                                                               0  Me  H       CN                                             836      6.6-diMe                                                                               0  Me  H       Me                                             837      6.6-diMe                                                                               0  Me  H       OMe                                            838      6.6-diMe                                                                               0  Me  Cl      Cl                                             839      6.6-diMe                                                                               0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    840      6.6-diMe                                                                               0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    841      6.6-diMe                                                                               0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    842      6.6-diMe                                                                               0  NO.sub.2                                                                           H       Cl                                             843      6.6-diMe                                                                               0  NO.sub.2                                                                           H       Br                                             844      6.6-diMe                                                                               0  NO.sub.2                                                                           H       F                                              845      6.6-diMe                                                                               0  NO.sub.2                                                                           H       CN                                             846      6.6-diMe                                                                               0  NO.sub.2                                                                           H       SMe                                            847      6.6-diMe                                                                               0  NO.sub.2                                                                           H       CF.sub.3                                       848      6.6-diMe                                                                               0  NO.sub.2                                                                           OMe     Cl                                             849      6.6-diMe                                                                               0  NO.sub.2                                                                           OMe     CF.sub.3                                       850      6.6-diMe                                                                               0  CF.sub.3                                                                           H       Cl                                             851      6.6-diMe                                                                               0  CF.sub.3                                                                           H       Br                                             852      6.6-diMe                                                                               0  CF.sub.3                                                                           H       SMe                                            853      6.6-diMe                                                                               0  CF.sub.3                                                                           H       CF.sub.3                                       854      6.6-diMe                                                                               0  OMe H       Cl                                             855      6.6-diMe                                                                               0  OMe H       OMe                                            856      6.6-diMe                                                                               1  Cl  H       Cl                                             857      6.6-diMe                                                                               1  Cl  H       SO.sub.2 Me                                    858      6.6-diMe                                                                               1  Cl  H       NO.sub.2                                       859      6.6-diMe                                                                               1  Cl  H       OMe                                            860      6.6-diMe                                                                               1  Cl  H       Me                                             861      6.6-diMe                                                                               1  Cl  H       Br                                             862      6.6-diMe                                                                               1  Cl  H       F                                              863      6.6-diMe                                                                               1  Cl  H       SMe                                            864      6.6-diMe                                                                               1  Cl  H       S(O)Me                                         865      6.6-diMe                                                                               1  Cl  H       CF.sub.3                                       866      6.6-diMe                                                                               1  Cl  H       CN                                             867      6.6-diMe                                                                               1  Cl  Cl      Cl                                             868      6.6-diMe                                                                               1  Cl  Cl      OMe                                            869      6.6-diMe                                                                               1  Cl  Cl      SMe                                            870      6.6-diMe                                                                               1  Cl  Cl      SO.sub.2 Me                                    871      6.6-diMe                                                                               1  Cl  Me      Cl                                             872      6.6-diMe                                                                               1  Cl  Me      SO.sub.2 Me                                    873      6.6-diMe                                                                               1  Cl  OMe     Cl                                             874      6.6-diMe                                                                               1  Cl  OMe     Br                                             875      6.6-diMe                                                                               1  Cl  OMe     SO.sub.2 Me                                    876      6.6-diMe                                                                               1  Cl  OEt     Br                                             877      6.6-diMe                                                                               1  Br  H       OMe                                            878      6.6-diMe                                                                               1  F   H       F                                              879      6.6-diMe                                                                               1  I   I       I                                              880      6.6-diMe                                                                               1  Me  H       CN                                             881      6.6-diMe                                                                               1  Me  H       Me                                             882      6.6-diMe                                                                               1  Me  H       OMe                                            883      6.6-diMe                                                                               1  Me  Cl      Cl                                             884      6.6-diMe                                                                               1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    885      6.6-diMe                                                                               1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    886      6.6-diMe                                                                               1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    887      6.6-diMe                                                                               1  NO.sub.2                                                                           H       Cl                                             888      6.6-diMe                                                                               1  NO.sub.2                                                                           H       Br                                             889      6.6-diMe                                                                               1  NO.sub.2                                                                           H       F                                              890      6.6-diMe                                                                               1  NO.sub.2                                                                           H       CN                                             891      6.6-diMe                                                                               1  NO.sub.2                                                                           H       SMe                                            892      6.6-diMe                                                                               1  NO.sub.2                                                                           H       CF.sub.3                                       893      6.6-diMe                                                                               1  NO.sub.2                                                                           OMe     Cl                                             894      6.6-diMe                                                                               1  NO.sub.2                                                                           OMe     CF.sub.3                                       895      6.6-diMe                                                                               1  CF.sub.3                                                                           H       Cl                                             896      6.6-diMe                                                                               1  CF.sub.3                                                                           H       Br                                             897      6.6-diMe                                                                               1  CF.sub.3                                                                           H       SMe                                            898      6.6-diMe                                                                               1  CF.sub.3                                                                           H       CF.sub.3                                       899      6.6-diMe                                                                               1  OMe H       Cl                                             900      6.6-diMe                                                                               1  OMe H       OMe                                            901      6.6-diMe                                                                               2  Cl  H       Cl                                             902      6.6-diMe                                                                               2  Cl  H       SO.sub.2 Me                                    903      6.6-diMe                                                                               2  Cl  H       NO.sub.2                                       904      6.6-diMe                                                                               2  Cl  H       OMe                                            905      6.6-diMe                                                                               2  Cl  H       Me                                             906      6.6-diMe                                                                               2  Cl  H       Br                                             907      6.6-diMe                                                                               2  Cl  H       F                                              908      6.6-diMe                                                                               2  Cl  H       SMe                                            909      6.6-diMe                                                                               2  Cl  H       S(O)Me                                         910      6.6-diMe                                                                               2  Cl  H       CF.sub.3                                       911      6.6-diMe                                                                               2  Cl  H       CN                                             912      6.6-diMe                                                                               2  Cl  Cl      Cl                                             913      6.6-diMe                                                                               2  Cl  Cl      OMe                                            914      6.6-diMe                                                                               2  Cl  Cl      SMe                                            915      6.6-diMe                                                                               2  Cl  Cl      SO.sub.2 Me                                    916      6.6-diMe                                                                               2  Cl  Me      Cl                                             917      6.6-diMe                                                                               2  Cl  Me      SO.sub.2 Me                                    918      6.6-diMe                                                                               2  Cl  OMe     Cl                                             919      6.6-diMe                                                                               2  Cl  OMe     Br                                             920      6.6-diMe                                                                               2  Cl  OMe     SO.sub.2 Me                                    921      6.6-diMe                                                                               2  Cl  OEt     Br                                             922      6.6-diMe                                                                               2  Br  H       OMe                                            923      6.6-diMe                                                                               2  F   H       F                                              924      6.6-diMe                                                                               2  I   I       I                                              925      6.6-diMe                                                                               2  Me  H       CN                                             926      6.6-diMe                                                                               2  Me  H       Me                                             927      6.6-diMe                                                                               2  Me  H       OMe                                            928      6.6-diMe                                                                               2  Me  Cl      Cl                                             929      6.6-diMe                                                                               2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    930      6.6-diMe                                                                               2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    931      6.6-diMe                                                                               2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    932      6.6-diMe                                                                               2  NO.sub.2                                                                           H       Cl                                             933      6.6-diMe                                                                               2  NO.sub.2                                                                           H       Br                                             934      6.6-diMe                                                                               2  NO.sub.2                                                                           H       F                                              935      6.6-diMe                                                                               2  NO.sub.2                                                                           H       CN                                             936      6.6-diMe                                                                               2  NO.sub.2                                                                           H       SMe                                            937      6.6-diMe                                                                               2  NO.sub.2                                                                           H       CF.sub.3                                       938      6.6-diMe                                                                               2  NO.sub.2                                                                           OMe     Cl                                             939      6.6-diMe                                                                               2  NO.sub.2                                                                           OMe     CF.sub.3                                       940      6.6-diMe                                                                               2  CF.sub.3                                                                           H       Cl                                             941      6.6-diMe                                                                               2  CF.sub.3                                                                           H       Br                                             942      6.6-diMe                                                                               2  CF.sub.3                                                                           H       SMe                                            943      6.6-diMe                                                                               2  CF.sub.3                                                                           H       CF.sub.3                                       944      6.6-diMe                                                                               2  OMe H       Cl                                             945      6.6-diMe                                                                               2  OMe H       OMe                                            946      4-Ph    0  Cl  H       Cl                                             947      4-Ph    0  Cl  H       SO.sub.2 Me                                    948      4-Ph    0  Cl  H       NO.sub.2                                       949      4-Ph    0  Cl  H       OMe                                            950      4-Ph    0  Cl  H       Me                                             951      4-Ph    0  Cl  H       Br                                             952      4-Ph    0  Cl  H       F                                              953      4-Ph    0  Cl  H       SMe                                            954      4-Ph    0  Cl  H       S(O)Me                                         955      4-Ph    0  Cl  H       CF.sub.3                                       956      4-Ph    0  Cl  H       CN                                             957      4-Ph    0  Cl  Cl      Cl                                             958      4-Ph    0  Cl  Cl      OMe                                            959      4-Ph    0  Cl  Cl      SMe                                            960      4-Ph    0  Cl  Cl      SO.sub.2 Me                                    961      4-Ph    0  Cl  Me      Cl                                             962      4-Ph    0  Cl  Me      SO.sub.2 Me                                    963      4-Ph    0  Cl  OMe     Cl                                             964      4-Ph    0  Cl  OMe     Br                                             965      4-Ph    0  Cl  OMe     SO.sub.2 Me                                    966      4-Ph    0  Cl  OEt     Br                                             967      4-Ph    0  Br  H       OMe                                            968      4-Ph    0  F   H       F                                              969      4-Ph    0  I   I       I                                              970      4-Ph    0  Me  H       CN                                             971      4-Ph    0  Me  H       Me                                             972      4-Ph    0  Me  H       OMe                                            973      4-Ph    0  Me  Cl      Cl                                             974      4-Ph    0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    975      4-Ph    0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    976      4-Ph    0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    977      4-Ph    0  NO.sub.2                                                                           H       Cl                                             978      4-Ph    0  NO.sub.2                                                                           H       Br                                             979      4-Ph    0  NO.sub.2                                                                           H       F                                              980      4-Ph    0  NO.sub.2                                                                           H       CN                                             981      4-Ph    0  NO.sub.2                                                                           H       SMe                                            982      4-Ph    0  NO.sub.2                                                                           H       CF.sub.3                                       983      4-Ph    0  NO.sub.2                                                                           OMe     Cl                                             984      4-Ph    0  NO.sub.2                                                                           OMe     CF.sub.3                                       985      4-Ph    0  CF.sub.3                                                                           H       Cl                                             986      4-Ph    0  CF.sub.3                                                                           H       Br                                             987      4-Ph    0  CF.sub.3                                                                           H       SMe                                            988      4-Ph    0  CF.sub.3                                                                           H       CF.sub.3                                       989      4-Ph    0  OMe H       Cl                                             990      4-Ph    0  OMe H       OMe                                            991      4-Ph    1  Cl  H       Cl                                             992      4-Ph    1  Cl  H       SO.sub.2 Me                                    993      4-Ph    1  Cl  H       NO.sub.2                                       994      4-Ph    1  Cl  H       OMe                                            995      4-Ph    1  Cl  H       Me                                             996      4-Ph    1  Cl  H       Br                                             997      4-Ph    1  Cl  H       F                                              998      4-Ph    1  Cl  H       SMe                                            999      4-Ph    1  Cl  H       S(O)Me                                         1000     4-Ph    1  Cl  H       CF.sub.3                                       1001     4-Ph    1  Cl  H       CN                                             1002     4-Ph    1  Cl  Cl      Cl                                             1003     4-Ph    1  Cl  Cl      OMe                                            1004     4-Ph    1  Cl  Cl      SMe                                            1005     4-Ph    1  Cl  Cl      SO.sub.2 Me                                    1006     4-Ph    1  Cl  Me      Cl                                             1007     4-Ph    1  Cl  Me      SO.sub.2 Me                                    1008     4-Ph    1  Cl  OMe     Cl                                             1009     4-Ph    1  Cl  OMe     Br                                             1010     4-Ph    1  Cl  OMe     SO.sub.2 Me                                    1011     4-Ph    1  Cl  OEt     Br                                             1012     4-Ph    1  Br  H       OMe                                            1013     4-Ph    1  F   H       F                                              1014     4-Ph    1  I   I       I                                              1015     4-Ph    1  Me  H       CN                                             1016     4-Ph    1  Me  H       Me                                             1017     4-Ph    1  Me  H       OMe                                            1018     4-Ph    1  Me  Cl      Cl                                             1019     4-Ph    1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1020     4-Ph    1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1021     4-Ph    1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1022     4-Ph    1  NO.sub.2                                                                           H       Cl                                             1023     4-Ph    1  NO.sub.2                                                                           H       Br                                             1024     4-Ph    1  NO.sub.2                                                                           H       F                                              1025     4-Ph    1  NO.sub.2                                                                           H       CN                                             1026     4-Ph    1  NO.sub.2                                                                           H       SMe                                            1027     4-Ph    1  NO.sub.2                                                                           H       CF.sub.3                                       1028     4-Ph    1  NO.sub.2                                                                           OMe     Cl                                             1029     4-Ph    1  NO.sub.2                                                                           OMe     CF.sub.3                                       1030     4-Ph    1  CF.sub.3                                                                           H       Cl                                             1031     4-Ph    1  CF.sub.3                                                                           H       Br                                             1032     4-Ph    1  CF.sub.3                                                                           H       SMe                                            1033     4-Ph    1  CF.sub.3                                                                           H       CF.sub.3                                       1034     4-Ph    1  OMe H       Cl                                             1035     4-Ph    1  OMe H       OMe                                            1036     4-Ph    2  Cl  H       Cl                                             1037     4-Ph    2  Cl  H       SO.sub.2 Me                                    1038     4-Ph    2  Cl  H       NO.sub.2                                       1039     4-Ph    2  Cl  H       OMe                                            1040     4-Ph    2  Cl  H       Me                                             1041     4-Ph    2  Cl  H       Br                                             1042     4-Ph    2  Cl  H       F                                              1043     4-Ph    2  Cl  H       SMe                                            1044     4-Ph    2  Cl  H       S(O)Me                                         1045     4-Ph    2  Cl  H       CF.sub.3                                       1046     4-Ph    2  Cl  H       CN                                             1047     4-Ph    2  Cl  Cl      Cl                                             1048     4-Ph    2  Cl  Cl      OMe                                            1049     4-Ph    2  Cl  Cl      SMe                                            1050     4-Ph    2  Cl  Cl      SO.sub.2 Me                                    1051     4-Ph    2  Cl  Me      Cl                                             1052     4-Ph    2  Cl  Me      SO.sub.2 Me                                    1053     4-Ph    2  Cl  OMe     Cl                                             1054     4-Ph    2  Cl  OMe     Br                                             1055     4-Ph    2  Cl  OMe     SO.sub.2 Me                                    1056     4-Ph    2  Cl  OEt     Br                                             1057     4-Ph    2  Br  H       OMe                                            1058     4-Ph    2  F   H       F                                              1059     4-Ph    2  I   I       I                                              1060     4-Ph    2  Me  H       CN                                             1061     4-Ph    2  Me  H       Me                                             1062     4-Ph    2  Me  H       OMe                                            1063     4-Ph    2  Me  Cl      Cl                                             1064     4-Ph    2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1065     4-Ph    2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1066     4-Ph    2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1067     4-Ph    2  NO.sub.2                                                                           H       Cl                                             1068     4-Ph    2  NO.sub.2                                                                           H       Br                                             1069     4-Ph    2  NO.sub.2                                                                           H       F                                              1070     4-Ph    2  NO.sub.2                                                                           H       CN                                             1071     4-Ph    2  NO.sub.2                                                                           H       SMe                                            1072     4-Ph    2  NO.sub.2                                                                           H       CF.sub.3                                       1073     4-Ph    2  NO.sub.2                                                                           OMe     Cl                                             1074     4-Ph    2  NO.sub.2                                                                           OMe     CF.sub.3                                       1075     4-Ph    2  CF.sub.3                                                                           H       Cl                                             1076     4-Ph    2  CF.sub.3                                                                           H       Br                                             1077     4-Ph    2  CF.sub.3                                                                           H       SMe                                            1078     4-Ph    2  CF.sub.3                                                                           H       CF.sub.3                                       1079     4-Ph    2  OMe H       Cl                                             1080     4-Ph    2  OMe H       OMe                                            1081     5-Ph    0  Cl  H       Cl                                             1082     5-Ph    0  Cl  H       SO.sub.2 Me                                    1083     5-Ph    0  Cl  H       NO.sub.2                                       1084     5-Ph    0  Cl  H       OMe                                            1085     5-Ph    0  Cl  H       Me                                             1086     5-Ph    0  Cl  H       Br                                             1087     5-Ph    0  Cl  H       F                                              1088     5-Ph    0  Cl  H       SMe                                            1089     5-Ph    0  Cl  H       S(O)Me                                         1090     5-Ph    0  Cl  H       CF.sub.3                                       1091     5-Ph    0  Cl  H       CN                                             1092     5-Ph    0  Cl  Cl      Cl                                             1093     5-Ph    0  Cl  Cl      OMe                                            1094     5-Ph    0  Cl  Cl      SMe                                            1095     5-Ph    0  Cl  Cl      SO.sub.2 Me                                    1096     5-Ph    0  Cl  Me      Cl                                             1097     5-Ph    0  Cl  Me      SO.sub.2 Me                                    1098     5-Ph    0  Cl  OMe     Cl                                             1099     5-Ph    0  Cl  OMe     Br                                             1100     5-Ph    0  Cl  OMe     SO.sub.2 Me                                    1101     5-Ph    0  Cl  OEt     Br                                             1102     5-Ph    0  Br  H       OMe                                            1103     5-Ph    0  F   H       F                                              1104     5-Ph    0  I   I       I                                              1105     5-Ph    0  Me  H       CN                                             1106     5-Ph    0  Me  H       Me                                             1107     5-Ph    0  Me  H       OMe                                            1108     5-Ph    0  Me  Cl      Cl                                             1109     5-Ph    0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1110     5-Ph    0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1111     5-Ph    0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1112     5-Ph    0  NO.sub.2                                                                           H       Cl                                             1113     5-Ph    0  NO.sub.2                                                                           H       Br                                             1114     5-Ph    0  NO.sub.2                                                                           H       F                                              1115     5-Ph    0  NO.sub.2                                                                           H       CN                                             1116     5-Ph    0  NO.sub.2                                                                           H       SMe                                            1117     5-Ph    0  NO.sub.2                                                                           H       CF.sub.3                                       1118     5-Ph    0  NO.sub.2                                                                           OMe     Cl                                             1119     5-Ph    0  NO.sub.2                                                                           OMe     CF.sub.3                                       1120     5-Ph    0  CF.sub.3                                                                           H       Cl                                             1121     5-Ph    0  CF.sub.3                                                                           H       Br                                             1122     5-Ph    0  CF.sub.3                                                                           H       SMe                                            1123     5-Ph    0  CF.sub.3                                                                           H       CF.sub.3                                       1124     5-Ph    0  OMe H       Cl                                             1125     5-Ph    0  OMe H       OMe                                            1126     5-Ph    1  Cl  H       Cl                                             1127     5-Ph    1  Cl  H       SO.sub.2 Me                                    1128     5-Ph    1  Cl  H       NO.sub.2                                       1129     5-Ph    1  Cl  H       OMe                                            1130     5-Ph    1  Cl  H       Me                                             1131     5-Ph    1  Cl  H       Br                                             1132     5-Ph    1  Cl  H       F                                              1133     5-Ph    1  Cl  H       SMe                                            1134     5-Ph    1  Cl  H       S(O)Me                                         1135     5-Ph    1  Cl  H       CF.sub.3                                       1136     5-Ph    1  Cl  H       CN                                             1137     5-Ph    1  Cl  Cl      Cl                                             1138     5-Ph    1  Cl  Cl      OMe                                            1139     5-Ph    1  Cl  Cl      SMe                                            1140     5-Ph    1  Cl  Cl      SO.sub.2 Me                                    1141     5-Ph    1  Cl  Me      Cl                                             1142     5-Ph    1  Cl  Me      SO.sub.2 Me                                    1143     5-Ph    1  Cl  OMe     Cl                                             1144     5-Ph    1  Cl  OMe     Br                                             1145     5-Ph    1  Cl  OMe     SO.sub.2 Me                                    1146     5-Ph    1  Cl  OEt     Br                                             1147     5-Ph    1  Br  H       OMe                                            1148     5-Ph    1  F   H       F                                              1149     5-Ph    1  I   I       I                                              1150     5-Ph    1  Me  H       CN                                             1151     5-Ph    1  Me  H       Me                                             1152     5-Ph    1  Me  H       OMe                                            1153     5-Ph    1  Me  Cl      Cl                                             1154     5-Ph    1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1155     5-Ph    1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1156     5-Ph    1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1157     5-Ph    1  NO.sub.2                                                                           H       Cl                                             1158     5-Ph    1  NO.sub.2                                                                           H       Br                                             1159     5-Ph    1  NO.sub.2                                                                           H       F                                              1160     5-Ph    1  NO.sub.2                                                                           H       CN                                             1161     5-Ph    1  NO.sub.2                                                                           H       SMe                                            1162     5-Ph    1  NO.sub.2                                                                           H       CF.sub.3                                       1163     5-Ph    1  NO.sub.2                                                                           OMe     Cl                                             1164     5-Ph    1  NO.sub.2                                                                           OMe     CF.sub.3                                       1165     5-Ph    1  CF.sub.3                                                                           H       Cl                                             1166     5-Ph    1  CF.sub.3                                                                           H       Br                                             1167     5-Ph    1  CF.sub.3                                                                           H       SMe                                            1168     5-Ph    1  CF.sub.3                                                                           H       CF.sub.3                                       1169     5-Ph    1  OMe H       Cl                                             1170     5-Ph    1  OMe H       OMe                                            1171     5-Ph    2  Cl  H       Cl                                             1172     5-Ph    2  Cl  H       SO.sub.2 Me                                    1173     5-Ph    2  Cl  H       NO.sub.2                                       1174     5-Ph    2  Cl  H       OMe                                            1175     5-Ph    2  Cl  H       Me                                             1176     5-Ph    2  Cl  H       Br                                             1177     5-Ph    2  Cl  H       F                                              1178     5-Ph    2  Cl  H       SMe                                            1179     5-Ph    2  Cl  H       S(O)Me                                         1180     5-Ph    2  Cl  H       CF.sub.3                                       1181     5-Ph    2  Cl  H       CN                                             1182     5-Ph    2  Cl  Cl      Cl                                             1183     5-Ph    2  Cl  Cl      OMe                                            1184     5-Ph    2  Cl  Cl      SMe                                            1185     5-Ph    2  Cl  Cl      SO.sub.2 Me                                    1186     5-Ph    2  Cl  Me      Cl                                             1187     5-Ph    2  Cl  Me      SO.sub.2 Me                                    1188     5-Ph    2  Cl  OMe     Cl                                             1189     5-Ph    2  Cl  OMe     Br                                             1190     5-Ph    2  Cl  OMe     SO.sub.2 Me                                    1191     5-Ph    2  Cl  OEt     Br                                             1192     5-Ph    2  Br  H       OMe                                            1193     5-Ph    2  F   H       F                                              1194     5-Ph    2  I   I       I                                              1195     5-Ph    2  Me  H       CN                                             1196     5-Ph    2  Me  H       Me                                             1197     5-Ph    2  Me  H       OMe                                            1198     5-Ph    2  Me  Cl      Cl                                             1199     5-Ph    2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1200     5-Ph    2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1201     5-Ph    2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1202     5-Ph    2  NO.sub.2                                                                           H       Cl                                             1203     5-Ph    2  NO.sub.2                                                                           H       Br                                             1204     5-Ph    2  NO.sub.2                                                                           H       F                                              1205     5-Ph    2  NO.sub.2                                                                           H       CN                                             1206     5-Ph    2  NO.sub.2                                                                           H       SMe                                            1207     5-Ph    2  NO.sub.2                                                                           H       CF.sub.3                                       1208     5-Ph    2  NO.sub.2                                                                           OMe     Cl                                             1209     5-Ph    2  NO.sub.2                                                                           OMe     CF.sub.3                                       1210     5-Ph    2  CF.sub.3                                                                           H       Cl                                             1211     5-Ph    2  CF.sub.3                                                                           H       Br                                             1212     5-Ph    2  CF.sub.3                                                                           H       SMe                                            1213     5-Ph    2  CF.sub.3                                                                           H       CF.sub.3                                       1214     5-Ph    2  OMe H       Cl                                             1215     5-Ph    2  OMe H       OMe                                            1216     6-Ph    0  Cl  H       Cl                                             1217     6-Ph    0  Cl  H       SO.sub.2 Me                                    1218     6-Ph    0  Cl  H       NO.sub.2                                       1219     6-Ph    0  Cl  H       OMe                                            1220     6-Ph    0  Cl  H       Me                                             1221     6-Ph    0  Cl  H       Br                                             1222     6-Ph    0  Cl  H       F                                              1223     6-Ph    0  Cl  H       SMe                                            1224     6-Ph    0  Cl  H       S(O)Me                                         1225     6-Ph    0  Cl  H       CF.sub.3                                       1226     6-Ph    0  Cl  H       CN                                             1227     6-Ph    0  Cl  Cl      Cl                                             1228     6-Ph    0  Cl  Cl      OMe                                            1229     6-Ph    0  Cl  Cl      SMe                                            1230     6-Ph    0  Cl  Cl      SO.sub.2 Me                                    1231     6-Ph    0  Cl  Me      Cl                                             1232     6-Ph    0  Cl  Me      SO.sub.2 Me                                    1233     6-Ph    0  Cl  OMe     Cl                                             1234     6-Ph    0  Cl  OMe     Br                                             1235     6-Ph    0  Cl  OMe     SO.sub.2 Me                                    1236     6-Ph    0  Cl  OEt     Br                                             1237     6-Ph    0  Br  H       OMe                                            1238     6-Ph    0  F   H       F                                              1239     6-Ph    0  I   I       I                                              1240     6-Ph    0  Me  H       CN                                             1241     6-Ph    0  Me  H       Me                                             1242     6-Ph    0  Me  H       OMe                                            1243     6-Ph    0  Me  Cl      Cl                                             1244     6-Ph    0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1245     6-Ph    0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1246     6-Ph    0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1247     6-Ph    0  NO.sub.2                                                                           H       Cl                                             1248     6-Ph    0  NO.sub.2                                                                           H       Br                                             1249     6-Ph    0  NO.sub.2                                                                           H       F                                              1250     6-Ph    0  NO.sub.2                                                                           H       CN                                             1251     6-Ph    0  NO.sub.2                                                                           H       SMe                                            1252     6-Ph    0  NO.sub.2                                                                           H       CF.sub.3                                       1253     6-Ph    0  NO.sub.2                                                                           OMe     Cl                                             1254     6-Ph    0  NO.sub.2                                                                           OMe     CF.sub.3                                       1255     6-Ph    0  CF.sub.3                                                                           H       Cl                                             1256     6-Ph    0  CF.sub.3                                                                           H       Br                                             1257     6-Ph    0  CF.sub.3                                                                           H       SMe                                            1258     6-Ph    0  CF.sub.3                                                                           H       CF.sub.3                                       1259     6-Ph    0  OMe H       Cl                                             1260     6-Ph    0  OMe H       OMe                                            1261     6-Ph    1  Cl  H       Cl                                             1262     6-Ph    1  Cl  H       SO.sub.2 Me                                    1263     6-Ph    1  Cl  H       NO.sub.2                                       1264     6-Ph    1  Cl  H       OMe                                            1265     6-Ph    1  Cl  H       Me                                             1266     6-Ph    1  Cl  H       Br                                             1267     6-Ph    1  Cl  H       F                                              1268     6-Ph    1  Cl  H       SMe                                            1269     6-Ph    1  Cl  H       S(O)Me                                         1270     6-Ph    1  Cl  H       CF.sub.3                                       1271     6-Ph    1  Cl  H       CN                                             1272     6-Ph    1  Cl  Cl      Cl                                             1273     6-Ph    1  Cl  Cl      OMe                                            1274     6-Ph    1  Cl  Cl      SMe                                            1275     6-Ph    1  Cl  Cl      SO.sub.2 Me                                    1276     6-Ph    1  Cl  Me      Cl                                             1277     6-Ph    1  Cl  Me      SO.sub.2 Me                                    1278     6-Ph    1  Cl  OMe     Cl                                             1279     6-Ph    1  Cl  OMe     Br                                             1280     6-Ph    1  Cl  OMe     SO.sub.2 Me                                    1281     6-Ph    1  Cl  OEt     Br                                             1282     6-Ph    1  Br  H       OMe                                            1283     6-Ph    1  F   H       F                                              1284     6-Ph    1  I   I       I                                              1285     6-Ph    1  Me  H       CN                                             1286     6-Ph    1  Me  H       Me                                             1287     6-Ph    1  Me  H       OMe                                            1288     6-Ph    1  Me  Cl      Cl                                             1289     6-Ph    1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1290     6-Ph    1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1291     6-Ph    1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1292     6-Ph    1  NO.sub.2                                                                           H       Cl                                             1293     6-Ph    1  NO.sub.2                                                                           H       Br                                             1294     6-Ph    1  NO.sub.2                                                                           H       F                                              1295     6-Ph    1  NO.sub.2                                                                           H       CN                                             1296     6-Ph    1  NO.sub.2                                                                           H       SMe                                            1297     6-Ph    1  NO.sub.2                                                                           H       CF.sub.3                                       1298     6-Ph    1  NO.sub.2                                                                           OMe     Cl                                             1299     6-Ph    1  NO.sub.2                                                                           OMe     CF.sub.3                                       1300     6-Ph    1  CF.sub.3                                                                           H       Cl                                             1301     6-Ph    1  CF.sub.3                                                                           H       Br                                             1302     6-Ph    1  CF.sub.3                                                                           H       SMe                                            1303     6-Ph    1  CF.sub.3                                                                           H       CF.sub.3                                       1304     6-Ph    1  OMe H       Cl                                             1305     6-Ph    1  OMe H       OMe                                            1306     6-Ph    2  Cl  H       Cl                                             1307     6-Ph    2  Cl  H       SO.sub.2 Me                                    1308     6-Ph    2  Cl  H       NO.sub.2                                       1309     6-Ph    2  Cl  H       OMe                                            1310     6-Ph    2  Cl  H       Me                                             1311     6-Ph    2  Cl  H       Br                                             1312     6-Ph    2  Cl  H       F                                              1313     6-Ph    2  Cl  H       SMe                                            1314     6-Ph    2  Cl  H       S(O)Me                                         1315     6-Ph    2  Cl  H       CF.sub.3                                       1316     6-Ph    2  Cl  H       CN                                             1317     6-Ph    2  Cl  Cl      Cl                                             1318     6-Ph    2  Cl  Cl      OMe                                            1319     6-Ph    2  Cl  Cl      SMe                                            1320     6-Ph    2  Cl  Cl      SO.sub.2 Me                                    1321     6-Ph    2  Cl  Me      Cl                                             1322     6-Ph    2  Cl  Me      SO.sub.2 Me                                    1323     6-Ph    2  Cl  OMe     Cl                                             1324     6-Ph    2  Cl  OMe     Br                                             1325     6-Ph    2  Cl  OMe     SO.sub.2 Me                                    1326     6-Ph    2  Cl  OEt     Br                                             1327     6-Ph    2  Br  H       OMe                                            1328     6-Ph    2  F   H       F                                              1329     6-Ph    2  I   I       I                                              1330     6-Ph    2  Me  H       CN                                             1331     6-Ph    2  Me  H       Me                                             1332     6-Ph    2  Me  H       OMe                                            1333     6-Ph    2  Me  Cl      Cl                                             1334     6-Ph    2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1335     6-Ph    2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1336     6-Ph    2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1337     6-Ph    2  NO.sub.2                                                                           H       Cl                                             1338     6-Ph    2  NO.sub.2                                                                           H       Br                                             1339     6-Ph    2  NO.sub.2                                                                           H       F                                              1340     6-Ph    2  NO.sub.2                                                                           H       CN                                             1341     6-Ph    2  NO.sub.2                                                                           H       SMe                                            1342     6-Ph    2  NO.sub.2                                                                           H       CF.sub.3                                       1343     6-Ph    2  NO.sub.2                                                                           OMe     Cl                                             1344     6-Ph    2  NO.sub.2                                                                           OMe     CF.sub.3                                       1345     6-Ph    2  CF.sub.3                                                                           H       Cl                                             1346     6-Ph    2  CF.sub.3                                                                           H       Br                                             1347     6-Ph    2  CF.sub.3                                                                           H       SMe                                            1348     6-Ph    2  CF.sub.3                                                                           H       CF.sub.3                                       1349     6-Ph    2  OMe H       Cl                                             1350     6-Ph    2  OMe H       OMe                                            1351     5-(4-ClPh)                                                                             0  Cl  H       Cl                                             1352     5-(4-ClPh)                                                                             0  Cl  H       SO.sub.2 Me                                    1353     5-(4-ClPh)                                                                             0  Cl  H       NO.sub.2                                       1354     5-(4-ClPh)                                                                             0  Cl  H       OMe                                            1355     5-(4-ClPh)                                                                             0  Cl  H       Me                                             1356     5-(4-ClPh)                                                                             0  Cl  H       Br                                             1357     5-(4-ClPh)                                                                             0  Cl  H       F                                              1358     5-(4-ClPh)                                                                             0  Cl  H       SMe                                            1359     5-(4-ClPh)                                                                             0  Cl  H       S(O)Me                                         1360     5-(4-ClPh)                                                                             0  Cl  H       CF.sub.3                                       1361     5-(4-ClPh)                                                                             0  Cl  H       CN                                             1362     5-(4-ClPh)                                                                             0  Cl  Cl      Cl                                             1363     5-(4-ClPh)                                                                             0  Cl  Cl      OMe                                            1364     5-(4-ClPh)                                                                             0  Cl  Cl      SMe                                            1365     5-(4-ClPh)                                                                             0  Cl  Cl      SO.sub.2 Me                                    1366     5-(4-ClPh)                                                                             1  Cl  Me      Cl                                             1367     5-(4-ClPh)                                                                             1  Cl  Me      SO.sub.2 Me                                    1368     5-(4-ClPh)                                                                             1  Cl  OMe     Cl                                             1369     5-(4-ClPh)                                                                             1  Cl  OMe     Br                                             1370     5-(4-ClPh)                                                                             0  Cl  OMe     SO.sub.2 Me                                    1371     5-(4-ClPh)                                                                             0  Cl  OEt     Br                                             1372     5-(4-ClPh)                                                                             0  Br  H       OMe                                            1373     5-(4-ClPh)                                                                             0  F   H       F                                              1374     5-(4-ClPh)                                                                             0  I   I       I                                              1375     5-(4-ClPh)                                                                             0  Me  H       CN                                             1376     5-(4-ClPh)                                                                             0  Me  H       Me                                             1377     5-(4-ClPh)                                                                             0  Me  H       OMe                                            1378     5-(4-ClPh)                                                                             0  Me  Cl      Cl                                             1379     5-(4-ClPh)                                                                             0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1380     5-(4-ClPh)                                                                             0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1381     5-(4-ClPh)                                                                             0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1382     5-(4-ClPh)                                                                             0  NO.sub.2                                                                           H       Cl                                             1383     5-(4-ClPh)                                                                             0  NO.sub.2                                                                           H       Br                                             1384     5-(4-ClPh)                                                                             0  NO.sub.2                                                                           H       F                                              1385     5-(4-ClPh)                                                                             0  NO.sub.2                                                                           H       CN                                             1386     5-(4-ClPh)                                                                             0  NO.sub.2                                                                           H       SMe                                            1387     5-(4-ClPh)                                                                             0  NO.sub.2                                                                           H       CF.sub.3                                       1388     5-(4-ClPh)                                                                             0  NO.sub.2                                                                           OMe     Cl                                             1389     5-(4-ClPh)                                                                             0  NO.sub.2                                                                           OMe     CF.sub.3                                       1390     5-(4-ClPh)                                                                             0  CF.sub.3                                                                           H       Cl                                             1391     5-(4-ClPh)                                                                             0  CF.sub.3                                                                           H       Br                                             1392     5-(4-ClPh)                                                                             0  CF.sub.3                                                                           H       SMe                                            1393     5-(4-ClPh)                                                                             0  CF.sub.3                                                                           H       CF.sub.3                                       1394     5-(4-ClPh)                                                                             0  OMe H       Cl                                             1395     5-(4-ClPh)                                                                             0  OMe H       OMe                                            1396     5-(4-ClPh)                                                                             1  Cl  H       Cl                                             1397     5-(4-ClPh)                                                                             1  Cl  H       SO.sub.2 Me                                    1398     5-(4-ClPh)                                                                             1  Cl  H       NO.sub.2                                       1399     5-(4-ClPh)                                                                             1  Cl  H       OMe                                            1400     5-(4-ClPh)                                                                             1  Cl  H       Me                                             1401     5-(4-ClPh)                                                                             1  Cl  H       Br                                             1402     5-(4-ClPh)                                                                             1  Cl  H       F                                              1403     5-(4-ClPh)                                                                             1  Cl  H       SMe                                            1404     5-(4-ClPh)                                                                             1  Cl  H       S(O)Me                                         1405     5-(4-ClPh)                                                                             1  Cl  H       CF.sub.3                                       1406     5-(4-ClPh)                                                                             1  Cl  H       CN                                             1407     5-(4-ClPh)                                                                             1  Cl  Cl      Cl                                             1408     5-(4-ClPh)                                                                             1  Cl  Cl      OMe                                            1409     5-(4-ClPh)                                                                             1  Cl  Cl      SMe                                            1410     5-(4-ClPh)                                                                             1  Cl  Cl      SO.sub.2 Me                                    1411     5-(4-ClPh)                                                                             1  Cl  Me      Cl                                             1412     5-(4-ClPh)                                                                             1  Cl  Me      SO.sub.2 Me                                    1413     5-(4-ClPh)                                                                             1  Cl  OMe     Cl                                             1414     5-(4-ClPh)                                                                             1  Cl  OMe     Br                                             1415     5-(4-ClPh)                                                                             1  Cl  OMe     SO.sub.2 Me                                    1416     5-(4-ClPh)                                                                             1  Cl  OEt     Br                                             1417     5-(4-ClPh)                                                                             1  Br  H       OMe                                            1418     5-(4-ClPh)                                                                             1  F   H       F                                              1419     5-(4-ClPh)                                                                             1  I   I       I                                              1420     5-(4-ClPh)                                                                             1  Me  H       CN                                             1421     5-(4-ClPh)                                                                             1  Me  H       Me                                             1422     5-(4-ClPh)                                                                             1  Me  H       OMe                                            1423     5-(4-ClPh)                                                                             1  Me  Cl      Cl                                             1424     5-(4-ClPh)                                                                             1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1425     5-(4-ClPh)                                                                             1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1426     5-(4-ClPh)                                                                             1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1427     5-(4-ClPh)                                                                             1  NO.sub.2                                                                           H       Cl                                             1428     5-(4-ClPh)                                                                             1  NO.sub.2                                                                           H       Br                                             1429     5-(4-ClPh)                                                                             1  NO.sub.2                                                                           H       F                                              1430     5-(4-ClPh)                                                                             1  NO.sub.2                                                                           H       CN                                             1431     5-(4-ClPh)                                                                             1  NO.sub.2                                                                           H       SMe                                            1432     5-(4-ClPh)                                                                             1  NO.sub.2                                                                           H       CF.sub.3                                       1433     5-(4-ClPh)                                                                             1  NO.sub.2                                                                           OMe     Cl                                             1434     5-(4-ClPh)                                                                             1  NO.sub.2                                                                           OMe     CF.sub.3                                       1435     5-(4-ClPh)                                                                             1  CF.sub.3                                                                           H       Cl                                             1436     5-(4-ClPh)                                                                             1  CF.sub.3                                                                           H       Br                                             1437     5-(4-ClPh)                                                                             1  CF.sub.3                                                                           H       SMe                                            1438     5-(4-ClPh)                                                                             1  CF.sub.3                                                                           H       CF.sub.3                                       1439     5-(4-ClPh)                                                                             1  OMe H       Cl                                             1440     5-(4-ClPh)                                                                             1  OMe H       OMe                                            1441     5-(4-ClPh)                                                                             2  Cl  H       Cl                                             1442     5-(4-ClPh)                                                                             2  Cl  H       SO.sub.2 Me                                    1443     5-(4-ClPh)                                                                             2  Cl  H       NO.sub.2                                       1444     5-(4-ClPh)                                                                             2  Cl  H       OMe                                            1445     5-(4-ClPh)                                                                             2  Cl  H       Me                                             1446     5-(4-ClPh)                                                                             2  Cl  H       Br                                             1447     5-(4-ClPh)                                                                             2  Cl  H       F                                              1448     5-(4-ClPh)                                                                             2  Cl  H       SMe                                            1449     5-(4-ClPh)                                                                             2  Cl  H       S(O)Me                                         1450     5-(4-ClPh)                                                                             2  Cl  H       CF.sub.3                                       1451     5-(4-ClPh)                                                                             2  Cl  H       CN                                             1452     5-(4-ClPh)                                                                             2  Cl  Cl      Cl                                             1453     5-(4-ClPh)                                                                             2  Cl  Cl      OMe                                            1454     5-(4-ClPh)                                                                             2  Cl  Cl      SMe                                            1455     5-(4-ClPh)                                                                             2  Cl  Cl      SO.sub.2 Me                                    1456     5-(4-ClPh)                                                                             2  Cl  Me      Cl                                             1457     5-(4-ClPh)                                                                             2  Cl  Me      SO.sub.2 Me                                    1458     5-(4-ClPh)                                                                             2  Cl  OMe     Cl                                             1459     5-(4-Cl Ph)                                                                            2  Cl  OMe     Br                                             1460     5-(4-ClPh)                                                                             2  Cl  OMe     SO.sub.2 Me                                    1461     5-(4-ClPh)                                                                             2  Cl  OEt     Br                                             1462     5-(4-ClPh)                                                                             2  Br  H       OMe                                            1463     5-(4-ClPh)                                                                             2  F   H       F                                              1464     5-(4-ClPh)                                                                             2  I   I       I                                              1465     5-(4-ClPh)                                                                             2  Me  H       CN                                             1466     5-(4-ClPh)                                                                             2  Me  H       Me                                             1467     5-(4-ClPh)                                                                             2  Me  H       OMe                                            1468     5-(4-ClPh)                                                                             2  Me  Cl      Cl                                             1469     5-(4-ClPh)                                                                             2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1470     5-(4-ClPh)                                                                             2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1471     5-(4-ClPh)                                                                             2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1472     5-(4-ClPh)                                                                             2  NO.sub.2                                                                           H       Cl                                             1473     5-(4-ClPh)                                                                             2  NO.sub.2                                                                           H       Br                                             1474     5-(4-ClPh)                                                                             2  NO.sub.2                                                                           H       F                                              1475     5-(4-ClPh)                                                                             2  NO.sub.2                                                                           H       CN                                             1476     5-(4-ClPh)                                                                             2  NO.sub.2                                                                           H       SMe                                            1477     5-(4-ClPh)                                                                             2  NO.sub.2                                                                           H       CF.sub.3                                       1478     5-(4-ClPh)                                                                             2  NO.sub.2                                                                           OMe     Cl                                             1479     5-(4-ClPh)                                                                             2  NO.sub.2                                                                           OMe     CF.sub.3                                       1480     5-(4-ClPh)                                                                             2  CF.sub.3                                                                           H       Cl                                             1481     5-(4-ClPh)                                                                             2  CF.sub.3                                                                           H       Br                                             1482     5-(4-ClPh)                                                                             2  CF.sub.3                                                                           H       SMe                                            1483     5-(4-ClPh)                                                                             2  CF.sub.3                                                                           H       CF.sub.3                                       1484     5-(4-ClPh)                                                                             2  OMe H       Cl                                             1485     5-(4-ClPh)                                                                             2  OMe H       OMe                                            1486     5-(4-MePh)                                                                             0  Cl  H       Cl                                             1487     5-(4-MePh)                                                                             0  Cl  H       SO.sub.2 Me                                    1488     5-(4-MePh)                                                                             0  Cl  H       NO.sub.2                                       1489     5-(4-MePh)                                                                             0  Cl  H       OMe                                            1490     5-(4-MePh)                                                                             0  Cl  H       Me                                             1491     5-(4-MePh)                                                                             0  Cl  H       Br                                             1492     5-(4-MePh)                                                                             0  Cl  H       F                                              1493     5-(4-MePh)                                                                             0  Cl  H       SMe                                            1494     5-(4-MePh)                                                                             0  Cl  H       S(O)Me                                         1495     5-(4-MePh)                                                                             0  Cl  H       CF.sub.3                                       1496     5-(4-MePh)                                                                             0  Cl  H       CN                                             1497     5-(4-MePh)                                                                             0  Cl  Cl      Cl                                             1498     5-(4-MePh)                                                                             0  Cl  Cl      OMe                                            1499     5-(4-MePh)                                                                             0  Cl  Cl      SMe                                            1500     5-(4-MePh)                                                                             0  Cl  Cl      SO.sub.2 Me                                    1501     5-(4-MePh)                                                                             0  Cl  Me      Cl                                             1502     5-(4-MePh)                                                                             0  Cl  Me      SO.sub.2 Me                                    1503     5-(4-MePh)                                                                             0  Cl  OMe     Cl                                             1504     5-(4-MePh)                                                                             0  Cl  OMe     Br                                             1505     5-(4-MePh)                                                                             0  Cl  OMe     SO.sub.2 Me                                    1506     5-(4-MePh)                                                                             0  Cl  OEt     Br                                             1507     5-(4-MePh)                                                                             0  Br  H       OMe                                            1508     5-(4-MePh)                                                                             0  F   H       F                                              1509     5-(4-MePh)                                                                             0  I   I       I                                              1510     5-(4-MePh)                                                                             0  Me  H       CN                                             1511     5-(4-MePh)                                                                             0  Me  H       Me                                             1512     5-(4-MePh)                                                                             0  Me  H       OMe                                            1513     5-(4-MePh)                                                                             0  Me  Cl      Cl                                             1514     5-(4-MePh)                                                                             0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1515     5-(4-MePh)                                                                             0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1516     5-(4-MePh)                                                                             0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1517     5-(4-MePh)                                                                             0  NO.sub.2                                                                           H       Cl                                             1518     5-(4-MePh)                                                                             0  NO.sub.2                                                                           H       Br                                             1519     5-(4-MePh)                                                                             0  NO.sub.2                                                                           H       F                                              1520     5-(4-MePh)                                                                             0  NO.sub.2                                                                           H       CN                                             1521     5-(4-MePh)                                                                             0  NO.sub.2                                                                           H       SMe                                            1522     5-(4-MePh)                                                                             0  NO.sub.2                                                                           H       CF.sub.3                                       1523     5-(4-MePh)                                                                             0  NO.sub.2                                                                           OMe     Cl                                             1524     5-(4-MePh)                                                                             0  NO.sub.2                                                                           OMe     CF.sub.3                                       1525     5-(4-MePh)                                                                             0  CF.sub.3                                                                           H       Cl                                             1526     5-(4-MePh)                                                                             0  CF.sub.3                                                                           H       Br                                             1527     5-(4-MePh)                                                                             0  CF.sub.3                                                                           H       SMe                                            1528     5-(4-MePh)                                                                             0  CF.sub.3                                                                           H       CF.sub.3                                       1529     5-(4-MePh)                                                                             0  OMe H       Cl                                             1530     5-(4-MePh)                                                                             0  OMe H       OMe                                            1531     5-(4-MePh)                                                                             1  Cl  H       Cl                                             1532     5-(4-MePh)                                                                             1  Cl  H       SO.sub.2 Me                                    1533     5-(4-MePh)                                                                             1  Cl  H       NO.sub.2                                       1534     5-(4-MePh)                                                                             1  Cl  H       OMe                                            1535     5-(4-MePh)                                                                             1  Cl  H       Me                                             1536     5-(4-MePh)                                                                             1  Cl  H       Br                                             1537     5-(4-MePh)                                                                             1  Cl  H       F                                              1538     5-(4-MePh)                                                                             1  Cl  H       SMe                                            1539     5-(4-MePh)                                                                             1  Cl  H       S(O)Me                                         1540     5-(4-MePh)                                                                             1  Cl  H       CF.sub.3                                       1541     5-(4-MePh)                                                                             1  Cl  H       CN                                             1542     5-(4-MePh)                                                                             1  Cl  Cl      Cl                                             1543     5-(4-MePh)                                                                             1  Cl  Cl      OMe                                            1544     5-(4-MePh)                                                                             1  Cl  Cl      SMe                                            1545     5-(4-MePh)                                                                             1  Cl  Cl      SO.sub.2 Me                                    1546     5-(4-MePh)                                                                             1  Cl  Me      Cl                                             1547     5-(4-MePh)                                                                             1  Cl  Me      SO.sub.2 Me                                    1548     5-(4-MePh)                                                                             1  Cl  OMe     Cl                                             1549     5-(4-MePh)                                                                             1  Cl  OMe     Br                                             1550     5-(4-MePh)                                                                             1  Cl  OMe     SO.sub.2 Me                                    1551     5-(4-MePh)                                                                             1  Cl  OEt     Br                                             1552     5-(4-MePh)                                                                             1  Br  H       OMe                                            1553     5-(4-MePh)                                                                             1  F   H       F                                              1554     5-(4-MePh)                                                                             1  I   I       I                                              1555     5-(4-MePh)                                                                             1  Me  H       CN                                             1556     5-(4-MePh)                                                                             1  Me  H       Me                                             1557     5-(4-MePh)                                                                             1  Me  H       OMe                                            1558     5-(4-MePh)                                                                             1  Me  Cl      Cl                                             1559     5-(4-MePh)                                                                             1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1560     5-(4-MePh)                                                                             1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1561     5-(4-MePh)                                                                             1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1562     5-(4-MePh)                                                                             1  NO.sub.2                                                                           H       Cl                                             1563     5-(4-MePh)                                                                             1  NO.sub.2                                                                           H       Br                                             1564     5-(4-MePh)                                                                             1  NO.sub.2                                                                           H       F                                              1565     5-(4-MePh)                                                                             1  NO.sub.2                                                                           H       CN                                             1566     5-(4-MePh)                                                                             1  NO.sub.2                                                                           H       SMe                                            1567     5-(4-MePh)                                                                             1  NO.sub.2                                                                           H       CF.sub.3                                       1568     5-(4-MePh)                                                                             1  NO.sub.2                                                                           OMe     Cl                                             1569     5-(4-MePh)                                                                             1  NO.sub.2                                                                           OMe     CF.sub.3                                       1570     5-(4-MePh)                                                                             1  CF.sub.3                                                                           H       Cl                                             1571     5-(4-MePh)                                                                             1  CF.sub.3                                                                           H       Br                                             1572     5-(4-MePh)                                                                             1  CF.sub.3                                                                           H       SMe                                            1573     5-(4-MePh)                                                                             1  CF.sub.3                                                                           H       CF.sub.3                                       1574     5-(4-MePh)                                                                             1  OMe H       Cl                                             1575     5-(4-MePh)                                                                             1  OMe H       OMe                                            1576     5-(4-MePh)                                                                             2  Cl  H       Cl                                             1577     5-(4-MePh)                                                                             2  Cl  H       SO.sub.2 Me                                    1578     5-(4-MePh)                                                                             2  Cl  H       NO.sub.2                                       1579     5-(4-MePh)                                                                             2  Cl  H       OMe                                            1580     5-(4-MePh)                                                                             2  Cl  H       Me                                             1581     5-(4-MePh)                                                                             2  Cl  H       Br                                             1582     5-(4-MePh)                                                                             2  Cl  H       F                                              1583     5-(4-MePh)                                                                             2  Cl  H       SMe                                            1584     5-(4-MePh)                                                                             2  Cl  H       S(O)Me                                         1585     5-(4-MePh)                                                                             2  Cl  H       CF.sub.3                                       1586     5-(4-MePh)                                                                             2  Cl  H       CN                                             1587     5-(4-MePh)                                                                             2  Cl  Cl      Cl                                             1588     5-(4-MePh)                                                                             2  Cl  Cl      OMe                                            1589     5-(4-MePh)                                                                             2  Cl  Cl      SMe                                            1590     5-(4-MePh)                                                                             2  Cl  Cl      SO.sub.2 Me                                    1591     5-(4-MePh)                                                                             2  Cl  Me      Cl                                             1592     5-(4-MePh)                                                                             2  Cl  Me      SO.sub.2 Me                                    1593     5-(4-MePh)                                                                             2  Cl  OMe     Cl                                             1594     5-(4-MePh)                                                                             2  Cl  OMe     Br                                             1595     5-(4-MePh)                                                                             2  Cl  OMe     SO.sub.2 Me                                    1596     5-(4-MePh)                                                                             2  Cl  OEt     Br                                             1597     5-(4-MePh)                                                                             2  Br  H       OMe                                            1598     5-(4-MePh)                                                                             2  F   H       F                                              1599     5-(4-MePh)                                                                             2  I   I       I                                              1600     5-(4-MePh)                                                                             2  Me  H       CN                                             1601     5-(4-MePh)                                                                             2  Me  H       Me                                             1602     5-(4-MePh)                                                                             2  Me  H       OMe                                            1603     5-(4-MePh)                                                                             2  Me  Cl      Cl                                             1604     5-(4-MePh)                                                                             2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1605     5-(4-MePh)                                                                             2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1606     5-(4-MePh)                                                                             2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1607     5-(4-MePh)                                                                             2  NO.sub.2                                                                           H       Cl                                             1608     5-(4-MePh)                                                                             2  NO.sub.2                                                                           H       Br                                             1609     5-(4-MePh)                                                                             2  NO.sub.2                                                                           H       F                                              1610     5-(4-MePh)                                                                             2  NO.sub.2                                                                           H       CN                                             1611     5-(4-MePh)                                                                             2  NO.sub.2                                                                           H       SMe                                            1612     5-(4-MePh)                                                                             2  NO.sub.2                                                                           H       CF.sub.3                                       1613     5-(4-MePh)                                                                             2  NO.sub.2                                                                           OMe     Cl                                             1614     5-(4-MePh)                                                                             2  NO.sub.2                                                                           OMe     CF.sub.3                                       1615     5-(4-MePh)                                                                             2  CF.sub.3                                                                           H       Cl                                             1616     5-(4-MePh)                                                                             2  CF.sub.3                                                                           H       Br                                             1617     5-(4-MePh)                                                                             2  CF.sub.3                                                                           H       SMe                                            1618     5-(4-MePh)                                                                             2  CF.sub.3                                                                           H       CF.sub.3                                       1619     5-(4-MePh)                                                                             2  OMe H       Cl                                             1620     5-(4-MePh)                                                                             2  OMe H       OMe                                            __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________      ##STR17##                                                                     Compound No. of                       Characteristic                           the present invention                                                                     (R).sub.m                                                                            L  X   Y       Z     (Physical property)                      __________________________________________________________________________     1621       --    0  Cl  H       Cl                                             1622       --    0  Cl  H       SO.sub.2 Me                                    1623       --    0  Cl  H       NO.sub.2                                       1624       --    0  Cl  H       OMe                                            1625       --    0  Cl  H       Me                                             1626       --    0  Cl  H       Br                                             1627       --    0  Cl  H       F                                              1628       --    0  Cl  H       SMe                                            1629       --    0  Cl  H       S(O)Me                                         1630       --    0  Cl  H       CF.sub.3                                       1631       --    0  Cl  H       CN                                             1632       --    0  Cl  Cl      Cl                                             1633       --    0  Cl  Cl      OMe                                            1634       --    0  Cl  Cl      SMe                                            1635       --    0  Cl  Cl      SO.sub.2 Me                                    1636       --    0  Cl  Me      Cl                                             1637       --    0  Cl  Me      SO.sub.2 Me                                    1638       --    0  Cl  OMe     Cl                                             1639       --    0  Cl  OMe     Br                                             1640       --    0  Cl  OMe     SO.sub.2 Me                                    1641       --    0  Cl  OEt     Br                                             1642       --    0  Br  H       OMe                                            1643       --    0  F   H       F                                              1644       --    0  I   I       I                                              1645       --    0  Me  H       CN                                             1626       --    0  Me  H       Me                                             1627       --    0  Me  H       OMe                                            1628       --    0  Me  Cl      Cl                                             1629       --    0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1630       --    0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1631       --    0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1632       --    0  NO.sub.2                                                                           H       Cl                                             1633       --    0  NO.sub.2                                                                           H       Br                                             1634       --    0  NO.sub.2                                                                           H       F                                              1635       --    0  NO.sub.2                                                                           H       CN                                             1636       --    0  NO.sub.2                                                                           H       SMe                                            1637       --    0  NO.sub.2                                                                           H       CF.sub.3                                       1638       --    0  NO.sub.2                                                                           OMe     Cl                                             1639       --    0  NO.sub. 2                                                                          OMe     CF.sub.3                                       1640       --    0  CF.sub.3                                                                           H       Cl                                             1641       --    0  CF.sub.3                                                                           H       Br                                             1642       --    0  CF.sub.3                                                                           H       SMe                                            1643       --    0  CF.sub.3                                                                           H       CF.sub.3                                       1644       --    0  OMe H       Cl                                             1645       --    0  OMe H       OMe                                            1646       --    1  Cl  H       Cl                                             1647       --    1  Cl  H       SO.sub.2 Me                                    1648       --    1  Cl  H       NO.sub.2                                       1649       --    1  Cl  H       OMe                                            1650       --    1  Cl  H       Me                                             1651       --    1  Cl  H       Br                                             1652       --    1  Cl  H       F                                              1653       --    1  Cl  H       SMe                                            1654       --    1  Cl  H       S(O)Me                                         1655       --    1  Cl  H       CF.sub.3                                       1656       --    1  Cl  H       CN                                             1657       --    1  Cl  Cl      Cl                                             1658       --    1  Cl  Cl      OMe                                            1659       --    1  Cl  Cl      SMe                                            1660       --    1  Cl  Cl      SO.sub.2 Me                                    1661       --    1  Cl  Me      Cl                                             1662       --    1  Cl  Me      SO.sub.2 Me                                    1663       --    1  Cl  OMe     Cl                                             1664       --    1  Cl  OMe     Br                                             1665       --    1  Cl  OMe     SO.sub.2 Me                                    1666       --    1  Cl  Oet     Br                                             1667       --    1  Br  H       OMe                                            1668       --    1  F   H       F                                              1669       --    1  I   I       I                                              1670       --    1  Me  H       CN                                             1671       --    1  Me  H       Me                                             1672       --    1  Me  H       OMe                                            1673       --    1  Me  Cl      Cl                                             1674       --    1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1675       --    1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1676       --    1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1677       --    1  NO.sub.2                                                                           H       Cl                                             1678       --    1  NO.sub.2                                                                           H       Br                                             1679       --    1  NO.sub.2                                                                           H       F                                              1680       --    1  NO.sub.2                                                                           H       CN                                             1681       --    1  NO.sub.2                                                                           H       SMe                                            1682       --    1  NO.sub.2                                                                           H       CF.sub.3                                       1683       --    1  NO.sub.2                                                                           OMe     Cl                                             1684       --    1  NO.sub.2                                                                           OMe     CF.sub.3                                       1685       --    1  CF.sub.3                                                                           H       Cl                                             1686       --    1  CF.sub.3                                                                           H       Br                                             1687       --    1  CF.sub.3                                                                           H       SMe                                            1688       --    1  CF.sub.3                                                                           H       CF.sub.3                                       1689       --    1  OMe H       Cl                                             1690       --    1  OMe H       OMe                                            1691       --    2  Cl  H       Cl                                             1692       --    2  Cl  H       SO.sub.2 Me                                    1693       --    2  Cl  H       NO.sub.2                                       1694       --    2  Cl  H       OMe                                            1695       --    2  Cl  H       Me                                             1696       --    2  Cl  H       Br                                             1697       --    2  Cl  H       F                                              1698       --    2  Cl  H       SMe                                            1699       --    2  Cl  H       S(O)Me                                         1700       --    2  Cl  H       CF.sub.3                                       1701       --    2  Cl  H       CN                                             1702       --    2  Cl  Cl      Cl                                             1703       --    2  Cl  Cl      OMe                                            1704       --    2  Cl  Cl      SMe                                            1705       --    2  Cl  Cl      SO.sub.2 Me                                    1706       --    2  Cl  Me      Cl                                             1707       --    2  Cl  Me      SO.sub.2 Me                                    1708       --    2  Cl  OMe     Cl                                             1709       --    2  Cl  OMe     Br                                             1710       --    2  Cl  OMe     SO.sub.2 Me                                    1711       --    2  Cl  OEt     Br                                             1712       --    2  Br  H       OMe                                            1713       --    2  F   H       F                                              1714       --    2  I   I       I                                              1715       --    2  Me  H       CN                                             1716       --    2  Me  H       Me                                             1717       --    2  Me  H       OMe                                            1718       --    2  Me  Cl      Cl                                             1719       --    2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1720       --    2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1721       --    2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1722       --    2  NO.sub.2                                                                           H       Cl                                             1723       --    2  NO.sub.2                                                                           H       Br                                             1724       --    2  NO.sub.2                                                                           H       F                                              1725       --    2  NO.sub.2                                                                           H       CN                                             1726       --    2  NO.sub.2                                                                           H       SMe                                            1727       --    2  NO.sub.2                                                                           H       CF.sub.3                                       1728       --    2  NO.sub.2                                                                           OMe     Cl                                             1729       --    2  NO.sub.2                                                                           OMe     CF.sub.3                                       1730       --    2  CF.sub.3                                                                           H       Cl                                             1731       --    2  CF.sub.3                                                                           H       Br                                             1732       --    2  CF.sub.3                                                                           H       SMe                                            1733       --    2  CF.sub.3                                                                           H       CF.sub.3                                       1734       --    2  OMe H       Cl                                             1735       --    2  OMe H       OMe                                            1736       4-Me  0  Cl  H       Cl    Dark green crystal                                                             m.p. 55˜58° C.              1737       4-Me  0  Cl  H       SO.sub.2 Me                                    1738       4-Me  0  Cl  H       NO.sub.2                                       1739       4-Me  0  Cl  H       OMe                                            1740       4-Me  0  Cl  H       Me                                             1741       4-Me  0  Cl  H       Br                                             1742       4-Me  0  Cl  H       F                                              1743       4-Me  0  Cl  H       SMe                                            1744       4-Me  0  Cl  H       S(O)Me                                         1745       4-Me  0  Cl  H       CF.sub.3                                       1746       4-Me  0  Cl  H       CN                                             1747       4-Me  0  Cl  Cl      Cl                                             1748       4-Me  0  Cl  Cl      OMe                                            1749       4-Me  0  Cl  Cl      SMe                                            1750       4-Me  0  Cl  Cl      SO.sub.2 Me                                    1751       4-Me  0  Cl  Me      Cl                                             1752       4-Me  0  Cl  Me      SO.sub.2 Me                                    1753       4-Me  0  Cl  OMe     Cl                                             1754       4-Me  0  Cl  OMe     Br                                             1755       4-Me  0  Cl  OMe     SO.sub.2 Me                                    1756       4-Me  0  Cl  OEt     Br                                             1757       4-Me  0  Br  H       OMe                                            1758       4-Me  0  F   H       F                                              1759       4-Me  0  I   I       I                                              1760       4-Me  0  Me  H       CN                                             1761       4-Me  0  Me  H       Me                                             1762       4-Me  0  Me  H       OMe                                            1763       4-Me  0  Me  Cl      Cl                                             1764       4-Me  0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1765       4-Me  0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1766       4-Me  0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1767       4-Me  0  NO.sub.2                                                                           H       Cl                                             1768       4-Me  0  NO.sub.2                                                                           H       Br                                             1769       4-Me  0  NO.sub.2                                                                           H       F                                              1770       4-Me  0  NO.sub.2                                                                           H       CN                                             1771       4-Me  0  NO.sub.2                                                                           H       SMe                                            1772       4-Me  0  NO.sub.2                                                                           H       CF.sub.3                                       1773       4-Me  0  NO.sub.2                                                                           OMe     Cl                                             1774       4-Me  0  NO.sub.2                                                                           OMe     CF.sub.3                                       1775       4-Me  0  CF.sub.3                                                                           H       Cl                                             1776       4-Me  0  CF.sub.3                                                                           H       Br                                             1777       4-Me  0  CF.sub.3                                                                           H       SMe                                            1778       4-Me  0  CF.sub.3                                                                           H       CF.sub.3                                       1779       4-Me  0  OMe H       Cl                                             1780       4-Me  0  OMe H       OMe                                            1781       4-Me  1  Cl  H       Cl                                             1782       4-Me  1  Cl  H       SO.sub.2 Me                                    1783       4-Me  1  Cl  H       NO.sub.2                                       1784       4-Me  1  Cl  H       OMe                                            1785       4-Me  1  Cl  H       Me                                             1786       4-Me  1  Cl  H       Br                                             1787       4-Me  1  Cl  H       F                                              1788       4-Me  1  Cl  H       SMe                                            1789       4-Me  1  Cl  H       S(O)Me                                         1790       4-Me  1  Cl  H       CF.sub.3                                       1791       4-Me  1  Cl  H       CN                                             1792       4-Me  1  Cl  Cl      Cl                                             1793       4-Me  1  Cl  Cl      OMe                                            1794       4-Me  1  Cl  Cl      SMe                                            1795       4-Me  1  Cl  Cl      SO.sub.2 Me                                    1796       4-Me  1  Cl  Me      Cl                                             1797       4-Me  1  Cl  Me      SO.sub.2 Me                                    1798       4-Me  1  Cl  OMe     Cl                                             1799       4-Me  1  Cl  OMe     Br                                             1800       4-Me  1  Cl  OMe     SO.sub.2 Me                                    1801       4-Me  1  Cl  OEt     Br                                             1802       4-Me  1  Br  H       OMe                                            1803       4-Me  1  F   H       F                                              1804       4-Me  1  I   I       I                                              1805       4-Me  1  Me  H       CN                                             1806       4-Me  1  Me  H       Me                                             1807       4-Me  1  Me  H       OMe                                            1808       4-Me  1  Me  Cl      Cl                                             1809       4-Me  1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1810       4-Me  1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1811       4-Me  1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1812       4-Me  1  NO.sub.2                                                                           H       Cl                                             1813       4-Me  1  NO.sub.2                                                                           H       Br                                             1814       4-Me  1  NO.sub.2                                                                           H       F                                              1815       4-Me  1  NO.sub.2                                                                           H       CN                                             1816       4-Me  1  NO.sub.2                                                                           H       SMe                                            1817       4-Me  1  NO.sub.2                                                                           H       CF.sub.3                                       1818       4-Me  1  NO.sub.2                                                                           OMe     Cl                                             1819       4-Me  1  NO.sub.2                                                                           OMe     CF.sub.3                                       1820       4-Me  1  CF.sub.3                                                                           H       Cl                                             1821       4-Me  1  CF.sub.3                                                                           H       Br                                             1822       4-Me  1  CF.sub.3                                                                           H       SMe                                            1823       4-Me  1  CF.sub.3                                                                           H       CF.sub.3                                       1824       4-Me  1  OMe H       Cl                                             1825       4-Me  1  OMe H       OMe                                            1826       4-Me  2  Cl  H       Cl                                             1827       4-Me  2  Cl  H       SO.sub.2 Me                                    1828       4-Me  2  Cl  H       NO.sub.2                                       1829       4-Me  2  Cl  H       OMe                                            1830       4-Me  2  Cl  H       Me                                             1831       4-Me  2  Cl  H       Br                                             1832       4-Me  2  Cl  H       F                                              1833       4-Me  2  Cl  H       SMe                                            1834       4-Me  2  Cl  H       S(O)Me                                         1835       4-Me  2  Cl  H       CF.sub.3                                       1836       4-Me  2  Cl  H       CN                                             1837       4-Me  2  Cl  Cl      Cl                                             1838       4-Me  2  Cl  Cl      OMe                                            1839       4-Me  2  Cl  Cl      SMe                                            1840       4-Me  2  Cl  Cl      SO.sub.2 Me                                    1841       4-Me  2  Cl  Me      Cl                                             1842       4-Me  2  Cl  Me      SO.sub.2 Me                                    1843       4-Me  2  Cl  OMe     Cl                                             1844       4-Me  2  Cl  OMe     Br                                             1845       4-Me  2  Cl  OMe     SO.sub.2 Me                                    1846       4-Me  2  Cl  Oet     Br                                             1847       4-Me  2  Br  H       OMe                                            1848       4-Me  2  F   H       F                                              1849       4-Me  2  I   I       I                                              1850       4-Me  2  Me  H       CN                                             1851       4-Me  2  Me  H       Me                                             1852       4-Me  2  Me  H       OMe                                            1853       4-Me  2  Me  Cl      Cl                                             1854       4-Me  2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1855       4-Me  2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1856       4-Me  2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1857       4-Me  2  NO.sub.2                                                                           H       Cl                                             1858       4-Me  2  NO.sub.2                                                                           H       Br                                             1859       4-Me  2  NO.sub.2                                                                           H       F                                              1860       4-Me  2  NO.sub.2                                                                           H       CN                                             1861       4-Me  2  NO.sub.2                                                                           H       SMe                                            1862       4-Me  2  NO.sub.2                                                                           H       CF.sub.3                                       1863       4-Me  2  NO.sub.2                                                                           OMe     Cl                                             1864       4-Me  2  NO.sub.2                                                                           OMe     CF.sub.3                                       1865       4-Me  2  CF.sub.3                                                                           H       Cl                                             1866       4-Me  2  CF.sub.3                                                                           H       Br                                             1867       4-Me  2  CF.sub.3                                                                           H       Br                                             1868       4-Me  2  CF.sub.3                                                                           H       CF.sub.3                                       1869       4-Me  2  OMe H       Cl                                             1870       4-Me  2  OMe H       OMe                                            1871       5-Me  0  Cl  H       Cl                                             1872       5-Me  0  Cl  H       SO.sub.2 Me                                    1873       5-Me  0  Cl  H       NO.sub.2                                       1874       5-Me  0  Cl  H       OMe                                            1875       5-Me  0  Cl  H       Me                                             1876       5-Me  0  Cl  H       Br                                             1877       5-Me  0  Cl  H       F                                              1878       5-Me  0  Cl  H       SMe                                            1879       5-Me  0  Cl  H       S(O)Me                                         1880       5-Me  0  Cl  H       CF.sub.3                                       1881       5-Me  0  Cl  H       CN                                             1882       5-Me  0  Cl  Cl      Cl                                             1883       5-Me  0  Cl  Cl      OMe                                            1884       5-Me  0  Cl  Cl      SMe                                            1885       5-Me  0  Cl  Cl      SO.sub.2 Me                                    1886       5-Me  0  Cl  Me      Cl                                             1887       5-Me  0  Cl  Me      SO.sub.2 Me                                    1888       5-Me  0  Cl  OMe     Cl                                             1889       5-Me  0  Cl  OMe     Br                                             1890       5-Me  0  Cl  OMe     SO.sub.2 Me                                    1891       5-Me  0  Cl  OEt     Br                                             1892       5-Me  0  Br  H       OMe                                            1893       5-Me  0  F   H       F                                              1894       5-Me  0  I   I       I                                              1895       5-Me  0  Me  H       CN                                             1896       5-Me  0  Me  H       Me                                             1897       5-Me  0  Me  H       OMe                                            1898       5-Me  0  Me  Cl      Cl                                             1899       5-Me  0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1900       5-Me  0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1901       5-Me  0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1902       5-Me  0  NO.sub.2                                                                           H       Cl                                             1903       5-Me  0  NO.sub.2                                                                           H       Br                                             1904       5-Me  0  NO.sub.2                                                                           H       F                                              1905       5-Me  0  NO.sub.2                                                                           H       CN                                             1906       5-Me  0  NO.sub.2                                                                           H       SMe                                            1907       5-Me  0  NO.sub.2                                                                           H       CF.sub.3                                       1908       5-Me  0  NO.sub.2                                                                           OMe     Cl                                             1909       5-Me  0  NO.sub.2                                                                           OMe     CF.sub.3                                       1910       5-Me  0  CF.sub.3                                                                           H       Cl                                             1911       5-Me  0  CF.sub.3                                                                           H       Br                                             1912       5-Me  0  CF.sub.3                                                                           H       SMe                                            1913       5-Me  0  CF.sub.3                                                                           H       CF.sub.3                                       1914       5-Me  0  OMe H       Cl                                             1915       5-Me  0  OMe H       OMe                                            1916       5-Me  1  Cl  H       Cl                                             1917       5-Me  1  Cl  H       SO.sub.2 Me                                    1918       5-Me  1  Cl  H       NO.sub.2                                       1919       5-Me  1  Cl  H       OMe                                            1920       5-Me  1  Cl  H       Me                                             1921       5-Me  1  Cl  H       Br                                             1922       5-Me  1  Cl  H       F                                              1923       5-Me  1  Cl  H       SMe                                            1924       5-Me  1  Cl  H       S(O)Me                                         1925       5-Me  1  Cl  H       CF.sub.3                                       1926       5-Me  1  Cl  H       CN                                             1927       5-Me  1  Cl  Cl      Cl                                             1928       5-Me  1  Cl  Cl      OMe                                            1929       5-Me  1  Cl  Cl      SMe                                            1930       5-Me  1  Cl  Cl      SO.sub.2 Me                                    1931       5-Me  1  Cl  Me      Cl                                             1932       5-Me  1  Cl  Me      SO.sub.2 Me                                    1933       5-Me  1  Cl  OMe     Cl                                             1934       5-Me  1  Cl  OMe     Br                                             1935       5-Me  1  Cl  OMe     SO.sub.2 Me                                    1936       5-Me  1  Cl  OEt     Br                                             1937       5-Me  1  Br  H       OMe                                            1938       5-Me  1  F   H       F                                              1939       5-Me  1  I   I       I                                              1940       5-Me  1  Me  H       CN                                             1941       5-Me  1  Me  H       Me                                             1942       5-Me  1  Me  H       OMe                                            1943       5-Me  1  Me  Cl      Cl                                             1944       5-Me  1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1945       5-Me  1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1946       5-Me  1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1947       5-Me  1  NO.sub.2                                                                           H       Cl                                             1948       5-Me  1  NO.sub.2                                                                           H       Br                                             1949       5-Me  1  NO.sub.2                                                                           H       F                                              1950       5-Me  1  NO.sub.2                                                                           H       CN                                             1951       5-Me  1  NO.sub.2                                                                           H       SMe                                            1952       5-Me  1  NO.sub.2                                                                           H       CF.sub.3                                       1953       5-Me  1  NO.sub.2                                                                           OMe     Cl                                             1954       5-Me  1  NO.sub.2                                                                           OMe     CF.sub.3                                       1955       5-Me  1  CF.sub.3                                                                           H       Cl                                             1956       5-Me  1  CF.sub.3                                                                           H       Br                                             1957       5-Me  1  CF.sub.3                                                                           H       SMe                                            1958       5-Me  1  CF.sub.3                                                                           H       CF.sub.3                                       1959       5-Me  1  OMe H       Cl                                             1960       5-Me  1  OMe H       OMe                                            1961       5-Me  2  Cl  H       Cl                                             1962       5-Me  2  Cl  H       SO.sub.2 Me                                    1963       5-Me  2  Cl  H       NO.sub.2                                       1964       5-Me  2  Cl  H       OMe                                            1965       5-Me  2  Cl  H       Me                                             1966       5-Me  2  Cl  H       Br                                             1967       5-Me  2  Cl  H       F                                              1968       5-Me  2  Cl  H       SMe                                            1969       5-Me  2  Cl  H       S(O)Me                                         1970       5-Me  2  Cl  H       CF.sub.3                                       1971       5-Me  2  Cl  H       CN                                             1972       5-Me  2  Cl  Cl      Cl                                             1973       5-Me  2  Cl  Cl      OMe                                            1974       5-Me  2  Cl  Cl      SMe                                            1975       5-Me  2  Cl  Cl      SO.sub.2 Me                                    1976       5-Me  2  Cl  Me      Cl                                             1977       5-Me  2  Cl  Me      SO.sub.2 Me                                    1978       5-Me  2  Cl  OMe     Cl                                             1979       5-Me  2  Cl  OMe     Br                                             1980       5-Me  2  Cl  OMe     SO.sub.2 Me                                    1981       5-Me  2  Cl  OEt     Br                                             1982       5-Me  2  Br  H       OMe                                            1983       5-Me  2  F   H       F                                              1984       5-Me  2  I   I       I                                              1985       5-Me  2  Me  H       CN                                             1986       5-Me  2  Me  H       Me                                             1987       5-Me  2  Me  H       OMe                                            1988       5-Me  2  Me  Cl      Cl                                             1989       5-Me  2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    1990       5-Me  2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    1991       5-Me  2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    1992       5-Me  2  NO.sub.2                                                                           H       Cl                                             1993       5-Me  2  NO.sub.2                                                                           H       Br                                             1994       5-Me  2  NO.sub.2                                                                           H       F                                              1995       5-Me  2  NO.sub.2                                                                           H       CN                                             1996       5-Me  2  NO.sub.2                                                                           H       SMe                                            1997       5-Me  2  NO.sub.2                                                                           H       CF.sub.3                                       1998       5-Me  2  NO.sub.2                                                                           OMe     Cl                                             1999       5-Me  2  NO.sub.2                                                                           OMe     CF.sub.3                                       2000       5-Me  2  CF.sub.3                                                                           H       Cl                                             2001       5-Me  2  CF.sub.3                                                                           H       Br                                             2002       5-Me  2  CF.sub.3                                                                           H       SMe                                            2003       5-Me  2  CF.sub.3                                                                           H       CF.sub.3                                       2004       5-Me  2  OMe H       Cl                                             2005       5-Me  2  OMe H       OMe                                            2006       4.4-diMe                                                                             0  Cl  H       Cl                                             2007       4.4-diMe                                                                             0  Cl  H       SO.sub.2 Me                                    2008       4.4-diMe                                                                             0  Cl  H       NO.sub.2                                       2009       4.4-diMe                                                                             0  Cl  H       OMe                                            2010       4.4-diMe                                                                             0  Cl  H       Me                                             2011       4.4-diMe                                                                             0  Cl  H       Br                                             2012       2.4-diMe                                                                             0  Cl  H       F                                              2013       4.4-diMe                                                                             0  Cl  H       SMe                                            2014       4.4-diMe                                                                             0  Cl  H       S(O)Me                                         2015       4.4-diMe                                                                             0  Cl  H       CF.sub.3                                       2016       4.4-diMe                                                                             0  Cl  H       CN                                             2017       4.4-diMe                                                                             0  Cl  Cl      Cl                                             2018       4.4-diMe                                                                             0  Cl  Cl      OMe                                            2019       4.4-diMe                                                                             0  Cl  Cl      SMe                                            2020       4.4-diMe                                                                             0  Cl  Cl      SO.sub.2 Me                                    2021       4.4-diMe                                                                             0  Cl  Me      Cl                                             2022       4.4-diMe                                                                             0  Cl  Me      SO.sub.2 Me                                    2023       4.4-diMe                                                                             0  Cl  OMe     Cl                                             2024       4.4-diMe                                                                             0  Cl  OMe     Br                                             2025       4.4-diMe                                                                             0  Cl  OMe     SO.sub.2 Me                                    2026       4.4-diMe                                                                             0  Cl  OEt     Br                                             2027       4.4-diMe                                                                             0  Br  H       OMe                                            2028       4.4-diMe                                                                             0  F   H       F                                              2029       4.4-diMe                                                                             0  I   I       I                                              2030       4.4-diMe                                                                             0  Me  H       CN                                             2031       4.4-diMe                                                                             0  Me  H       Me                                             2032       4.4-diMe                                                                             0  Me  H       OMe                                            2033       4.4-diMe                                                                             0  Me  Cl      Cl                                             2034       4.4-diMe                                                                             0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2035       4.4-diMe                                                                             0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2036       4.4-diMe                                                                             0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2037       4.4-diMe                                                                             0  NO.sub.2                                                                           H       Cl                                             2038       4.4-diMe                                                                             0  NO.sub.2                                                                           H       Br                                             2039       4.4-diMe                                                                             0  NO.sub.2                                                                           H       F                                              2040       4.4-diMe                                                                             0  NO.sub.2                                                                           H       CN                                             2041       4.4-diMe                                                                             0  NO.sub.2                                                                           H       SMe                                            2042       4.4-diMe                                                                             0  NO.sub.2                                                                           H       CF.sub.3                                       2043       4.4-diMe                                                                             0  NO.sub.2                                                                           OMe     Cl                                             2044       4.4-diMe                                                                             0  NO.sub.2                                                                           OMe     CF.sub.3                                       2045       4.4-diMe                                                                             0  CF.sub.3                                                                           H       Cl                                             2046       4.4-diMe                                                                             0  CF.sub.3                                                                           H       Br                                             2047       4.4-diMe                                                                             0  CF.sub.3                                                                           H       SMe                                            2048       4.4-diMe                                                                             0  CF.sub.3                                                                           H       CF.sub.3                                       2049       4.4-diMe                                                                             0  OMe H       Cl                                             2050       4.4-diMe                                                                             0  OMe H       OMe                                            2051       4.4-diMe                                                                             1  Cl  H       Cl                                             2052       4.4-diMe                                                                             1  Cl  H       SO.sub.2 Me                                    2053       4.4-diMe                                                                             1  Cl  H       NO.sub.2                                       2054       4.4-diMe                                                                             1  Cl  H       OMe                                            2055       4.4-diMe                                                                             1  Cl  H       Me                                             2056       4.4-diMe                                                                             1  Cl  H       Br                                             2057       4.4-diMe                                                                             1  Cl  H       F                                              2058       4.4-diMe                                                                             1  Cl  H       SMe                                            2059       4.4-diMe                                                                             1  Cl  H       S(O)Me                                         2060       4.4-diMe                                                                             1  Cl  H       CF.sub.3                                       2061       4.4-diMe                                                                             1  Cl  H       CN                                             2062       4.4-diMe                                                                             1  Cl  Cl      Cl                                             2063       4.4-diMe                                                                             1  Cl  Cl      OMe                                            2064       4.4-diMe                                                                             1  Cl  Cl      SMe                                            2065       4.4-diMe                                                                             1  Cl  Cl      SO.sub.2 Me                                    2066       4.4-diMe                                                                             1  Cl  Me      Cl                                             2067       4.4-diMe                                                                             1  Cl  Me      SO.sub.2 Me                                    2068       4.4-diMe                                                                             1  Cl  OMe     Cl                                             2069       4.4-diMe                                                                             1  Cl  OMe     Br                                             2070       4.4-diMe                                                                             1  Cl  OMe     SO.sub.2 Me                                    2071       4.4-diMe                                                                             1  Cl  OEt     Br                                             2072       4.4-diMe                                                                             1  Br  H       OMe                                            2073       4.4-diMe                                                                             1  F   H       F                                              2074       4.4-diMe                                                                             1  I   I       I                                              2075       4.4-diMe                                                                             1  Me  H       CN                                             2076       4.4-diMe                                                                             1  Me  H       Me                                             2077       4.4-diMe                                                                             1  Me  H       OMe                                            2078       4.4-diMe                                                                             1  Me  Cl      Cl                                             2079       4.4-diMe                                                                             1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2080       4.4-diMe                                                                             1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2081       4.4-diMe                                                                             1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2082       4.4-diMe                                                                             1  NO.sub.2                                                                           H       Cl                                             2083       4.4-diMe                                                                             1  NO.sub.2                                                                           H       Br                                             2084       4.4-diMe                                                                             1  NO.sub.2                                                                           H       F                                              2085       4.4-diMe                                                                             1  NO.sub.2                                                                           H       CN                                             2086       4.4-diMe                                                                             1  NO.sub.2                                                                           H       SMe                                            2087       4.4-diMe                                                                             1  NO.sub.2                                                                           H       CF.sub.3                                       2088       4.4-diMe                                                                             1  NO.sub.2                                                                           OMe     Cl                                             2089       4.4-diMe                                                                             1  NO.sub.2                                                                           OMe     CF.sub.3                                       2090       4.4-diMe                                                                             1  CF.sub.3                                                                           H       Cl                                             2091       4.4-diMe                                                                             1  CF.sub.3                                                                           H       Br                                             2092       4.4-diMe                                                                             1  CF.sub.3                                                                           H       SMe                                            2093       4.4-diMe                                                                             1  CF.sub.3                                                                           H       CF.sub.3                                       2094       4.4-diMe                                                                             1  OMe H       Cl                                             2095       4.4-diMe                                                                             1  OMe H       OMe                                            2096       4.4-diMe                                                                             2  Cl  H       Cl                                             2097       4.4-diMe                                                                             2  Cl  H       SO.sub.2 Me                                    2098       4.4-diMe                                                                             2  Cl  H       NO.sub.2                                       2099       4.4-diMe                                                                             2  Cl  H       OMe                                            2100       4.4-diMe                                                                             2  Cl  H       Me                                             2101       4.4-diMe                                                                             2  Cl  H       Br                                             2102       4.4-diMe                                                                             2  Cl  H       F                                              2103       4.4-diMe                                                                             2  Cl  H       SMe                                            2104       4.4-diMe                                                                             2  Cl  H       S(O)Me                                         2105       4.4-diMe                                                                             2  Cl  H       CF.sub.3                                       2106       4.4-diMe                                                                             2  Cl  H       CN                                             2107       4.4-diMe                                                                             2  Cl  Cl      Cl                                             2108       4.4-diMe                                                                             2  Cl  Cl      OMe                                            2109       4.4-diMe                                                                             2  Cl  Cl      SMe                                            2110       4.4-diMe                                                                             2  Cl  Cl      SO.sub.2 Me                                    2111       4.4-diMe                                                                             2  Cl  Me      Cl                                             2112       4.4-diMe                                                                             2  Cl  Me      SO.sub.2 Me                                    2113       4.4-diMe                                                                             2  Cl  OMe     Cl                                             2114       4.4-diMe                                                                             2  Cl  OMe     Br                                             2115       4.4-diMe                                                                             2  Cl  OMe     SO.sub.2 Me                                    2116       4.4-diMe                                                                             2  Cl  OEt     Br                                             2117       4.4-diMe                                                                             2  Br  H       OMe                                            2118       4.4-diMe                                                                             2  F   H       F                                              2119       4.4-diMe                                                                             2  I   I       I                                              2120       4.4-diMe                                                                             2  Me  H       CN                                             2121       4.4-diMe                                                                             2  Me  H       Me                                             2122       4.4-diMe                                                                             2  Me  H       OMe                                            2123       4.4-diMe                                                                             2  Me  Cl      Cl                                             2124       4.4-diMe                                                                             2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2125       4.4-diMe                                                                             2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2126       4.4-diMe                                                                             2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2127       4.4-diMe                                                                             2  NO.sub.2                                                                           H       Cl                                             2128       4.4-diMe                                                                             2  NO.sub.2                                                                           H       Br                                             2129       4.4-diMe                                                                             2  NO.sub.2                                                                           H       F                                              2130       4.4-diMe                                                                             2  NO.sub.2                                                                           H       CN                                             2131       4.4-diMe                                                                             2  NO.sub.2                                                                           H       SMe                                            2132       4.4-diMe                                                                             2  NO.sub.2                                                                           H       CF.sub.3                                       2133       4.4-diMe                                                                             2  NO.sub.2                                                                           OMe     Cl                                             2134       4.4-diMe                                                                             2  NO.sub.2                                                                           OMe     CF.sub.3                                       2135       4.4-diMe                                                                             2  CF.sub.3                                                                           H       Cl                                             2136       4.4-diMe                                                                             2  CF.sub.3                                                                           H       Br                                             2137       4.4-diMe                                                                             2  CF.sub.3                                                                           H       SMe                                            2138       4.4-diMe                                                                             2  CF.sub.3                                                                           H       CF.sub.3                                       2139       4.4-diMe                                                                             2  OMe H       Cl                                             2140       4.4-diMe                                                                             2  OMe H       OMe                                            2141       5.5-diMe                                                                             0  Cl  H       Cl                                             2142       5.5-diMe                                                                             0  Cl  H       SO.sub.2 Me                                    2143       5.5-diMe                                                                             0  Cl  H       NO.sub.2                                       2144       5.5-diMe                                                                             0  Cl  H       OMe                                            2145       5.5-diMe                                                                             0  Cl  H       Me                                             2146       5.5-diMe                                                                             0  Cl  H       Br                                             2147       5.5-diMe                                                                             0  Cl  H       F                                              2148       5.5-diMe                                                                             0  Cl  H       SMe                                            2149       5.5-diMe                                                                             0  Cl  H       S(O)Me                                         2150       5.5-diMe                                                                             0  Cl  H       CF.sub.3                                       2151       5.5-diMe                                                                             0  Cl  H       CN                                             2152       5.5-diMe                                                                             0  Cl  Cl      Cl                                             2153       5.5-diMe                                                                             0  Cl  Cl      OMe                                            2154       5.5-diMe                                                                             0  Cl  Cl      SMe                                            2155       5.5-diMe                                                                             0  Cl  Cl      SO.sub.2 Me                                    2156       5.5-diMe                                                                             0  Cl  Me      Cl                                             2157       5.5-diMe                                                                             0  Cl  Me      SO.sub.2 Me                                    2158       5.5-diMe                                                                             0  Cl  OMe     Cl                                             2159       5.5-diMe                                                                             0  Cl  OMe     Br                                             2160       5.5-diMe                                                                             0  Cl  OMe     SO.sub.2 Me                                    2161       5.5-diMe                                                                             0  Cl  OEt     Br                                             2162       5.5-diMe                                                                             0  Br  H       OMe                                            2163       5.5-diMe                                                                             0  F   H       F                                              2164       5.5-diMe                                                                             0  I   I       I                                              2165       5.5-diMe                                                                             0  Me  H       CN                                             2166       5.5-diMe                                                                             0  Me  H       Me                                             2167       5.5-diMe                                                                             0  Me  H       OMe                                            2168       5.5-diMe                                                                             0  Me  Cl      Cl                                             2169       5.5-diMe                                                                             0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2170       5.5-diMe                                                                             0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2171       5.5-diMe                                                                             0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2172       5.5-diMe                                                                             0  NO.sub.2                                                                           H       Cl                                             2173       5.5-diMe                                                                             0  NO.sub.2                                                                           H       Br                                             2174       5.5-diMe                                                                             0  NO.sub.2                                                                           H       F                                              2175       5.5-diMe                                                                             0  NO.sub.2                                                                           H       CN                                             2176       5.5-diMe                                                                             0  NO.sub.2                                                                           H       SMe                                            2177       5.5-diMe                                                                             0  NO.sub.2                                                                           H       CF.sub.3                                       2178       5.5-diMe                                                                             0  NO.sub.2                                                                           OMe     Cl                                             2179       5.5-diMe                                                                             0  NO.sub.2                                                                           OMe     CF.sub.3                                       2180       5.5-diMe                                                                             0  CF.sub.3                                                                           H       Cl                                             2181       5.5-diMe                                                                             0  CF.sub.3                                                                           H       Br                                             2182       5.5-diMe                                                                             0  CF.sub.3                                                                           H       SMe                                            2183       5.5-diMe                                                                             0  CF.sub.3                                                                           H       CF.sub.3                                       2184       5.5-diMe                                                                             0  OMe H       Cl                                             2185       5.5-diMe                                                                             0  OMe H       OMe                                            2186       5.5-diMe                                                                             0  Cl  H       Cl                                             2187       5.5-diMe                                                                             0  Cl  H       SO.sub.2 Me                                    2188       5.5-diMe                                                                             0  Cl  H       NO.sub.2                                       2189       5.5-diMe                                                                             0  Cl  H       OMe                                            2190       5.5-diMe                                                                             0  Cl  H       Me                                             2191       5.5-diMe                                                                             1  Cl  H       Br                                             2192       5.5-diMe                                                                             1  Cl  H       F                                              2193       5.5-diMe                                                                             1  Cl  H       SMe                                            2194       5.5-diMe                                                                             1  Cl  H       S(O)Me                                         2195       5.5-diMe                                                                             1  Cl  H       CF.sub.3                                       2196       5.5-diMe                                                                             1  Cl  H       CN                                             2197       5.5-diMe                                                                             1  Cl  Cl      Cl                                             2198       5.5-diMe                                                                             1  Cl  Cl      OMe                                            2199       5.5-diMe                                                                             1  Cl  Cl      SMe                                            2200       5.5-diMe                                                                             1  Cl  Cl      SO.sub.2 Me                                    2201       5.5-diMe                                                                             1  Cl  Me      Cl                                             2202       5.5-diMe                                                                             1  Cl  Me      SO.sub.2 Me                                    2203       5.5-diMe                                                                             1  Cl  OMe     Cl                                             2204       5.5-diMe                                                                             1  Cl  OMe     Br                                             2205       5.5-diMe                                                                             1  Cl  OMe     SO.sub.2 Me                                    2206       5.5-diMe                                                                             1  Cl  OEt     Br                                             2207       5.5-diMe                                                                             1  Br  H       OMe                                            2208       5.5-diMe                                                                             1  F   H       F                                              2209       5.5-diMe                                                                             1  I   I       I                                              2210       5.5-diMe                                                                             1  Me  H       CN                                             2211       5.5-diMe                                                                             1  Me  H       Me                                             2212       5.5-diMe                                                                             1  Me  H       OMe                                            2213       5.5-diMe                                                                             1  Me  Cl      Cl                                             2214       5.5-diMe                                                                             1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2215       5.5-diMe                                                                             1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2216       5.5-diMe                                                                             1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2217       5.5-diMe                                                                             1  NO.sub.2                                                                           H       Cl                                             2218       5.5-diMe                                                                             1  NO.sub.2                                                                           H       Br                                             2219       5.5-diMe                                                                             1  NO.sub.2                                                                           H       F                                              2220       5.5-diMe                                                                             1  NO.sub.2                                                                           H       CN                                             2221       5.5-diMe                                                                             1  NO.sub.2                                                                           H       SMe                                            2222       5.5-diMe                                                                             1  NO.sub.2                                                                           H       CF.sub.3                                       2223       5.5-diMe                                                                             1  NO.sub.2                                                                           OMe     Cl                                             2224       5.5-diMe                                                                             1  NO.sub.2                                                                           OMe     CF.sub.3                                       2225       5.5-diMe                                                                             1  CF.sub.3                                                                           H       Cl                                             2226       5.5-diMe                                                                             1  CF.sub.3                                                                           H       Br                                             2227       5.5-diMe                                                                             1  CF.sub.3                                                                           H       SMe                                            2228       5.5-diMe                                                                             1  CF.sub.3                                                                           H       CF.sub.3                                       2229       5.5-diMe                                                                             1  OMe H       Cl                                             2230       5.5-diMe                                                                             1  OMe H       OMe                                            2231       5.5-diMe                                                                             2  Cl  H       Cl                                             2232       5.5-diMe                                                                             2  Cl  H       SO.sub.2 Me                                    2233       5.5-diMe                                                                             2  Cl  H       NO.sub.2                                       2234       5.5-diMe                                                                             2  Cl  H       OMe                                            2235       5.5-diMe                                                                             2  Cl  H       Me                                             2236       5.5-diMe                                                                             2  Cl  H       Br                                             2237       5.5-diMe                                                                             2  Cl  H       F                                              2238       5.5-diMe                                                                             2  Cl  H       SMe                                            2239       5.5-diMe                                                                             2  Cl  H       S(O)Me                                         2240       5.5-diMe                                                                             2  Cl  H       CF.sub.3                                       2241       5.5-diMe                                                                             2  Cl  H       CN                                             2242       5.5-diMe                                                                             2  Cl  Cl      Cl                                             2243       5.5-diMe                                                                             2  Cl  Cl      OMe                                            2244       5.5-diMe                                                                             2  Cl  Cl      SMe                                            2245       5.5-diMe                                                                             2  Cl  Cl      SO.sub.2 Me                                    2246       5.5-diMe                                                                             2  Cl  Me      Cl                                             2247       5.5-diMe                                                                             2  Cl  Me      SO.sub.2 Me                                    2248       5.5-diMe                                                                             2  Cl  OMe     Cl                                             2249       5.5-diMe                                                                             2  Cl  OMe     Br                                             2250       5.5-diMe                                                                             2  Cl  OMe     SO.sub.2 Me                                    2251       5.5-diMe                                                                             2  Cl  OEt     Br                                             2252       5.5-diMe                                                                             2  Br  H       OMe                                            2253       5.5-diMe                                                                             2  F   H       F                                              2254       5.5-diMe                                                                             2  I   I       I                                              2255       5.5-diMe                                                                             2  Me  H       CN                                             2256       5.5-diMe                                                                             2  Me  H       Me                                             2257       5.5-diMe                                                                             2  Me  H       OMe                                            2258       5.5-diMe                                                                             2  Me  Cl      Cl                                             2259       5.5-diMe                                                                             2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2260       5.5-diMe                                                                             2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2261       5.5-diMe                                                                             2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2262       5.5-diMe                                                                             2  NO.sub.2                                                                           H       Cl                                             2263       5.5-diMe                                                                             2  NO.sub.2                                                                           H       Br                                             2264       5.5-diMe                                                                             2  NO.sub.2                                                                           H       F                                              2265       5.5-diMe                                                                             2  NO.sub.2                                                                           H       CN                                             2266       5.5-diMe                                                                             2  NO.sub.2                                                                           H       SMe                                            2267       5.5-diMe                                                                             2  NO.sub.2                                                                           H       CF.sub.3                                       2268       5.5-diMe                                                                             2  NO.sub.2                                                                           OMe     Cl                                             2269       5.5-diMe                                                                             2  NO.sub.2                                                                           OMe     CF.sub.3                                       2270       5.5-diMe                                                                             2  CF.sub.3                                                                           H       Cl                                             2271       5.5-diMe                                                                             2  CF.sub.3                                                                           H       Br                                             2272       5.5-diMe                                                                             2  CF.sub.3                                                                           H       SMe                                            2273       5.5-diMe                                                                             2  CF.sub.3                                                                           H       CF.sub.3                                       2274       5.5-diMe                                                                             2  OMe H       Cl                                             2275       5.5-diMe                                                                             2  OMe H       OMe                                            2276       4.5-diMe                                                                             0  Cl  H       Cl                                             2277       4.5-diMe                                                                             0  Cl  H       SO.sub.2 Me                                    2278       4.5-diMe                                                                             0  Cl  H       NO.sub.2                                       2279       4.5-diMe                                                                             0  Cl  H       OMe                                            2280       4.5-diMe                                                                             0  Cl  H       Me                                             2281       4.5-diMe                                                                             0  Cl  H       Br                                             2282       4.5-diMe                                                                             0  Cl  H       F                                              2283       4.5-diMe                                                                             0  Cl  H       SMe                                            2284       4.5-diMe                                                                             0  Cl  H       S(O)Me                                         2285       4.5-diMe                                                                             0  Cl  H       CF.sub.3                                       2286       4.5-diMe                                                                             0  Cl  H       CN                                             2287       4.5-diMe                                                                             0  Cl  Cl      Cl                                             2288       4.5-diMe                                                                             0  Cl  Cl      OMe                                            2289       4.5-diMe                                                                             0  Cl  Cl      SMe                                            2290       4.5-diMe                                                                             0  Cl  Cl      SO.sub.2 Me                                    2291       4.5-diMe                                                                             0  Cl  Me      Cl                                             2292       4.5-diMe                                                                             0  Cl  Me      SO.sub.2 Me                                    2293       4.5-diMe                                                                             0  Cl  OMe     Cl                                             2294       4.5-diMe                                                                             0  Cl  OMe     Br                                             2295       4.5-diMe                                                                             0  Cl  OMe     SO.sub.2 Me                                    2296       4.5-diMe                                                                             0  Cl  OEt     Br                                             2297       4.5-diMe                                                                             0  Br  H       OMe                                            2298       4.5-diMe                                                                             0  F   H       F                                              2299       4.5-diMe                                                                             0  I   I       I                                              2300       4.5-diMe                                                                             0  Me  H       CN                                             2301       4.5-diMe                                                                             0  Me  H       Me                                             2302       4.5-diMe                                                                             0  Me  H       OMe                                            2303       4.5-diMe                                                                             0  Me  Cl      Cl                                             2304       4.5-diMe                                                                             0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2305       4.5-diMe                                                                             0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2306       4.5-diMe                                                                             0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2307       4.5-diMe                                                                             0  NO.sub.2                                                                           H       Cl                                             2308       4.5-diMe                                                                             0  NO.sub.2                                                                           H       Br                                             2309       4.5-diMe                                                                             0  NO.sub.2                                                                           H       F                                              2310       4.5-diMe                                                                             0  NO.sub.2                                                                           H       CN                                             2311       4.5-diMe                                                                             0  NO.sub.2                                                                           H       SMe                                            2312       4.5-diMe                                                                             0  NO.sub.2                                                                           H       CF.sub.3                                       2313       4.5-diMe                                                                             0  NO.sub.2                                                                           OMe     Cl                                             2314       4.5-diMe                                                                             0  NO.sub.2                                                                           OMe     CF.sub.3                                       2315       4.5-diMe                                                                             0  CF.sub.3                                                                           H       Cl                                             2316       4.5-diMe                                                                             0  CF.sub.3                                                                           H       Br                                             2317       4.5-diMe                                                                             0  CF.sub.3                                                                           H       SMe                                            2318       4.5-diMe                                                                             0  CF.sub.3                                                                           H       CF.sub.3                                       2319       4.5-diMe                                                                             0  OMe H       Cl                                             2320       4.5-diMe                                                                             0  OMe H       OMe                                            2321       4.5-diMe                                                                             1  Cl  H       Cl                                             2322       4.5-diMe                                                                             1  Cl  H       SO.sub.2 Me                                    2323       4.5-diMe                                                                             1  Cl  H       NO.sub.2                                       2324       4.5-diMe                                                                             1  Cl  H       OMe                                            2325       4.5-diMe                                                                             1  Cl  H       Me                                             2326       4.5-diMe                                                                             1  Cl  H       Br                                             2327       4.5-diMe                                                                             1  Cl  H       F                                              2328       4.5-diMe                                                                             1  Cl  H       SMe                                            2329       4.5-diMe                                                                             1  Cl  H       S(O)Me                                         2330       4.5-diMe                                                                             1  Cl  H       CF.sub.3                                       2331       4.5-diMe                                                                             1  Cl  H       CN                                             2332       4.5-diMe                                                                             1  Cl  Cl      Cl                                             2333       4.5-diMe                                                                             1  Cl  Cl      OMe                                            2334       4.5-diMe                                                                             1  Cl  Cl      SMe                                            2335       4.5-diMe                                                                             1  Cl  Cl      SO.sub.2 Me                                    2336       4.5-diMe                                                                             1  Cl  Me      Cl                                             2337       4.5-diMe                                                                             1  Cl  Me      SO.sub.2 Me                                    2338       4.5-diMe                                                                             1  Cl  OMe     Cl                                             2339       4.5-diMe                                                                             1  Cl  OMe     Br                                             2340       4.5-diMe                                                                             1  Cl  OMe     SO.sub.2 Me                                    2341       4.5-diMe                                                                             1  Cl  OEt     Br                                             2342       4.5-diMe                                                                             1  Br  H       OMe                                            2343       4.5-diMe                                                                             1  F   H       F                                              2344       4.5-diMe                                                                             1  I   I       I                                              2345       4.5-diMe                                                                             1  Me  H       CN                                             2346       4.5-diMe                                                                             1  Me  H       Me                                             2347       4.5-diMe                                                                             1  Me  H       OMe                                            2348       4.5-diMe                                                                             1  Me  Cl      Cl                                             2349       4.5-diMe                                                                             1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2350       4.5-diMe                                                                             1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2351       4.5-diMe                                                                             1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2352       4.5-diMe                                                                             1  NO.sub.2                                                                           H       Cl                                             2353       4.5-diMe                                                                             1  NO.sub.2                                                                           H       Br                                             2354       4.5-diMe                                                                             1  NO.sub.2                                                                           H       F                                              2355       4.5-diMe                                                                             1  NO.sub.2                                                                           H       CN                                             2356       4.5-diMe                                                                             1  NO.sub.2                                                                           H       SMe                                            2357       4.5-diMe                                                                             1  NO.sub.2                                                                           H       CF.sub.3                                       2358       4.5-diMe                                                                             1  NO.sub.2                                                                           OMe     Cl                                             2359       4.5-diMe                                                                             1  NO.sub.2                                                                           OMe     CF.sub.3                                       2360       4.5-diMe                                                                             1  CF.sub.3                                                                           H       Cl                                             2361       4.5-diMe                                                                             1  CF.sub.3                                                                           H       Br                                             2362       4.5-diMe                                                                             1  CF.sub.3                                                                           H       SMe                                            2363       4.5-diMe                                                                             1  CF.sub.3                                                                           H       CF.sub.3                                       2364       4.5-diMe                                                                             1  OMe H       Cl                                             2365       4.5-diMe                                                                             1  OMe H       OMe                                            2366       4.5-diMe                                                                             2  Cl  H       Cl                                             2367       4.5-diMe                                                                             2  Cl  H       SO.sub.2 Me                                    2368       4.5-diMe                                                                             2  Cl  H       NO.sub.2                                       2369       4.5-diMe                                                                             2  Cl  H       OMe                                            2370       4.5-diMe                                                                             2  Cl  H       Me                                             2371       4.5-diMe                                                                             2  Cl  H       Br                                             2372       4.5-diMe                                                                             2  Cl  H       F                                              2373       4.5-diMe                                                                             2  Cl  H       SMe                                            2374       4.5-diMe                                                                             2  Cl  H       S(O)Me                                         2375       4.5-diMe                                                                             2  Cl  H       CF.sub.3                                       2376       4.5-diMe                                                                             2  Cl  H       CN                                             2377       4.5-diMe                                                                             2  Cl  Cl      Cl                                             2378       4.5-diMe                                                                             2  Cl  Cl      OMe                                            2379       4.5-diMe                                                                             2  Cl  Cl      SMe                                            2380       4.5-diMe                                                                             2  Cl  Cl      SO.sub.2 Me                                    2381       4.5-diMe                                                                             2  Cl  Me      Cl                                             2382       4.5-diMe                                                                             2  Cl  Me      SO.sub.2 Me                                    2383       4.5-diMe                                                                             2  Cl  OMe     Cl                                             2384       4.5-diMe                                                                             2  Cl  OMe     Br                                             2385       4.5-diMe                                                                             2  Cl  OMe     SO.sub.2 Me                                    2386       4.5-diMe                                                                             2  Cl  OEt     Br                                             2387       4.5-diMe                                                                             2  Br  H       OMe                                            2388       4.5-diMe                                                                             2  F   H       F                                              2389       4.5-diMe                                                                             2  I   I       I                                              2390       4.5-diMe                                                                             2  Me  H       CN                                             2391       4.5-diMe                                                                             2  Me  H       Me                                             2392       4.5-diMe                                                                             2  Me  H       OMe                                            2393       4.5-diMe                                                                             2  Me  Cl      Cl                                             2394       4.5-diMe                                                                             2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2395       4.5-diMe                                                                             2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2396       4.5-diMe                                                                             2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2397       4.5-diMe                                                                             2  NO.sub.2                                                                           H       Cl                                             2398       4.5-diMe                                                                             2  NO.sub.2                                                                           H       Br                                             2399       4.5-diMe                                                                             2  NO.sub.2                                                                           H       F                                              2400       4.5-diMe                                                                             2  NO.sub.2                                                                           H       CN                                             2401       4.5-diMe                                                                             2  NO.sub.2                                                                           H       SMe                                            2402       4.5-diMe                                                                             2  NO.sub.2                                                                           H       CF.sub.3                                       2403       4.5-diMe                                                                             2  NO.sub.2                                                                           OMe     Cl                                             2404       4.5-diMe                                                                             2  NO.sub.2                                                                           OMe     CF.sub.3                                       2405       4.5-diMe                                                                             2  CF.sub.3                                                                           H       Cl                                             2406       4.5-diMe                                                                             2  CF.sub.3                                                                           H       Br                                             2407       4.5-diMe                                                                             2  CF.sub.3                                                                           H       SMe                                            2408       4.5-diMe                                                                             2  CF.sub.3                                                                           H       CF.sub.3                                       2409       4.5-diMe                                                                             2  OMe H       Cl                                             2410       4.5-diMe                                                                             2  OMe H       OMe                                            2411       4-Ph  0  Cl  H       Cl                                             2412       4-Ph  0  Cl  H       SO.sub.2 Me                                    2413       4-Ph  0  Cl  H       NO.sub.2                                       2414       4-Ph  0  Cl  H       OMe                                            2415       4-Ph  0  Cl  H       Me                                             2416       4-Ph  0  Cl  H       Br                                             2417       4-Ph  0  Cl  H       F                                              2418       4-Ph  0  Cl  H       SMe                                            2419       4-Ph  0  Cl  H       S(O)Me                                         2420       4-Ph  0  Cl  H       CF.sub.3                                       2421       4-Ph  0  Cl  H       CN                                             2422       4-Ph  0  Cl  Cl      Cl                                             2423       4-Ph  0  Cl  Cl      OMe                                            2424       4-Ph  0  Cl  Cl      SMe                                            2425       4-Ph  0  Cl  Cl      SO.sub.2 Me                                    2426       4-Ph  0  Cl  Me      Cl                                             2427       4-Ph  0  Cl  Me      SO.sub.2 Me                                    2428       4-Ph  0  Cl  OMe     Cl                                             2429       4-Ph  0  Cl  OMe     Br                                             2430       4-Ph  0  Cl  OMe     SO.sub.2 Me                                    2431       4-Ph  0  Cl  OEt     Br                                             2432       4-Ph  0  Br  H       OMe                                            2433       4-Ph  0  F   H       F                                              2434       4-Ph  0  I   I       I                                              2435       4-Ph  0  Me  H       CN                                             2436       4-Ph  0  Me  H       Me                                             2437       4-Ph  0  Me  H       OMe                                            2438       4-Ph  0  Me  Cl      Cl                                             2439       4-Ph  0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2440       4-Ph  0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2441       4-Ph  0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2442       4-Ph  0  NO.sub.2                                                                           H       Cl                                             2443       4-Ph  0  NO.sub.2                                                                           H       Br                                             2444       4-Ph  0  NO.sub.2                                                                           H       F                                              2445       4-Ph  0  NO.sub.2                                                                           H       CN                                             2446       4-Ph  0  NO.sub.2                                                                           H       SMe                                            2447       4-Ph  0  NO.sub.2                                                                           H       CF.sub.3                                       2448       4-Ph  0  NO.sub.2                                                                           OMe     Cl                                             2449       4-Ph  0  NO.sub. 2                                                                          OMe     CF.sub.3                                       2450       4-Ph  0  CF.sub.3                                                                           H       Cl                                             2451       4-Ph  0  CF.sub.3                                                                           H       Br                                             2452       4-Ph  0  CF.sub.3                                                                           H       SMe                                            2453       4-Ph  0  CF.sub.3                                                                           H       CF.sub.3                                       2454       4-Ph  0  OMe H       Cl                                             2455       4-Ph  0  OMe H       OMe                                            2456       4-Ph  1  Cl  H       Cl                                             2457       4-Ph  1  Cl  H       SO.sub.2 Me                                    2458       4-Ph  1  Cl  H       NO.sub.2                                       2459       4-Ph  1  Cl  H       OMe                                            2460       4-Ph  1  Cl  H       Me                                             2461       4-Ph  1  Cl  H       Br                                             2462       4-Ph  1  Cl  H       F                                              2463       4-Ph  1  Cl  H       SMe                                            2464       4-Ph  1  Cl  H       S(O)Me                                         2465       4-Ph  1  Cl  H       CF.sub.3                                       2466       4-Ph  1  Cl  H       CN                                             2467       4-Ph  1  Cl  Cl      Cl                                             2468       4-Ph  1  Cl  Cl      OMe                                            2469       4-Ph  1  Cl  Cl      SMe                                            2470       4-Ph  1  Cl  Cl      SO.sub.2 Me                                    2471       4-Ph  1  Cl  Me      Cl                                             2472       4-Ph  1  Cl  Me      SO.sub.2 Me                                    2473       4-Ph  1  Cl  OMe     Cl                                             2474       4-Ph  1  Cl  OMe     Br                                             2475       4-Ph  1  Cl  OMe     SO.sub.2 Me                                    2476       4-Ph  1  Cl  OEt     Br                                             2477       4-Ph  1  Br  H       OMe                                            2478       4-Ph  1  F   H       F                                              2479       4-Ph  1  I   I       I                                              2480       4-Ph  1  Me  H       CN                                             2481       4-Ph  1  Me  H       Me                                             2482       4-Ph  1  Me  H       OMe                                            2483       4-Ph  1  Me  Cl      Cl                                             2484       4-Ph  1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2485       4-Ph  1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2486       4-Ph  1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2487       4-Ph  1  NO.sub.2                                                                           H       Cl                                             2488       4-Ph  1  NO.sub.2                                                                           H       Br                                             2489       4-Ph  1  NO.sub.2                                                                           H       F                                              2490       4-Ph  1  NO.sub.2                                                                           H       CN                                             2491       4-Ph  1  NO.sub.2                                                                           H       SMe                                            2492       4-Ph  1  NO.sub.2                                                                           H       CF.sub.3                                       2493       4-Ph  1  NO.sub.2                                                                           OMe     Cl                                             2494       4-Ph  1  NO.sub.2                                                                           OMe     CF.sub.3                                       2495       4-Ph  1  CF.sub.3                                                                           H       Cl                                             2496       4-Ph  1  CF.sub.3                                                                           H       Br                                             2497       4-Ph  1  CF.sub.3                                                                           H       SMe                                            2498       4-Ph  1  CF.sub.3                                                                           H       CF.sub.3                                       2499       4-Ph  1  OMe H       Cl                                             2500       4-Ph  1  OMe H       OMe                                            2501       4-Ph  2  Cl  H       Cl                                             2502       4-Ph  2  Cl  H       SO.sub.2 Me                                    2503       4-Ph  2  Cl  H       NO.sub.2                                       2504       4-Ph  2  Cl  H       OMe                                            2505       4-Ph  2  Cl  H       Me                                             2506       4-Ph  2  Cl  H       Br                                             2507       4-Ph  2  Cl  H       F                                              2508       4-Ph  2  Cl  H       SMe                                            2509       4-Ph  2  Cl  H       S(O)Me                                         2510       4-Ph  2  Cl  H       CF.sub.3                                       2511       4-Ph  2  Cl  H       CN                                             2512       4-Ph  2  Cl  Cl      Cl                                             2513       4-Ph  2  Cl  Cl      OMe                                            2514       4-Ph  2  Cl  Cl      SMe                                            2515       4-Ph  2  Cl  Cl      SO.sub.2 Me                                    2516       4-Ph  2  Cl  Me      Cl                                             2517       4-Ph  2  Cl  Me      SO.sub.2 Me                                    2518       4-Ph  2  Cl  OMe     Cl                                             2519       4-Ph  2  Cl  OMe     Br                                             2520       4-Ph  2  Cl  OMe     SO.sub.2 Me                                    2521       4-Ph  2  Cl  OEt     Br                                             2522       4-Ph  2  Br  H       OMe                                            2523       4-Ph  2  F   H       F                                              2524       4-Ph  2  I   I       I                                              2525       4-Ph  2  Me  H       CN                                             2526       4-Ph  2  Me  H       Me                                             2527       4-Ph  2  Me  H       OMe                                            2528       4-Ph  2  Me  Cl      Cl                                             2529       4-Ph  2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2530       4-Ph  2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2531       4-Ph  2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2532       4-Ph  2  NO.sub.2                                                                           H       Cl                                             2533       4-Ph  2  NO.sub.2                                                                           H       Br                                             2534       4-Ph  2  NO.sub.2                                                                           H       F                                              2535       4-Ph  2  NO.sub.2                                                                           H       CN                                             2536       4-Ph  2  NO.sub.2                                                                           H       SMe                                            2537       4-Ph  2  NO.sub.2                                                                           H       CF.sub.3                                       2538       4-Ph  2  NO.sub.2                                                                           OMe     Cl                                             2539       4-Ph  2  NO.sub.2                                                                           OMe     CF.sub.3                                       2540       4-Ph  2  CF.sub.3                                                                           H       Cl                                             2541       4-Ph  2  CF.sub.3                                                                           H       Br                                             2542       4-Ph  2  CF.sub.3                                                                           H       SMe                                            2543       4-Ph  2  CF.sub.3                                                                           H       CF.sub.3                                       2544       4-Ph  2  OMe H       Cl                                             2545       4-Ph  2  OMe H       OMe                                            2546       5-Ph  0  Cl  H       Cl                                             2547       5-Ph  0  Cl  H       SO.sub.2 Me                                    2548       5-Ph  0  Cl  H       NO.sub.2                                       2549       5-Ph  0  Cl  H       OMe                                            2550       5-Ph  0  Cl  H       Me                                             2551       5-Ph  0  Cl  H       Br                                             2552       5-Ph  0  Cl  H       F                                              2553       5-Ph  0  Cl  H       SMe                                            2554       5-Ph  0  Cl  H       S(O)Me                                         2555       5-Ph  0  Cl  H       CF.sub.3                                       2556       5-Ph  0  Cl  H       CN                                             2557       5-Ph  0  Cl  Cl      Cl                                             2558       5-Ph  0  Cl  Cl      OMe                                            2559       5-Ph  0  Cl  Cl      SMe                                            2560       5-Ph  0  Cl  Cl      SO.sub.2 Me                                    2561       5-Ph  0  Cl  Me      Cl                                             2562       5-Ph  0  Cl  Me      SO.sub.2 Me                                    2563       5-Ph  0  Cl  OMe     Cl                                             2564       5-Ph  0  Cl  OMe     Br                                             2565       5-Ph  0  Cl  OMe     SO.sub.2 Me                                    2566       5-Ph  0  Cl  OEt     Br                                             2567       5-Ph  0  Br  H       OMe                                            2568       5-Ph  0  F   H       F                                              2569       5-Ph  0  I   I       I                                              2570       5-Ph  0  Me  H       CN                                             2571       5-Ph  0  Me  H       Me                                             2572       5-Ph  0  Me  H       OMe                                            2573       5-Ph  0  Me  Cl      Cl                                             2574       5-Ph  0  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2575       5-Ph  0  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2576       5-Ph  0  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2577       5-Ph  0  NO.sub.2                                                                           H       Cl                                             2578       5-Ph  0  NO.sub.2                                                                           H       Br                                             2579       5-Ph  0  NO.sub.2                                                                           H       F                                              2580       5-Ph  0  NO.sub.2                                                                           H       CN                                             2581       5-Ph  0  NO.sub.2                                                                           H       SMe                                            2582       5-Ph  0  NO.sub.2                                                                           H       CF.sub.3                                       2583       5-Ph  0  NO.sub.2                                                                           OMe     Cl                                             2584       5-Ph  0  NO.sub.2                                                                           OMe     CF.sub.3                                       2585       5-Ph  0  CF.sub.3                                                                           H       Cl                                             2586       5-Ph  0  CF.sub.3                                                                           H       Br                                             2587       5-Ph  0  CF.sub.3                                                                           H       SMe                                            2588       5-Ph  0  CF.sub.3                                                                           H       CF.sub.3                                       2589       5-Ph  0  OMe H       Cl                                             2590       5-Ph  0  OMe H       OMe                                            2591       5-Ph  1  Cl  H       Cl                                             2592       5-Ph  1  Cl  H       SO.sub.2 Me                                    2593       5-Ph  1  Cl  H       NO.sub.2                                       2594       5-Ph  1  Cl  H       OMe                                            2595       5-Ph  1  Cl  H       Me                                             2596       5-Ph  1  Cl  H       Br                                             2597       5-Ph  1  Cl  H       F                                              2598       5-Ph  1  Cl  H       SMe                                            2599       5-Ph  1  Cl  H       S(O)Me                                         2600       5-Ph  1  Cl  H       CF.sub.3                                       2601       5-Ph  1  Cl  H       CN                                             2602       5-Ph  1  Cl  Cl      Cl                                             2603       5-Ph  1  Cl  Cl      OMe                                            2604       5-Ph  1  Cl  Cl      SMe                                            2605       5-Ph  1  Cl  Cl      SO.sub.2 Me                                    2606       5-Ph  1  Cl  Me      Cl                                             2607       5-Ph  1  Cl  Me      SO.sub.2 Me                                    2608       5-Ph  1  Cl  OMe     Cl                                             2609       5-Ph  1  Cl  OMe     Br                                             2610       5-Ph  1  Cl  OMe     SO.sub.2 Me                                    2611       5-Ph  1  Cl  OEt     Br                                             2612       5-Ph  1  Br  H       OMe                                            2613       5-Ph  1  F   H       F                                              2614       5-Ph  1  I   I       I                                              2615       5-Ph  1  Me  H       CN                                             2616       5-Ph  1  Me  H       Me                                             2617       5-Ph  1  Me  H       OMe                                            2618       5-Ph  1  Me  Cl      Cl                                             2619       5-Ph  1  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2620       5-Ph  1  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2621       5-Ph  1  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2622       5-Ph  1  NO.sub.2                                                                           H       Cl                                             2623       5-Ph  1  NO.sub.2                                                                           H       Br                                             2624       5-Ph  1  NO.sub.2                                                                           H       F                                              2625       5-Ph  1  NO.sub.2                                                                           H       CN                                             2626       5-Ph  1  NO.sub. 2                                                                          H       SMe                                            2627       5-Ph  1  NO.sub.2                                                                           H       CF.sub.3                                       2628       5-Ph  1  NO.sub.2                                                                           OMe     Cl                                             2629       5-Ph  1  NO.sub.2                                                                           OMe     CF.sub.3                                       2630       5-Ph  1  CF.sub.3                                                                           H       Cl                                             2631       5-Ph  1  CF.sub.3                                                                           H       Br                                             2632       5-Ph  1  CF.sub.3                                                                           H       SMe                                            2633       5-Ph  1  CF.sub.3                                                                           H       CF.sub.3                                       2634       5-Ph  1  OMe H       Cl                                             2635       5-Ph  1  OMe H       OMe                                            2636       5-Ph  2  Cl  H       Cl                                             2637       5-Ph  2  Cl  H       SO.sub.2 Me                                    2638       5-Ph  2  Cl  H       NO.sub.2                                       2639       5-Ph  2  Cl  H       OMe                                            2640       5-Ph  2  Cl  H       Me                                             2641       5-Ph  2  Cl  H       Br                                             2642       5-Ph  2  Cl  H       F                                              2643       5-Ph  2  Cl  H       SMe                                            2644       5-Ph  2  Cl  H       S(O)Me                                         2645       5-Ph  2  Cl  H       CF.sub.3                                       2646       5-Ph  2  Cl  H       CN                                             2647       5-Ph  2  Cl  Cl      Cl                                             2648       5-Ph  2  Cl  Cl      OMe                                            2649       5-Ph  2  Cl  Cl      SMe                                            2650       5-Ph  2  Cl  Cl      SO.sub.2 Me                                    2651       5-Ph  2  Cl  Me      Cl                                             2652       5-Ph  2  Cl  Me      SO.sub.2 Me                                    2653       5-Ph  2  Cl  OMe     Cl                                             2654       5-Ph  2  Cl  OMe     Br                                             2655       5-Ph  2  Cl  OMe     SO.sub.2 Me                                    2656       5-Ph  2  Cl  OEt     Br                                             2657       5-Ph  2  Br  H       OMe                                            2658       5-Ph  2  F   H       F                                              2659       5-Ph  2  I   I       I                                              2660       5-Ph  2  Me  H       CN                                             2661       5-Ph  2  Me  H       Me                                             2662       5-Ph  2  Me  H       OMe                                            2663       5-Ph  2  Me  Cl      Cl                                             2664       5-Ph  2  Me  CO.sub.2 Me                                                                            SO.sub.2 Me                                    2665       5-Ph  2  Me  CH.sub.2 OMe                                                                           SO.sub.2 Me                                    2666       5-Ph  2  Me  CH(Me)OMe                                                                              SO.sub.2 Me                                    2667       5-Ph  2  NO.sub.2                                                                           H       Cl                                             2668       5-Ph  2  NO.sub.2                                                                           H       Br                                             2669       5-Ph  2  NO.sub.2                                                                           H       F                                              2670       5-Ph  2  NO.sub.2                                                                           H       CN                                             2671       5-Ph  2  NO.sub.2                                                                           H       SMe                                            2672       5-Ph  2  NO.sub.2                                                                           H       CF.sub.3                                       2673       5-Ph  2  NO.sub.2                                                                           OMe     Cl                                             2674       5-Ph  2  NO.sub.2                                                                           OMe     CF.sub.3                                       2675       5-Ph  2  CF.sub.3                                                                           H       Cl                                             2676       5-Ph  2  CF.sub.3                                                                           H       Br                                             2677       5-Ph  2  CF.sub.3                                                                           H       SMe                                            2678       5-Ph  2  CF.sub.3                                                                           H       CF.sub.3                                       2679       5-Ph  2  OMe H       Cl                                             2680       5-Ph  2  OMe H       OMe                                            __________________________________________________________________________

                  TABLE 3                                                          ______________________________________                                         Com-                                                                           pound                                                                          No. of                                                                         the    Dose                                                                    present                                                                               (kg/                                                                    invention                                                                             ha)    EC     DI  CY   SO   GA   RO   ZE   TR                           ______________________________________                                          1     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                             7     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            16     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            17     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            29     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            30     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            32     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            37     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            1736   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            ______________________________________                                    

                  TABLE 4                                                          ______________________________________                                         Com-                                                                           pound                                                                          No. of                                                                         the    Dose                                                                    present                                                                               (kg/                                                                    invention                                                                             ha)    EC     DI  CY   SO   GA   RO   ZE   TR                           ______________________________________                                          1     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                             7     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            16     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            17     0.5    5      5   5    5    5    5    0    0                                   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            30     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            32     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            37     1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            1736   1.0    5      5   5    5    5    5    0    0                                   2.0    5      5   5    5    5    5    0    0                            ______________________________________                                     

What is claimed is:
 1. A herbicidal composition, comprising:a) a herbicidally effective amount of one or more benzoyl derivatives of the formula (I): ##STR18## wherein R is a lower alkyl group, or a phenyl group which is unsubstituted or substituted by a lower alkyl group, halogen atom or a lower alkoxy group;n is an integer of 3; m is an integer of from 0 to 6, and when m is an integer of from 2 to 6, the plurality of R is the same or different from one another; 1is an integer of 0, 1 or 2; X is a halogen atom, a nitro group, a cyano group, a lower alkyl group, a lower alkoxy group, or a lower haloalkyl group; Y is a hydrogen atom, halogen atom, a nitro group, a lower alkyl group which is unsubstituted or substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, or a lower alkoxycarbonyl group; and Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group, a lower haloalkylthio group, a lower alkylsulfinyl group, a lower haloalkylsulfinyl group, a lower alkylsulfonyl group or a lower haloalkylsulfonyl group; and b) an agriculturally acceptable carrier.
 2. The herbicidal composition of claim 1, wherein in the formula (I), Z is a halogen atom, a nitro group, a cyano group, a trifluoromethyl group, a lower alkoxy group, a lower alkylthio group or a lower alkylsulfonyl group.
 3. The herbicidal composition of claim 1, wherein in the formula (I) m is an integer of 0 or 1; is an integer of 0 or 1; and Z is a halogen atom, nitro group, cyano group, trifluoromethyl group, lower alkoxy group, lower alkylthio group or a lower alkylsulfonyl group.
 4. A herbicidal composition, comprising:a) a herbicidally effective amount of one or more benzoyl derivatives of the formula: ##STR19## wherein R is a hydrogen atom or a lower alkyl group;l is an integer of 0 or 1; X is a halogen atom or a nitro group; Y is a hydrogen atom or a lower alkyl group; and Z is a halogen atom or a trifluoromethyl group; and b) an agriculturally acceptable carrier.
 5. A method of controlling weeds, which comprises applying a herbicidally effective amount of the composition of claim 1 to a locus to be protected.
 6. A method of controlling weeds, which comprises applying a herbicidally effective amount of the composition of claim 4 to a locus to be protected. 